4,178
Views
56
CrossRef citations to date
0
Altmetric
Reviews

Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy

, &
Pages 3354-3368 | Received 26 May 2014, Accepted 08 Aug 2014, Published online: 01 Nov 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Shuichi Ota, Mamiko Miyashita, Yuka Yamagishi & Masahiro Ogasawara. (2021) Baseline immunity predicts prognosis of pancreatic cancer patients treated with WT1 and/or MUC1 peptide-loaded dendritic cell vaccination and a standard chemotherapy. Human Vaccines & Immunotherapeutics 17:12, pages 5563-5572.
Read now
Shuichi Hanada, Tomoko Tsuruta, Kouichi Haraguchi, Masato Okamoto, Haruo Sugiyama & Shigeo Koido. (2019) Long-term survival of pancreatic cancer patients treated with multimodal therapy combined with WT1-targeted dendritic cell vaccines. Human Vaccines & Immunotherapeutics 15:2, pages 397-406.
Read now
Li Xiao, Ulrike Erb, Kun Zhao, Thilo Hackert & Margot Zöller. (2017) Efficacy of vaccination with tumor-exosome loaded dendritic cells combined with cytotoxic drug treatment in pancreatic cancer. OncoImmunology 6:6.
Read now

Articles from other publishers (53)

Mahip Grewal, Taha Ahmed & Ammar Asrar Javed. (2023) Current state of radiomics in hepatobiliary and pancreatic malignancies. Artificial Intelligence Surgery 3:4, pages 217-32.
Crossref
Ana Bogut, Bojan Stojanovic, Marina Jovanovic, Milica Dimitrijevic Stojanovic, Nevena Gajovic, Bojana S. Stojanovic, Goran Balovic, Milan Jovanovic, Aleksandar Lazovic, Milos Mirovic, Milena Jurisevic, Ivan Jovanovic & Violeta Mladenovic. (2023) Galectin-1 in Pancreatic Ductal Adenocarcinoma: Bridging Tumor Biology, Immune Evasion, and Therapeutic Opportunities. International Journal of Molecular Sciences 24:21, pages 15500.
Crossref
Arenida Bartkeviciene, Aldona Jasukaitiene, Inga Zievyte, Darius Stukas, Sandra Ivanauskiene, Daiva Urboniene, Toivo Maimets, Kristaps Jaudzems, Astra Vitkauskiene, Jason Matthews, Zilvinas Dambrauskas & Antanas Gulbinas. (2023) Association between AHR Expression and Immune Dysregulation in Pancreatic Ductal Adenocarcinoma: Insights from Comprehensive Immune Profiling of Peripheral Blood Mononuclear Cells. Cancers 15:18, pages 4639.
Crossref
Deniz Tazeoglu, Sami Benli, Tahsin Colak & Feramuz Demir Apaydin. (2023) Comparative analysis of the sarcopenia and HALP score on postoperative outcomes in pancreatic cancer patients after pancreatoduodenectomy. Pancreatology 23:5, pages 530-536.
Crossref
Ammar A. Javed, Anne Floortje van Oosten, Joseph R. Habib, Alina Hasanain, Benedict Kinny-Köster, Georgios Gemenetzis, Vincent P. Groot, Ding Ding, John L. Cameron, Kelly J. Lafaro, William R. Burns, Richard A. Burkhart, Jun Yu, Jin He & Christopher L. Wolfgang. (2023) A Delay in Adjuvant Therapy Is Associated With Worse Prognosis Only in Patients With Transitional Circulating Tumor Cells After Resection of Pancreatic Ductal Adenocarcinoma. Annals of Surgery 277:6, pages 866-872.
Crossref
Gurbani Jolly, Tetyana Duka, Narayan Shivapurkar, Wenqiang Chen, Sunil Bansal, Amrita Cheema & Jill P. Smith. (2023) Cholecystokinin Receptor Antagonist Induces Pancreatic Stellate Cell Plasticity Rendering the Tumor Microenvironment Less Oncogenic. Cancers 15:10, pages 2811.
