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A new class of bispecific antibodies to redirect T cells for cancer immunotherapy

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Pages 381-391 | Received 15 Oct 2013, Accepted 01 Dec 2013, Published online: 02 Dec 2013

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Sergey E Sedykh, Victor V Prinz, Valentina N Buneva & Georgy A Nevinsky. (2018) Bispecific antibodies: design, therapy, perspectives. Drug Design, Development and Therapy 12, pages 195-208.
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Troy A McEachron, Timothy J Triche, Laurie Sorenson, David M Parham & John D Carpten. (2018) Profiling targetable immune checkpoints in osteosarcoma. OncoImmunology 7:12.
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Archana Thakur & Lawrence G. Lum. (2016) “NextGen” Biologics: Bispecific Antibodies and Emerging Clinical Results. Expert Opinion on Biological Therapy 16:5, pages 675-688.
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Mahiuddin Ahmed, Ming Cheng, Irene Y Cheung & Nai-Kong V Cheung. (2015) Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody. OncoImmunology 4:4.
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Giuseppe Di Caro, Giovanni Francesco Castino, Francesca Bergomas, Nina Cortese, Maurizio Chiriva-Internati, Fabio Grizzi & Federica Marchesi. (2014) Immune-based therapies in pancreatic and colorectal cancers and biomarkers of responsiveness. Expert Review of Anticancer Therapy 14:10, pages 1219-1228.
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Joshua F. Meckler, Daniel J. Levis, Daniel P. Vang & Joseph M. Tuscano. (2023) A Novel bispecific T-cell engager (BiTE) targeting CD22 and CD3 has both in vitro and in vivo activity and synergizes with blinatumomab in an acute lymphoblastic leukemia (ALL) tumor model. Cancer Immunology, Immunotherapy 72:9, pages 2939-2948.
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Rebecca Epperly, Stephen Gottschalk & M. Paulina Velasquez. 2022. Gene and Cellular Immunotherapy for Cancer. Gene and Cellular Immunotherapy for Cancer 329 351 .
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Seil Jang, Jaeho Song, NaYoung Kim, Jeonghyeon Bak, Keehoon Jung, Young Woo Park, Bum-Chan Park & Ho Min Kim. (2021) Development of an antibody-like T-cell engager based on VH-VL heterodimer formation and its application in cancer therapy. Biomaterials 271, pages 120760.
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Fadi Haddad & Naval Daver. 2021. