mAbs, Volume 5, Issue 5 (2013)

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mAbs, Volume 5, Issue 5 (2013)

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Editorial

Editorial
Approval of the first biosimilar antibodies in Europe
A major landmark for the biopharmaceutical industry
Alain Beck & Janice M. Reichert
Pages: 621-623
Published online: 24 Jul 2013
AbstractforApproval of the first biosimilar antibodies in Europe | Full Text | References | PDF (125 KB)
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Letter to the Editor

Letter
Characterization and comparison of commercially available TNF receptor 2-Fc fusion protein products
Letter to the Editor
Brian Hassett, Scott McMillen & Brian Fitzpatrick
Pages: 624-625
Published online: 07 Aug 2013
CitationforCharacterization and comparison of commercially available TNF receptor 2-Fc fusion protein products | Full Text | References | PDF (103.6 KB)
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Meeting Report

Meeting Report
Therapeutic antibodies and infectious diseases, Tours, France, November 20−22, 2012
Guillaume Desoubeaux, Arnaud Daguet & Hervé Watier
Pages: 626-632
Published online: 07 Jun 2013
AbstractforTherapeutic antibodies and infectious diseases, Tours, France, November 20−22, 2012 | Full Text | References | PDF (189.1 KB)
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Meeting Report
From Bretonneau to therapeutic antibodies, from specificity to specific remedies, Saint-Cyr-Sur-Loire, France, November 19, 2012
Claire Marchand, Romaric Nouat & Hervé Watier
Pages: 633-637
Published online: 08 Jul 2013
AbstractforFrom Bretonneau to therapeutic antibodies, from specificity to specific remedies, Saint-Cyr-Sur-Loire, France, November 19, 2012 | Full Text | References | PDF (355.9 KB)
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Book Review

Review of Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols
A book edited by Alain Beck
Roy Jefferis
Pages: 638-640
Published online: 03 Jul 2013
AbstractforReview of Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols | Full Text | References | PDF (125.6 KB)
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Brief Report

Brief Report
Rapid Fc glycosylation analysis of Fc fusions with IdeS and liquid chromatography mass spectrometry
Heather Lynaugh, Huijuan Li & Bing Gong
Pages: 641-645
Published online: 20 Jun 2013
AbstractforRapid Fc glycosylation analysis of Fc fusions with IdeS and liquid chromatography mass spectrometry | Full Text | References | PDF (987.1 KB)
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Short Communication

Brief Report
Improving biophysical properties of a bispecific antibody scaffold to aid developability
Quality by molecular design
Thomas Spreter Von Kreudenstein, Eric Escobar-Carbrera, Paula I. Lario, Igor D’Angelo, Karine Brault, John F Kelly, Yves Durocher, Jason Baardsnes, R. Jeremy Woods, Michael Hongwei Xie, Pierre-Alain Girod, Michael D. L. Suits, Martin J. Boulanger, David K. Y. Poon, Gordon Y. Ng & Surjit B. Dixit
Pages: 646-654
Published online: 08 Jul 2013
AbstractforImproving biophysical properties of a bispecific antibody scaffold to aid developability | Full Text | References | PDF (3.7 MB) | Supplemental
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Brief Report
Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis
Dilip K. Challa, Uta Bussmeyer, Tarique Khan, Héctor P. Montoyo, Pankaj Bansal, Raimund J. Ober & E Sally Ward
Pages: 655-659
Published online: 19 Jun 2013
AbstractforAutoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis | Full Text | References | PDF (885.7 KB)
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Brief Report
Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment
Gisela Esquerda-Canals, Joaquim Marti, Geovanny Rivera-Hernández, Lydia Giménez-Llort & Sandra Villegas
Pages: 660-664
Published online: 20 Jun 2013
AbstractforLoss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment | Full Text | References | PDF (388.6 KB)
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Report