Crossref
Shi-Wei Guan, Quan Lin & Hai-Bo Yu. (2023) Intratumour microbiome of pancreatic cancer. World Journal of Gastrointestinal Oncology 15:5, pages 713-730.
Crossref
Chen Kai Huang, Lei Lv, Huanliang Chen, Ying Sun & Yong Ping. (2023) ENO1 promotes immunosuppression and tumor growth in pancreatic cancer. Clinical and Translational Oncology 25:7, pages 2250-2264.
Crossref
Lorraine QuillienLouis BuscailPierre Cordelier. (2023) Pancreatic Cancer Cell and Gene Biotherapies: Past, Present, and Future. Human Gene Therapy 34:3-4, pages 150-161.
Crossref
Ahmad Ali, Ugo Chianese, Chiara Papulino, Antonella Toraldo, Mawada Elmagboul Abdalla Abakar, Eugenia Passaro, Rosario Cennamo, Nunzio Del Gaudio, Lucia Altucci & Rosaria Benedetti. (2022) Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma. Cancers 14:15, pages 3799.
Crossref
Chao Dang, Min Wang, Tingting Qin & Renyi Qin. (2022) How can we better predict the prognosis of patients with pancreatic cancer undergoing surgery using an immune-nutritional scoring system?. Surgery 172:1, pages 291-302.
Crossref
Haotian Fu, Hongwei Sun, Hongru Kong, Bin Lou, Hao Chen, Yilin Zhou, Chaohao Huang, Lei Qin, Yunfeng Shan & Shengjie Dai. (2022) Discoveries in Pancreatic Physiology and Disease Biology Using Single-Cell RNA Sequencing. Frontiers in Cell and Developmental Biology 9.
Crossref
Liguo Ye, Long Wang, Ji’an Yang, Ping Hu, Chunyu Zhang, Shi’ao Tong, Zhennan Liu & Daofeng Tian. (2021) Identification of tumor antigens and immune subtypes in lower grade gliomas for mRNA vaccine development. Journal of Translational Medicine 19:1.
Crossref
Emma L. Newport, Ana Rita Pedrosa, Alexandra Njegic, Kairbaan M. Hodivala-Dilke & José M. Muñoz-Félix. (2021) Improved Immunotherapy Efficacy by Vascular Modulation. Cancers 13:20, pages 5207.
Crossref
Leonel Pekarek, Oscar Fraile‑Μartinez, Cielo Garcia‑Montero, Miguel Alvarez‑Mon, Julio Acero, Lidia Ruiz‑Llorente, Natalio García‑Honduvilla, Agustin Albillos, Julia Buján, Melchor Alvarez‑Mon, Luis Guijarro & Miguel Ortega. (2021) Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncology Letters 22:5.
Crossref
Rami Alzhrani, Hashem O. Alsaab, Kushal Vanamala, Ketki Bhise, Katyayani Tatiparti, Ayatakshi Barari, Samaresh Sau & Arun K. Iyer. (2021) Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes. Advanced Therapeutics 4:6, pages 2000262.
Crossref
Jai Hoon Yoon, Ye-Ji Jung & Sung-Hoon Moon. (2021) Immunotherapy for pancreatic cancer. World Journal of Clinical Cases 9:13, pages 2969-2982.
Crossref
Aaron J. Grossberg, Linda C. Chu, Christopher R. Deig, Eliot K. Fishman, William L. Hwang, Anirban Maitra, Daniel L. Marks, Arnav Mehta, Nima Nabavizadeh, Diane M. Simeone, Colin D. Weekes & Charles R. ThomasJrJr. (2020) Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma. CA: A Cancer Journal for Clinicians 70:5, pages 375-403.
Crossref
Tao Shen, Shengnan Jia, Guoping Ding, Dongnan Ping, Liangjing Zhou, Senhao Zhou & Liping Cao. (2020) BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations. iScience 23:8, pages 101431.
Crossref
Yukinari KatoTomokazu OhishiMasato SanoTeizo AsanoYusuke SayamaJunko TakeiManabu KawadaMika K. Kaneko. (2020) H 2 Mab-19 Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody Therapy Exerts Antitumor Activity in Pancreatic Cancer Xenograft Models . Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 39:3, pages 61-65.
