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mAbs Volume 5, 2013 - Issue 5
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Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease

Lydia Giménez-Llort Institut de Neurociències; Unitat de Biociències; Universitat Autònoma de Barcelona; Barcelona, Spain; Departament de Psiquiatria i Medicina Legal; Unitat de Biociències; Universitat Autònoma de Barcelona; Barcelona, Spain
,
Geovanny Rivera-Hernández Protein Folding and Stability Group; Departament de Bioquímica i Biologia Molecular; Unitat de Biociències; Universitat Autònoma de Barcelona; Barcelona, Spain
,
Marta Marín-Argany Protein Folding and Stability Group; Departament de Bioquímica i Biologia Molecular; Unitat de Biociències; Universitat Autònoma de Barcelona; Barcelona, Spain
,
José L. Sánchez-Quesada Servei de Bioquímica; Institut de Investigació Biomèdica Sant Pau (IIB Sant Pau); Barcelona, Spain
&
Sandra Villegas Protein Folding and Stability Group; Departament de Bioquímica i Biologia Molecular; Unitat de Biociències; Universitat Autònoma de Barcelona; Barcelona, SpainCorrespondence[email protected]
Pages 665-864 | Received 14 May 2013, Accepted 15 Jun 2013, Published online: 20 Jun 2013

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Laia Montoliu-Gaya, Javier Murciano-Calles, Jose C. Martinez & Sandra Villegas. (2017) Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential. Amyloid 24:3, pages 167-175.
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Gisela Esquerda-Canals, Joaquim Marti, Geovanny Rivera-Hernández, Lydia Giménez-Llort & Sandra Villegas. (2013) Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment. mAbs 5:5, pages 660-664.
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Articles from other publishers (41)

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Zhi-Ting Sun, Chi Ma, Guang-Jian Li, Xiang-Yu Zheng, Yi-Tong Hao, Yu Yang & Xu Wang. (2021) Application of Antibody Fragments Against Aβ With Emphasis on Combined Application With Nanoparticles in Alzheimer’s Disease. Frontiers in Pharmacology 12.
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Alejandro R. Roda, Gisela Esquerda-Canals, Joaquim Martí-Clúa & Sandra Villegas. (2020) Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer’s Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation. Pharmaceutics 12:10, pages 944.
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Alejandro R. Roda, Laia Montoliu-Gaya, Gabriel Serra-Mir & Sandra Villegas. (2020) Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice. International Journal of Molecular Sciences 21:18, pages 6630.
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Senthilkumar Krishnaswamy, Huai-Wei Huang, Isabella S. Marchal, Hyung Don Ryoo & Einar M. Sigurdsson. (2020) Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models. Neurobiology of Disease 137, pages 104770.
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Lidia Castillo-Mariqueo & Lydia Giménez-Llort. (2020) Indexes for flotation and circling, two non-search behaviors in the water maze, sensitive to d-galactose–induced accelerated aging and Alzheimer’s disease. Behavioural Brain Research 377, pages 112229.
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Yun-Zhou Yu, Si Liu, Hai-Chao Wang, DanYang Shi, Qing Xu, Xiao-Wei Zhou, Zhi-Wei Sun & Pei-Tang Huang. (2016) A Novel Aβ B-Cell Epitope Vaccine (rCV01) for Alzheimer’s Disease Improved Synaptic and Cognitive Functions in 3 × Tg-AD Mice. Journal of Neuroimmune Pharmacology 11:4, pages 657-668.
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Yun-Zhou Yu, Si Liu, Hai-Chao Wang, Dan-Yang Shi, Qing Xu, Xiao-Wei Zhou, Zhi-Wei Sun & Pei-Tang Huang. (2016) A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer’s disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice. Scientific Reports 6:1.
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Cheng Zhang, Ching‐Chang Kuo, Setareh H. Moghadam, Louise Monte, Shannon N. Campbell, Kenner C. Rice, Paul E. Sawchenko, Eliezer Masliah & Robert A. Rissman. (2015) Corticotropin‐releasing factor receptor‐1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimer's & Dementia 12:5, pages 527-537.
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Laia Montoliu-Gaya & Sandra Villegas. (2016) A β -Immunotherapeutic strategies: a wide range of approaches for Alzheimer's disease treatment . Expert Reviews in Molecular Medicine 18.
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Juan I. Castrillo & Stephen G. Oliver. 2016. Systems Biology of Alzheimer's Disease. Systems Biology of Alzheimer's Disease 3 48 .
Yuan Zhang, Xu Chen, Jinyu Liu & Yingjiu Zhang. (2015) The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody. Neuropharmacology 99, pages 387-395.
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Pedro Fernandez-Funez, Yan Zhang, Jonatan Sanchez-Garcia, Lorena de Mena, Swati Khare, Todd E. Golde, Yona Levites & Diego E. Rincon-Limas. (2015) Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease . Human Molecular Genetics 24:21, pages 6093-6105.
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Sandra Villegas. (2015) Enfermedad de Alzheimer: nuevas estrategias terapéuticas. Medicina Clínica 145:2, pages 76-83.
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