1,971
Views
48
CrossRef citations to date
0
Altmetric
Brief Report

High level expression of functional human IgMs in human PER.C6® cells

, , , , , , , , , , , , , , & show all
Pages 163-171 | Received 30 Nov 2008, Accepted 24 Jan 2009, Published online: 01 Mar 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Xiuhong Piao, Tatsuhiko Ozawa, Hiroshi Hamana, Kiyomi Shitaoka, Aishun Jin, Hiroyuki Kishi & Atsushi Muraguchi. (2016) TRAIL-receptor 1 IgM antibodies strongly induce apoptosis in human cancer cells in vitro and in vivo. OncoImmunology 5:5.
Read now

Articles from other publishers (47)

Gunasekaran Dhandapani, Ellen Wachtel, Ishita Das, Mordechai Sheves & Guy Patchornik. (2022) Conjugated detergent micelles as a platform for IgM purification. Biotechnology and Bioengineering 119:7, pages 1997-2003.
Crossref
Wenbing Zhu, Zhuohang Liu, Xuelin Zheng, Jun Li, Kongjie Lu, Xi Jiang, Xuejian Zhang, Fangfang Ren, Xuemei Zhang, Jingwen Xu, Zhongxiang Wu, Ming Sun & Shaozhong Dong. (2021) A broad and potent IgM antibody against tetra-EV-As induced by EVA71 and CVA16 co-immunization. Vaccine 39:44, pages 6510-6519.
Crossref
Bruce A. Keyt, Ramesh Baliga, Angus M. Sinclair, Stephen F. Carroll & Marvin S. Peterson. (2020) Structure, Function, and Therapeutic Use of IgM Antibodies. Antibodies 9:4, pages 53.
Crossref
Julia Hennicke, Linda Schwaigerlehner, Clemens Grünwald-Gruber, Isabelle Bally, Wai Li Ling, Nicole Thielens, Jean-Baptiste Reiser & Renate Kunert. (2020) Transient pentameric IgM fulfill biological function—Effect of expression host and transfection on IgM properties. PLOS ONE 15:3, pages e0229992.
Crossref
Hannah Reese, Tee Bordelon, Calvin Shanahan, Michael Crapanzano, Jae Sly & Stefano Menegatti. (2020) Novel peptoid-based adsorbents for purifying IgM and IgG from polyclonal and recombinant sources. Journal of Chromatography B 1137, pages 121909.
Crossref
Julia Hennicke & Renate Kunert. 2020. Animal Cell Biotechnology. Animal Cell Biotechnology 295 302 .
Soo Min Noh, Seunghyeon Shin & Gyun Min Lee. 2019. Cell Culture Engineering. Cell Culture Engineering 23 47 .
William C. Yang. 2019. Cell Culture Engineering. Cell Culture Engineering 313 345 .
Edward S.X. Moh, Nima Sayyadi & Nicolle H. Packer. (2019) Chemoenzymatic glycan labelling as a platform for site-specific IgM-antibody drug conjugates. Analytical Biochemistry 584, pages 113385.
Crossref
Alina Rekena, Elina Didrihsone & Kristine Vegere. (2019) The role of magnetic field in the biopharmaceutical production: Current perspectives. Biotechnology Reports 22, pages e00334.
Crossref
Julia Hennicke, David Reinhart, Friedrich Altmann & Renate Kunert. (2019) Impact of temperature and pH on recombinant human IgM quality attributes and productivity. New Biotechnology 50, pages 20-26.
Crossref
Molly Hunter, Ping Yuan, Divya Vavilala & Mark Fox. (2019) Optimization of Protein Expression in Mammalian Cells. Current Protocols in Protein Science 95:1, pages e77.
Crossref
I.K. Piechocka, N.A. Kurniawan, J. Grimbergen, J. Koopman & G.H. Koenderink. (2017) Recombinant fibrinogen reveals the differential roles of α‐ and γ‐chain cross‐linking and molecular heterogeneity in fibrin clot strain‐stiffening. Journal of Thrombosis and Haemostasis 15:5, pages 938-949.
Crossref
Renu Chaudhary, Meenakshi Balhara & Anil Kumar Chhillar. 2017. Metabolic Engineering for Bioactive Compounds. Metabolic Engineering for Bioactive Compounds 73 88 .
Roy Jefferis. 2016. Biosimilars of Monoclonal Antibodies. Biosimilars of Monoclonal Antibodies 155 199 .