Crossref
Kang Hyun Kim, Ho Kyoung Hwang, In Cheon Kang, Woo Jung Lee & Chang Moo Kang. (2020) Oncologic impact of preoperative prognostic nutritional index change in resected pancreatic cancer following neoadjuvant chemotherapy. Pancreatology 20:2, pages 247-253.
Crossref
Carole Siret, Aurélie Collignon, Françoise Silvy, Stéphane Robert, Thierry Cheyrol, Perrine André, Véronique Rigot, Juan Iovanna, Serge van de Pavert, Dominique Lombardo, Eric Mas & Anna Martirosyan. (2020) Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma. Frontiers in Immunology 10.
Crossref
Pei-wen Li, Shi Luo, Lin-yu Xiao, Bo-le Tian, Li Wang, Zhi-rong Zhang & Ying-chun Zeng. (2019) A novel gemcitabine derivative-loaded liposome with great pancreas-targeting ability. Acta Pharmacologica Sinica 40:11, pages 1448-1456.
Crossref
Michal Bassani-Sternberg, Antonia Digklia, Florian Huber, Dorothea Wagner, Christine Sempoux, Brian J. Stevenson, Anne-Christine Thierry, Justine Michaux, HuiSong Pak, Julien Racle, Caroline Boudousquie, Klara Balint, George Coukos, David Gfeller, Silvia Martin Lluesma, Alexandre Harari, Nicolas Demartines & Lana E. Kandalaft. (2019) A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma—A Proof of Antigen Discovery Feasibility in Three Patients. Frontiers in Immunology 10.
Crossref
Antonella Argentiero, Simona De Summa, Roberta Di Fonte, Rosa Maria Iacobazzi, Letizia Porcelli, Matteo Da Vià, Oronzo Brunetti, Amalia Azzariti, Nicola Silvestris & Antonio Giovanni Solimando. (2019) Gene Expression Comparison between the Lymph Node-Positive and -Negative Reveals a Peculiar Immune Microenvironment Signature and a Theranostic Role for WNT Targeting in Pancreatic Ductal Adenocarcinoma: A Pilot Study. Cancers 11:7, pages 942.
Crossref
Matteo Ligorio, Srinjoy Sil, Jose Malagon-Lopez, Linda T. Nieman, Sandra Misale, Mauro Di Pilato, Richard Y. Ebright, Murat N. Karabacak, Anupriya S. Kulkarni, Ann Liu, Nicole Vincent Jordan, Joseph W. Franses, Julia Philipp, Johannes Kreuzer, Niyati Desai, Kshitij S. Arora, Mihir Rajurkar, Elad Horwitz, Azfar Neyaz, Eric Tai, Neelima K.C. Magnus, Kevin D. Vo, Chittampalli N. Yashaswini, Francesco Marangoni, Myriam Boukhali, Jackson P. Fatherree, Leah J. Damon, Kristina Xega, Rushil Desai, Melissa Choz, Francesca Bersani, Adam Langenbucher, Vishal Thapar, Robert Morris, Ulrich F. Wellner, Oliver Schilling, Michael S. Lawrence, Andrew S. Liss, Miguel N. Rivera, Vikram Deshpande, Cyril H. Benes, Shyamala Maheswaran, Daniel A. Haber, Carlos Fernandez-Del-Castillo, Cristina R. Ferrone, Wilhelm Haas, Martin J. Aryee & David T. Ting. (2019) Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell 178:1, pages 160-175.e27.
Crossref
Didier Dréau, Laura Jeffords Moore, Mike Wu, Lopa Das Roy, Lloye Dillion, Travis Porter, Rahul Puri, Noor Momin, K. Dane Wittrup & Pinku Mukherjee. (2019) Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 9.
Crossref
Elaine Tan & Bassel El-Rayes. (2018) Pancreatic Cancer and Immunotherapy: Resistance Mechanisms and Proposed Solutions. Journal of Gastrointestinal Cancer 50:1, pages 1-8.
