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Research Paper

The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

Mattias S. Dahllöf Endocrinology Research Section; Department of Biomedical Sciences; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark
,
Dan P. Christensen Endocrinology Research Section; Department of Biomedical Sciences; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark
,
Morten Lundh Endocrinology Research Section; Department of Biomedical Sciences; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark
,
Charles A. Dinarello Italfarmaco; SpA; Cinisello Balsamo, Italy; Department of Medicine; University of Colorado, Denver; Aurora, CO USA
,
Paolo Mascagni Department of Medicine; University of Colorado, Denver; Aurora, CO USA
,
Lars G. Grunnet Endocrinology Research Section; Department of Biomedical Sciences; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark; Novo Nordisk; Måløv, Denmark
&
Thomas Mandrup-Poulsen Endocrinology Research Section; Department of Biomedical Sciences; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark; Department of Molecular Medicine and Surgery; Karolinska Institutet; Stockholm, SwedenCorrespondence[email protected]
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Pages 417-422 | Published online: 01 Nov 2012

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Linda Sommese, Alberto Zullo, Francesco Paolo Mancini, Rossella Fabbricini, Andrea Soricelli & Claudio Napoli. (2017) Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus. Epigenetics 12:6, pages 401-415.
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Articles from other publishers (10)

Stéphane Dalle, Amar Abderrahmani & Eric Renard. (2023) Pharmacological inhibitors of β-cell dysfunction and death as therapeutics for diabetes. Frontiers in Endocrinology 14.
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Abeer M. Mahmoud. (2022) An Overview of Epigenetics in Obesity: The Role of Lifestyle and Therapeutic Interventions. International Journal of Molecular Sciences 23:3, pages 1341.
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Himavanth Gatla, Nethaji Muniraj, Prashanth Thevkar, Siddhartha Yavvari, Sahithi Sukhavasi & Monish Makena. (2019) Regulation of Chemokines and Cytokines by Histone Deacetylases and an Update on Histone Decetylase Inhibitors in Human Diseases. International Journal of Molecular Sciences 20:5, pages 1110.
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Seyed Mojtaba Ghiasi, Mattias Salling Dahllöf, Yama Osmai, Mirwais Osmai, Kathrine Kronberg Jakobsen, Alexander Aivazidis, Björn Tyrberg, Lisa Perruzza, Michala Cecilie Burstein Prause, Dan Ploug Christensen, Morten Fog-Tonnesen, Morten Lundh, Fabio Grassi, Lucienne Chatenoud & Thomas Mandrup-Poulsen. (2018) Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis. Molecular and Cellular Endocrinology 478, pages 106-114.
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Philip M. Preshaw. (2017) Host modulation therapy with anti‐inflammatory agents. Periodontology 2000 76:1, pages 131-149.
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Alix Besançon, Tania Goncalves, Fabrice Valette, Mattias S. Dahllöf, Thomas Mandrup-Poulsen, Lucienne Chatenoud & Sylvaine You. (2017) Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice. Diabetologia 61:2, pages 389-398.
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Steven G. Gray. 2018. Epigenetics in Human Disease. Epigenetics in Human Disease 489 547 .
Andrix O. Arguelles, Sunitha Meruvu, John D. Bowman & Mahua Choudhury. (2016) Are epigenetic drugs for diabetes and obesity at our door step?. Drug Discovery Today 21:3, pages 499-509.
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Mattias S. DahllöfDan P. ChristensenMette HarvingBridget K. WagnerThomas Mandrup-PoulsenMorten Lundh. (2015) HDAC Inhibitor-Mediated Beta-Cell Protection Against Cytokine-Induced Toxicity Is STAT1 Tyr701 Phosphorylation Independent. Journal of Interferon & Cytokine Research 35:1, pages 63-70.
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M. Lundh, S. S. Scully, T. Mandrup-Poulsen & B. K. Wagner. (2013) Small-molecule inhibition of inflammatory β -cell death . Diabetes, Obesity and Metabolism 15:s3, pages 176-184.
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