Lilian Rumi Tsuruta, Mariana Lopes dos Santos, Fernanda Perez Yeda, Oswaldo Keith Okamoto & Ana Maria Moro. (2016) Genetic analyses of Per.C6 cell clones producing a therapeutic monoclonal antibody regarding productivity and long-term stability. Applied Microbiology and Biotechnology 100:23, pages 10031-10041.
Crossref
Edward S. X. Moh, Chi-Hung Lin, Morten Thaysen-Andersen & Nicolle H. Packer. (2016) Site-Specific N -Glycosylation of Recombinant Pentameric and Hexameric Human IgM . Journal of the American Society for Mass Spectrometry 27:7, pages 1143-1155.
Crossref
Julia Rosenlöcher, Constanze Weilandt, Grit Sandig, Stefan O. Reinke, Véronique Blanchard & Stephan Hinderlich. (2015) The human rhabdomyosarcoma cell line TE671 – Towards an innovative production platform for glycosylated biopharmaceuticals. Protein Expression and Purification 115, pages 83-94.
Crossref
Veronika Chromikova, Alexander Mader, Stefan Hofbauer, Christoph Göbl, Tobias Madl, Johannes S. Gach, Stefan Bauernfried, Paul G. Furtmüller, Donald N. Forthal, Lukas Mach, Christian Obinger & Renate Kunert. (2015) Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1854:10, pages 1536-1544.
Crossref
Rafael Tagé Biaggio, Mário Soares Abreu-Neto, Dimas Tadeu Covas & Kamilla Swiech. (2015) Serum-free suspension culturing of human cells: adaptation, growth, and cryopreservation. Bioprocess and Biosystems Engineering 38:8, pages 1495-1507.
Crossref
Sarah M. Mercier, Bas Diepenbroek, Dirk Martens, Rene H. Wijffels & Mathieu Streefland. (2015) Characterization of apoptosis in PER.C6® batch and perfusion cultures. Biotechnology and Bioengineering 112:3, pages 569-578.
Crossref
Bérengère Vire, Martin Skarzynski, Joshua D. Thomas, Christopher G. Nelson, Alexandre David, Georg Aue, Terrence R. BurkeJrJr, Christoph Rader & Adrian Wiestner. (2014) Harnessing the Fcμ Receptor for Potent and Selective Cytotoxic Therapy of Chronic Lymphocytic Leukemia. Cancer Research 74:24, pages 7510-7520.
Crossref
Yeng Chen, Siti Nuraishah Azman, Jesinda P. Kerishnan, Rosnah Binti Zain, Yu Nieng Chen, Yin-Ling Wong & Subash C. B. Gopinath. (2014) Identification of Host-Immune Response Protein Candidates in the Sera of Human Oral Squamous Cell Carcinoma Patients. PLoS ONE 9:10, pages e109012.
Crossref
Tomasz Kowalczyk, Katarzyna Hnatuszko-Konka, Aneta Gerszberg & Andrzej K. Kononowicz. (2014) Elastin-like polypeptides as a promising family of genetically-engineered protein based polymers. World Journal of Microbiology and Biotechnology 30:8, pages 2141-2152.
Crossref
Andrew Hiatt. (2014) Designed IgM from glycoengineering. Proceedings of the National Academy of Sciences 111:17, pages 6124-6125.
Crossref
Andreas LoosClemens GruberFriedrich AltmannUlrich MehoferFrank Hensel, Melanie Grandits, Chris Oostenbrink, Gerhard StadlmayrPaul G. FurtmüllerHerta Steinkellner. (2014) Expression and glycoengineering of functionally active heteromultimeric IgM in plants. Proceedings of the National Academy of Sciences 111:17, pages 6263-6268.
Crossref
Roy Jefferis. 2014. State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 1. Monoclonal Antibody Therapeutics: Structure, Function, and Regulatory Space. State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 1. Monoclonal Antibody Therapeutics: Structure, Function, and Regulatory Space 35 68 .
Leo Rasche, Johannes Duell, Charlotte Morgner, Manik Chatterjee, Frank Hensel, Andreas Rosenwald, Hermann Einsele, Max S. Topp & Stephanie Br?ndlein. (2013) The Natural Human IgM Antibody PAT-SM6 Induces Apoptosis in Primary Human Multiple Myeloma Cells by Targeting Heat Shock Protein GRP78. PLoS ONE 8:5, pages e63414.