Crossref
Alicia A. Manning, Lei Zhao, Ziwen Zhu, Huaping Xiao, Chase G. Redington, Vivi A. Ding, Theodore Stewart-Hester, Qian Bai, Jacob Dunlap, Mark R. Wakefield & Yujiang Fang. (2018) IL-39 acts as a friend to pancreatic cancer. Medical Oncology 36:1.
Crossref
Deepak KGK & Rama Rao Malla. 2019. Exploring Pancreatic Metabolism and Malignancy. Exploring Pancreatic Metabolism and Malignancy 237 251 .
Limei Shen, Jingjing Li, Qi Liu, Wantong Song, Xueqiong Zhang, Karthik Tiruthani, Haiyang Hu, Manisit Das, Tyler Jay Goodwin, Rihe Liu & Leaf Huang. (2018) Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers. ACS Nano 12:10, pages 9830-9841.
Crossref
Jian-wei Xu, Lei Wang, Yu-gang Cheng, Guang-yong Zhang, San-yuan Hu, Bin Zhou & Han-xiang Zhan. (2018) Immunotherapy for pancreatic cancer: A long and hopeful journey. Cancer Letters 425, pages 143-151.
Crossref
Federico Nichetti, Antonio Marra, Francesca Corti, Alessandro Guidi, Alessandra Raimondi, Natalie Prinzi, Filippo de Braud & Sara Pusceddu. (2018) The Role of Mesothelin as a Diagnostic and Therapeutic Target in Pancreatic Ductal Adenocarcinoma: A Comprehensive Review. Targeted Oncology 13:3, pages 333-351.
Crossref
Flavia Fontana, Patrícia Figueiredo, Tomás Bauleth-Ramos, Alexandra Correia & Hélder A. Santos. (2018) Immunostimulation and Immunosuppression: Nanotechnology on the Brink. Small Methods 2:5, pages 1700347.
Crossref
Jill P. Smith, Shangzi Wang, Sandeep Nadella, Sandra A. Jablonski & Louis M. Weiner. (2017) Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice. Cancer Immunology, Immunotherapy 67:2, pages 195-207.
Crossref
Sergio Alfieri, Fausto Rosa, Dario Di Miceli & Giovanni Battista Doglietto. 2018. Surgical Management of Elderly Patients. Surgical Management of Elderly Patients 347 363 .
Yuanqing Yan, Ruli Gao, Thao L.P. Trinh & Maria B. Grant. (2017) Immunodeficiency in Pancreatic Adenocarcinoma with Diabetes Revealed by Comparative Genomics. Clinical Cancer Research 23:20, pages 6363-6373.
Crossref
Peng Xue, Junjie Hang, Weiyi Huang, Shaobo Li, Ning Li, Yuzo Kodama, Shigemi Matsumoto, Kyoichi Takaori, Lifei Zhu & Masashi Kanai. (2017) Validation of Lymphocyte-to-Monocyte Ratio as a Prognostic Factor in Advanced Pancreatic Cancer. Pancreas 46:8, pages 1011-1017.
Crossref
Jonas R.M. Van Audenaerde, Jorrit De Waele, Elly Marcq, Jinthe Van Loenhout, Eva Lion, Johan M.J. Van den Bergh, Ralf Jesenofsky, Atsushi Masamune, Geert Roeyen, Patrick Pauwels, Filip Lardon, Marc Peeters & Evelien L.J. Smits. (2017) Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells. Oncotarget 8:34, pages 56968-56979.
Crossref
Michael A. Podolsky, Jacob T. Bailey, Andrew J. Gunderson, Carrie J. Oakes, Kyle Breech & Adam B. Glick. (2017) Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-RasG12V–Induced Squamous Tumors. Cancer Immunology Research 5:3, pages 198-210.
Crossref
Daniel Delitto, Andrea E. Delitto, Bayli B. DiVita, Kien Pham, Song Han, Emily R. Hartlage, Brittney N. Newby, Michael H. Gerber, Kevin E. Behrns, Lyle L. Moldawer, Ryan M. Thomas, Thomas J. GeorgeJrJr, Todd M. Brusko, Clayton E. Mathews, Chen Liu, Jose G. Trevino, Steven J. Hughes & Shannon M. Wallet. (2017) Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment. Cancer Research 77:3, pages 672-683.
