The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

References

• Donath MY, Størling J, Berchtold LA, Billestrup N, Mandrup-Poulsen T. Cytokines and beta-cell biology: from concept to clinical translation. Endocr Rev 2008; 29:334 - 50; http://dx.doi.org/10.1210/er.2007-0033; PMID: 18048762
   PubMed Web of Science ®Google Scholar
• Eizirik DL, Mandrup-Poulsen T. A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44:2115 - 33; http://dx.doi.org/10.1007/s001250100021; PMID: 11793013
   PubMed Web of Science ®Google Scholar
• Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, et al. Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab 2008; 93:4065 - 74; http://dx.doi.org/10.1210/jc.2008-0396; PMID: 18664535
   PubMed Web of Science ®Google Scholar
• Dinarello CA, Donath MY, Mandrup-Poulsen T. Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 2010; 17:314 - 21; PMID: 20588114
   PubMed Web of Science ®Google Scholar
• Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007; 356:1517 - 26; http://dx.doi.org/10.1056/NEJMoa065213; PMID: 17429083
   PubMed Web of Science ®Google Scholar
• Roep BO, Kleijwegt FS, van Halteren AG, Bonato V, Boggi U, Vendrame F, et al. Islet inflammation and CXCL10 in recent-onset type 1 diabetes. Clin Exp Immunol 2010; 159:338 - 43; http://dx.doi.org/10.1111/j.1365-2249.2009.04087.x; PMID: 20059481
   PubMed Web of Science ®Google Scholar
• Ribaux P, Ehses JA, Lin-Marq N, Carrozzino F, Böni-Schnetzler M, Hammar E, et al. Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. Endocrinology 2007; 148:5582 - 90; http://dx.doi.org/10.1210/en.2007-0325; PMID: 17702850
   PubMed Web of Science ®Google Scholar
• Uno S, Imagawa A, Saisho K, Okita K, Iwahashi H, Hanafusa T, et al. Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes. Endocr J 2010; 57:991 - 6; http://dx.doi.org/10.1507/endocrj.K10E-076; PMID: 20966598
   PubMed Web of Science ®Google Scholar
• Morimoto J, Yoneyama H, Shimada A, Shigihara T, Yamada S, Oikawa Y, et al. CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitis. J Immunol 2004; 173:7017 - 24; PMID: 15557199
   PubMed Web of Science ®Google Scholar
• Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, et al. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab 2009; 9:125 - 39; http://dx.doi.org/10.1016/j.cmet.2009.01.003; PMID: 19187771
   PubMed Web of Science ®Google Scholar
• Shigihara T, Oikawa Y, Kanazawa Y, Okubo Y, Narumi S, Saruta T, et al. Significance of serum CXCL10/IP-10 level in type 1 diabetes. J Autoimmun 2006; 26:66 - 71; http://dx.doi.org/10.1016/j.jaut.2005.09.027; PMID: 16309891
   PubMed Web of Science ®Google Scholar
• Shimada A, Oikawa Y, Yamada Y, Okubo Y, Narumi S. The role of the CXCL10/CXCR3 system in type 1 diabetes. Rev Diabet Stud 2009; 6:81 - 4; http://dx.doi.org/10.1900/RDS.2009.6.81; PMID: 19806237
   PubMedGoogle Scholar
• Shigihara T, Shimada A, Oikawa Y, Yoneyama H, Kanazawa Y, Okubo Y, et al. CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice. J Immunol 2005; 175:8401 - 8; PMID: 16339582
   PubMed Web of Science ®Google Scholar
• Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009; 325:834 - 40; http://dx.doi.org/10.1126/science.1175371; PMID: 19608861
   PubMed Web of Science ®Google Scholar
• Lundh M, Christensen DP, Rasmussen DN, Mascagni P, Dinarello CA, Billestrup N, et al. Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. Diabetologia 2010; 53:2569 - 78; http://dx.doi.org/10.1007/s00125-010-1892-8; PMID: 20878317
   PubMed Web of Science ®Google Scholar
• Larsen L, Tonnesen M, Ronn SG, Størling J, Jørgensen S, Mascagni P, et al. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia 2007; 50:779 - 89; http://dx.doi.org/10.1007/s00125-006-0562-3; PMID: 17265033
   PubMed Web of Science ®Google Scholar
• Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, et al. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia 2012; 55:2421 - 31; http://dx.doi.org/10.1007/s00125-012-2615-0; PMID: 22772764
   PubMed Web of Science ®Google Scholar
• Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009; 27:519 - 50; http://dx.doi.org/10.1146/annurev.immunol.021908.132612; PMID: 19302047
   PubMed Web of Science ®Google Scholar
• Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009; 183:787 - 91; http://dx.doi.org/10.4049/jimmunol.0901363; PMID: 19570822
   PubMed Web of Science ®Google Scholar
• Yamada Y, Okubo Y, Shimada A, Oikawa Y, Yamada S, Narumi S, et al. Role of CXCR3 in the beta Cell Proliferation in Type 1 Diabetes. Diabetes 2011; 60:Supplement 1 A527
   Google Scholar
• Guo JJ, Li QL, Zhang J, Huang AL. Histone deacetylation is involved in activation of CXCL10 upon IFNgamma stimulation. Mol Cells 2006; 22:163 - 7; PMID: 17085967
   PubMed Web of Science ®Google Scholar
• Kawai T, Takeuchi O, Fujita T, Inoue J, Mühlradt PF, Sato S, et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 2001; 167:5887 - 94; PMID: 11698465
   PubMed Web of Science ®Google Scholar
• Leng C, Gries M, Ziegler J, Lokshin A, Mascagni P, Lentzsch S, et al. Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1. Exp Hematol 2006; 34:776 - 87; http://dx.doi.org/10.1016/j.exphem.2006.02.014; PMID: 16728283
   PubMed Web of Science ®Google Scholar
• Krämer OH, Baus D, Knauer SK, Stein S, Jäger E, Stauber RH, et al. Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev 2006; 20:473 - 85; http://dx.doi.org/10.1101/gad.364306; PMID: 16481475
   PubMed Web of Science ®Google Scholar
• Krämer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Gührs KH, et al. A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev 2009; 23:223 - 35; http://dx.doi.org/10.1101/gad.479209; PMID: 19171783
   PubMed Web of Science ®Google Scholar
• Brunstedt J. Rapid isolation of functionally intact pancreatic islets from mice and rats by percollTM gradient centrifucation. Diabete Metab 1980; 6:87 - 9; PMID: 6250926
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402 - 8; http://dx.doi.org/10.1006/meth.2001.1262; PMID: 11846609
   PubMed Web of Science ®Google Scholar
• Larsen L, Størling J, Darville M, Eizirik DL, Bonny C, Billestrup N, et al. Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells. Diabetologia 2005; 48:2582 - 90; http://dx.doi.org/10.1007/s00125-005-0039-9; PMID: 16283237
   PubMed Web of Science ®Google Scholar