Crossref
Zachary Rosenes, Yee-Foong Mok, Shuo Yang, Michael D. W. Griffin, Terrence D. Mulhern, Danny M. Hatters, Frank Hensel & Geoffrey J. Howlett. (2013) Simultaneous Binding of the Anti-Cancer IgM Monoclonal Antibody PAT-SM6 to Low Density Lipoproteins and GRP78. PLoS ONE 8:4, pages e61239.
Crossref
Peter C. Jones. (2013) Does a “thiol shield” protect tumors from natural IgM antibody, and, if so, how can it be suppressed?. Medical Hypotheses 80:4, pages 425-430.
Crossref
Alexander Mader, Veronika Chromikova & Renate Kunert. (2013) Recombinant IgM expression in mammalian cells: A target protein challenging biotechnological production. Advances in Bioscience and Biotechnology 04:04, pages 38-43.
Crossref
David Ross, Tonya Brown, Richard Harper, Mohan Pamarthi, Jennifer Nixon, John Bromirski, Cheng-Ming Li, Reham Ghali, Hongbo Xie, Gene Medvedeff, Hongbin Li, Philip Scuderi, Vik Arora, Jennifer Hunt & Thomas Barnett. (2012) Production and characterization of a novel human recombinant alpha-1-antitrypsin in PER.C6 cells. Journal of Biotechnology 162:2-3, pages 262-273.
Crossref
Roy Jefferis. (2012) Isotype and glycoform selection for antibody therapeutics. Archives of Biochemistry and Biophysics 526:2, pages 159-166.
Crossref
Simon Fischer, Nadine Charara, Andrea Gerber, Jens Wölfel, Gudrun Schiedner, Bernd Voedisch & Sabine Geisse. (2012) Transient recombinant protein expression in a human amniocyte cell line: The CAP-T® cell system. Biotechnology and Bioengineering 109:9, pages 2250-2261.
Crossref
Linda H. L. Lua & Yap Pang Chuan. 2012. Biopharmaceutical Production Technology. Biopharmaceutical Production Technology 43 77 .
Kamilla Swiech, Virg?nia Pican?o-Castro & Dimas Tadeu Covas. (2012) Human cells: New platform for recombinant therapeutic protein production. Protein Expression and Purification 84:1, pages 147-153.
Crossref
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 421 595 .
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 197 595 .
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 459 595 .
Sabine Geisse & Bernd Voedisch. 2012. Therapeutic Proteins. Therapeutic Proteins 203 219 .
Leodevico L. Ilag. (2011) Immunoglobulin M as a vaccine adjuvant. Medical Hypotheses 77:4, pages 473-478.
Crossref
Jody D. Berry & Ryan G. Gaudet. (2011) Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology. New Biotechnology 28:5, pages 489-501.
Crossref
Yabing Cao, Yongsheng Lan, Jianfei Qian, Yuhuan Zheng, Sungyoul Hong, Haiyan Li, Michael Wang, Larry W. Kwak, Dongyu Lin, Jing Yang & Qing Yi. (2011) Targeting cell surface ?2-microglobulin by pentameric IgM antibodies. British Journal of Haematology 154:1, pages 111-121.
Crossref
Rachael Racine, Maura McLaughlin, Derek D. Jones, Susan T. Wittmer, Katherine C. MacNamara, David L. Woodland & Gary M. Winslow. (2011) IgM Production by Bone Marrow Plasmablasts Contributes to Long-Term Protection against Intracellular Bacterial Infection. The Journal of Immunology 186:2, pages 1011-1021.
Crossref
John de Kruif, Arjen Kramer, Roy Nijhuis, Vanessa van der Zande, Renate den Blanken, Carina Clements, Therèse Visser, Rob Keehnen, Marcel den Hartog, Mark Throsby & Ton Logtenberg. (2010) Generation of stable cell clones expressing mixtures of human antibodies. Biotechnology and Bioengineering 106:5, pages 741-750.
Crossref
Lisette A. H. M. Cornelissen, Robert P. de Vries, Els A. de Boer-Luijtze, Alan Rigter, Peter J. M. Rottier & Cornelis A. M. de Haan. (2010) A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1. PLoS ONE 5:5, pages e10645.
Crossref
Michael C. FlickingerMarco A. Cacciuttolo, Gene Lee, John Chon & John Lewis. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 12 .