Crossref
Jae Hyuck Chang, Yongjian Jiang & Venu G. Pillarisetty. (2016) Role of immune cells in pancreatic cancer from bench to clinical application. Medicine 95:49, pages e5541.
Crossref
David J. Birnbaum, Pascal Finetti, Alexia Lopresti, Marine Gilabert, Flora Poizat, Olivier Turrini, Jean-Luc Raoul, Jean-Robert Delpero, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier & François Bertucci. (2016) Prognostic value of PDL1 expression in pancreatic cancer . Oncotarget 7:44, pages 71198-71210.
Crossref
Cristina Jimenez-Luna, Jose Prados, Raul Ortiz, Consolacion Melguizo, Carolina Torres & Octavio Caba. (2016) Current Status of Immunotherapy Treatments for Pancreatic Cancer. Journal of Clinical Gastroenterology 50:10, pages 836-848.
Crossref
Daniel Ansari, Bobby Tingstedt, Bodil Andersson, Fredrik Holmquist, Christian Sturesson, Caroline Williamsson, Agata Sasor, David Borg, Monika Bauden & Roland Andersson. (2016) Pancreatic cancer: yesterday, today and tomorrow. Future Oncology 12:16, pages 1929-1946.
Crossref
Elias Kotteas, Muhammad Wasif Saif & Konstantinos Syrigos. (2016) Immunotherapy for pancreatic cancer. Journal of Cancer Research and Clinical Oncology 142:8, pages 1795-1805.
Crossref
Jorg Kleeff, Murray Korc, Minoti Apte, Carlo La Vecchia, Colin D. Johnson, Andrew V. Biankin, Rachel E. Neale, Margaret Tempero, David A. Tuveson, Ralph H. Hruban & John P. Neoptolemos. (2016) Pancreatic cancer. Nature Reviews Disease Primers 2:1.
Crossref
Oliver Higuera. (2016) Management of pancreatic cancer in the elderly. World Journal of Gastroenterology 22:2, pages 764.
Crossref
A.T. Baines, P.M. Martin & C.J. Rorie. 2016. Molecular and Cellular Changes in the Cancer Cell. Molecular and Cellular Changes in the Cancer Cell 277 320 .
Robert de Wilton Marsh & Marshall S. Baker. 2016. Multimodality Management of Borderline Resectable Pancreatic Cancer. Multimodality Management of Borderline Resectable Pancreatic Cancer 73 89 .
Julia Kravchenko, Emanuela Corsini, Marc A. Williams, William Decker, Masoud H. Manjili, Takemi Otsuki, Neetu Singh, Faha Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A.Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth P. Ryan, Dustin G. Brown, William H. Bisson, Leroy Lowe & H. Kim Lyerly. (2015) Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis 36:Suppl 1, pages S111-S127.
Crossref
Stephen Y Oh. (2015) Rare long-term survivors of pancreatic adenocarcinoma without curative resection. World Journal of Gastroenterology 21:48, pages 13574.
Crossref
Matteo Ligorio, Srinjoy Sil, Jose Malagon-Lopez, Linda T. Nieman, Sandra Misale, Mauro Di Pilato, Murat Karabacak, Anupriya S. Kulkarni, Nicole Vincent Jordan, Joseph Franses, Julia Philipp, Johannes Kreuzer, Niyati Desai, Kshitij S. Arora, Mihir Rajurkar, Richard Y. Ebright, Francesco Marangoni, Myriam Boukhali, Jackson P. Fatherree, Eric Tai, Kevin D. Vo, Chittampalli N. Yashaswini, Leah J. Damon, Kristina Xega, Rushil Desai, Melissa Choz, Francesca Bersani, Robert Morris, Vishal Thapar, Miguel N. Rivera, Vikram Deshpande, Cyril H. Benes, Shyamala Maheswaran, Daniel A. Haber, Carlos Fernandez-Del Castillo, Cristina R. Ferrone, Wilhelm Haas, Martin J. Aryee & David T. Ting. (2018) Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.