Advanced search
Publication Cover
mAbs Volume 5, 2013 - Issue 5
Submit an article Journal homepage
1,543
Views
10
CrossRef citations to date
0
Altmetric
Report

Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys

Vladimir Vexler Non-Clinical Safety; Nutley, NJ USA
,
Li Yu Non-Clinical Safety; Nutley, NJ USACorrespondence[email protected]
,
Chandrasena Pamulapati Non-Clinical Safety; Nutley, NJ USA
,
Rosario Garrido Non-Clinical Safety; Nutley, NJ USA
,
Hans Peter Grimm Non-Clinical Safety; Basel, Switzerland
,
Priya Sriraman Non-Clinical Safety; Nutley, NJ USA
,
Sandhya Bohini Virology Disease and Translational Area, Nutley, NJ USA
,
Michael Schraeml Large Molecule Research; F. Hoffman-La Roche, Ltd.; Penzberg, Germany
,
Usha Singh Non-Clinical Safety; Nutley, NJ USA
,
Michael Brandt Large Molecule Research; F. Hoffman-La Roche, Ltd.; Penzberg, Germany
,
Stefan Ries Large Molecule Research; F. Hoffman-La Roche, Ltd.; Penzberg, Germany
,
Han Ma Virology Disease and Translational Area, Nutley, NJ USA
,
Klaus Klumpp Virology Disease and Translational Area, Nutley, NJ USA
&
Changhua Ji Virology Disease and Translational Area, Nutley, NJ USA
 show all
Pages 776-786 | Received 08 Jun 2013, Accepted 05 Jul 2013, Published online: 08 Jul 2013

Citations (10)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Charlotte Bon, Thomas Hofer, Alain Bousquet-Mélou, Mark R. Davies & Ben-Fillippo Krippendorff. (2017) Capacity limits of asialoglycoprotein receptor-mediated liver targeting. mAbs 9:8, pages 1360-1369.
Read now
Alexander Bujotzek, Florian Lipsmeier, Seth F Harris, Jörg Benz, Andreas Kuglstatter & Guy Georges. (2016) VH-VL orientation prediction for antibody humanization candidate selection: A case study. mAbs 8:2, pages 288-305.
Read now

Articles from other publishers (8)

Christian Bailly & Xavier Thuru. (2023) Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases. Cancers 15:7, pages 2186.
Crossref
Thanawat Suwatthanarak, Kei Usuba, Kotomi Kuroha, Masayoshi Tanaka & Mina Okochi. (2023) Screening of EWI-2-Derived Peptides for Targeting Tetraspanin CD81 and Their Effect on Cancer Cell Migration. Biomolecules 13:3, pages 510.
Crossref
Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage & Timothy S. Tracy. (2022) Pharmacokinetic Modeling of Warfarin І – Model-Based Analysis of Warfarin Enantiomers with a Target Mediated Drug Disposition Model Reveals CYP2C9 Genotype-Dependent Drug-Drug Interactions of S-Warfarin . Drug Metabolism and Disposition 50:9, pages 1287-1301.
Crossref
Wang Zheng, Qianping Chen, Hongxia Liu, Songling Hu, Yuchuan Zhou, Yang Bai, Jianghong Zhang, Yan Pan & Chunlin Shao. (2021) CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51. Cancers 13:9, pages 1998.
Crossref
Kenta Haraya, Tatsuhiko Tachibana & Tomoyuki Igawa. (2019) Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering. Drug Metabolism and Pharmacokinetics 34:1, pages 25-41.
Crossref
Andrew T. Lucas, Ryan Robinson, Allison N. Schorzman, Joseph A. Piscitelli, Juan F. Razo & William C. Zamboni. (2019) Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients. Antibodies 8:1, pages 3.
Crossref
Felipe Vences-CatalánCaroline DuaultChiung-Chi KuoRanjani RajapaksaRonald LevyShoshana Levy. (2017) CD81 as a tumor target. Biochemical Society Transactions 45:2, pages 531-535.
Crossref
P Dua, E Hawkins & PH van der Graaf. (2015) A Tutorial on Target-Mediated Drug Disposition (TMDD) Models. CPT: Pharmacometrics & Systems Pharmacology 4:6, pages 324-337.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.