Article
Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease
Lydia Giménez-Llort, Geovanny Rivera-Hernández, Marta Marín-Argany, José L. Sánchez-Quesada & Sandra Villegas
Pages: 665-864
Published online: 20 Jun 2013
AbstractforEarly intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease | Full Text | References | PDF (1.9 MB)
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Article
Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency
Geovanny Rivera-Hernández, Marta Marín-Argany, Bernat Blasco-Moreno, Jaume Bonet, Baldomero Oliva & Sandra Villegas
Pages: 678-689
Published online: 19 Jun 2013
AbstractforElongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency | Full Text | References | PDF (981.5 KB)
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Article
Comparing CDRH3 diversity captured from secondary lymphoid organs for the generation of recombinant human antibodies
Sophie Venet, Marie Kosco-Vilbois & Nicolas Fischer
Pages: 690-698
Published online: 02 Jul 2013
AbstractforComparing CDRH3 diversity captured from secondary lymphoid organs for the generation of recombinant human antibodies | Full Text | References | PDF (2.6 MB) | Supplemental
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Article
Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques
Daniel Ayoub, Wolfgang Jabs, Anja Resemann, Waltraud Evers, Catherine Evans, Laura Main, Carsten Baessmann, Elsa Wagner-Rousset, Detlev Suckau & Alain Beck
Pages: 699-710
Published online: 20 Jun 2013
AbstractforCorrect primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques | Full Text | References | PDF (8.9 MB) | Supplemental
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Article
LC-MS characterization and purity assessment of a prototype bispecific antibody
R. Jeremy Woods, Michael Hongwei Xie, Thomas Spreter Von Kreudenstein, Gordon Y. Ng & Surjit B. Dixit
Pages: 711-722
Published online: 24 Jun 2013
AbstractforLC-MS characterization and purity assessment of a prototype bispecific antibody | Full Text | References | PDF (4.3 MB)
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Article
Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies
Sarwish Rafiq, Anthony Siadak, Jonathan P. Butchar, Carolyn Cheney, Gerard Lozanski, Naduparambil K. Jacob, Rosa Lapalombella, Jackie McGourty, Meghan Moledor, Richard Lowe, Ben Setter, Jeffrey Jones, Joseph M. Flynn, Leslie Andritsos, Steven Devine, Xiaokui Mo, David Jarjoura, Susheela Tridandapani, Paul Algate, John C. Byrd & Natarajan Muthusamy
Pages: 723-735
Published online: 07 Jun 2013
AbstractforGlycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies | Full Text | References | PDF (1 MB)
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Article
A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells
Hélène Haegel, Christine Thioudellet, Rémy Hallet, Michel Geist, Thierry Menguy, Fabrice Le Pogam, Jean-Baptiste Marchand, Myew-Ling Toh, Vanessa Duong, Alexandre Calcei, Nathalie Settelen, Xavier Preville, Marie Hennequi, Benoit Grellier, Philippe Ancian, Jukka Rissanen, Pascal Clayette, Christine Guillen, Ronald Rooke & Jean-Yves Bonnefoy
Pages: 736-747
Published online: 15 Jul 2013
AbstractforA unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells | Full Text | References | PDF (2.5 MB) | Supplemental
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Article
Affinity-matured recombinant immunotoxin targeting gangliosides 3′-isoLM1 and 3′,6'-isoLD1 on malignant gliomas
Hailan Piao, Chien-Tsun Kuan, Vidya Chandramohan, Stephen T Keir, Charles N Pegram, Xuhui Bao, Jan-Eric Månsson, Ira H Pastan & Darell D Bigner
Pages: 748-762
Published online: 25 Jul 2013
AbstractforAffinity-matured recombinant immunotoxin targeting gangliosides 3′-isoLM1 and 3′,6'-isoLD1 on malignant gliomas | Full Text | References | PDF (3.6 MB) | Supplemental
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Article
Cloning and expression of an anti-LDL(-) single-chain variable fragment, and its inhibitory effect on experimental atherosclerosis
Soraya M Kazuma, Marcela F Cavalcante, Andréia ER Telles, Andrea Queiroz Maranhão & Dulcineia SP Abdalla
Pages: 763-775
Published online: 25 Jul 2013
AbstractforCloning and expression of an anti-LDL(-) single-chain variable fragment, and its inhibitory effect on experimental atherosclerosis | Full Text | References | PDF (1.8 MB)
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Article
Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys
Vladimir Vexler, Li Yu, Chandrasena Pamulapati, Rosario Garrido, Hans Peter Grimm, Priya Sriraman, Sandhya Bohini, Michael Schraeml, Usha Singh, Michael Brandt, Stefan Ries, Han Ma, Klaus Klumpp & Changhua Ji
Pages: 776-786
Published online: 08 Jul 2013
AbstractforTarget-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys | Full Text | References | PDF (4.8 MB) | Supplemental
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Article
Developability studies before initiation of process development
Improving manufacturability of monoclonal antibodies
Xiaoyu Yang, Wei Xu, Svetlana Dukleska, Sabrina Benchaar, Selina Mengisen, Valentyn Antochshuk, Jason Cheung, Leslie Mann, Zulfia Babadjanova, Jason Rowand, Rico Gunawan, Alexander McCampbell, Maribel Beaumont, David Meininger, Daisy Richardson & Alexandre Ambrogelly
Pages: 787-794
Published online: 07 Jun 2013
AbstractforDevelopability studies before initiation of process development | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
Purification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions
Sanchayita Ghose, Yinying Tao, Lynn Conley & Douglas Cecchini
Pages: 795-800
Published online: 26 Jun 2013
AbstractforPurification of monoclonal antibodies by hydrophobic interaction chromatography under no-salt conditions | Full Text | References | PDF (676.9 KB)
  • 6151 Views
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Article
Ch14.18 antibody produced in CHO cells in relapsed or refractory Stage 4 neuroblastoma patients
A SIOPEN Phase 1 study
Ruth Ladenstein, Silke Weixler, Bianca Baykan, Matthias Bleeke, Renate Kunert, Dietmar Katinger, Ingrid Pribill, Petra Glander, Steffen Bauer, Vito Pistoia, Jean Michon, Alberto Garaventa & Holger N. Lode
Pages: 801-809
Published online: 31 May 2013
AbstractforCh14.18 antibody produced in CHO cells in relapsed or refractory Stage 4 neuroblastoma patients | Full Text | References | PDF (1.3 MB)
  • 2110 Views
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Article
Immunogenicity of mAbs in non-human primates during nonclinical safety assessment
Peter J.K. van Meer, Marlous Kooijman, Vera Brinks, Christine C. Gispen-de Wied, Beatriz Silva-Lima, Ellen H.M. Moors & Huub Schellekens
Pages: 810-816
Published online: 06 Jun 2013
AbstractforImmunogenicity of mAbs in non-human primates during nonclinical safety assessment | Full Text | References | PDF (167.2 KB)
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