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Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects

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Pages 273-285 | Received 17 Sep 2013, Accepted 15 Nov 2013, Published online: 19 Nov 2013

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Gertrudis Rojas, Yaima Tundidor & Yanelys Cabrera Infante. (2014) High throughput functional epitope mapping: Revisiting phage display platform to scan target antigen surface. mAbs 6:6, pages 1368-1376.
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Yaima Tundidor, Claudia Patricia García-Hernández, Amaury Pupo, Yanelys Cabrera Infante & Gertrudis Rojas. (2014) Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor. mAbs 6:4, pages 1013-1025.
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Yanelys Cabrera Infante, Amaury Pupo & Gertrudis Rojas. (2014) A combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen. mAbs 6:3, pages 637-648.
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Articles from other publishers (19)

Gertrudis Rojas, Tania Carmenate, Gisela García-Pérez & Dayana Pérez-Martínez. 2023. Phage Display. Phage Display 149 189 .
Gertrudis Rojas. (2022) Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology. Antibodies 11:3, pages 48.
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Prashant Chauhan, Arathi Nair, Ashok Patidar, Jagneshwar Dandapat, Arup Sarkar & Bhaskar Saha. (2021) A primer on cytokines. Cytokine 145, pages 155458.
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Ruihe Wu, Na Li, Xiangcong Zhao, Tingting Ding, Hongwei Xue, Chong Gao, Xiaofeng Li & Caihong Wang. (2020) Low-dose Interleukin-2: Biology and therapeutic prospects in rheumatoid arthritis. Autoimmunity Reviews 19:10, pages 102645.
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Naoko Imai, Isao Tawara, Makiko Yamane, Daisuke Muraoka, Hiroshi Shiku & Hiroaki Ikeda. (2020) CD4 + T cells support polyfunctionality of cytotoxic CD8 + T cells with memory potential in immunological control of tumor . Cancer Science 111:6, pages 1958-1968.
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Jonathan Zorea, Rajendra P. Shukla, Moshe Elkabets & Hadar Ben-Yoav. (2020) Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Analytical and Bioanalytical Chemistry 412:7, pages 1709-1717.
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Yaima Tundidor, Luis F. Ponce, Lisset Chao, Joaquín Solozábal, Michael Hust, Stefan Dübel & Gertrudis Rojas. (2020) Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity. Scientific Reports 10:1.
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Le Xu, Xiaolei Song, Lili Su, Yong Zheng, Ru Li & Jian Sun. (2019) New therapeutic strategies based on IL-2 to modulate Treg cells for autoimmune diseases. International Immunopharmacology 72, pages 322-329.
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Svetlana G. Semushina, Dmitry A. Aronov & Ekaterina V. Moiseeva. (2018) Local Interleukin-2 Immunotherapy of Breast Cancer: Benefit and Risk in a Spontaneous Mouse Model. Pathology & Oncology Research 25:3, pages 945-951.
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Andrew M. Wollacott, Luke N. Robinson, Boopathy Ramakrishnan, Hamid Tissire, Karthik Viswanathan, Zachary Shriver & Gregory J. Babcock. (2019) Structural prediction of antibody-APRIL complexes by computational docking constrained by antigen saturation mutagenesis library data. Journal of Molecular Recognition 32:7, pages e2778.
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Gertrudis Rojas, Tania Carmenate, Julio Felipe Santo-Tomás, Pedro A. Valiente, Marlies Becker, Annia Pérez-Riverón, Yaima Tundidor, Yaquelín Ortiz, Jorge Fernandez de Cossio-Diaz, Luis Graça, Stefan Dübel & Kalet León. (2019) Directed evolution of super-secreted variants from phage-displayed human Interleukin-2. Scientific Reports 9:1.
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Miao Shao, Xiao-Lin Sun, He Sun, Jing He, Rui-Jun Zhang, Xia Zhang & Zhan-Guo Li. (2018) Clinical Relevance of Autoantibodies against Interleukin-2 in Patients with Systemic Lupus Erythematosus. Chinese Medical Journal 131:13, pages 1520-1526.
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Tania Carmenate, Yaquelín Ortíz, Michel Enamorado, Karina García-Martínez, Janet Avellanet, Ernesto Moreno, Luis Graça & Kalet León. (2018) Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells. The Journal of Immunology 200:10, pages 3475-3484.
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Kalet León, Karina García-Martínez, Tania Carmenate & Gertrudis Rojas. (2018) Combining computational and experimental biology to develop therapeutically valuable IL2 muteins. Seminars in Oncology 45:1-2, pages 95-104.
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Gertrudis Rojas & Tania Carmenate. 2018. Phage Display. Phage Display 535 560 .
Pooja Dhupkar & Nancy Gordon. 2017. Immunotherapy. Immunotherapy 33 51 .
Jamie B. Spangler, Jakub Tomala, Vincent C. Luca, Kevin M. Jude, Shen Dong, Aaron M. Ring, Petra Votavova, Marion Pepper, Marek Kovar & K. Christopher Garcia. (2015) Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity 42:5, pages 815-825.
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Gertrudis Rojas, Tania Carmenate & Kalet Leon. (2015) Molecular dissection of the interactions of an antitumor interleukin-2-derived mutein on a phage display-based platform. Journal of Molecular Recognition 28:4, pages 261-268.
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Petra Votavova, Jakub Tomala & Marek Kovar. (2014) Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera. Immunology Letters 159:1-2, pages 1-10.
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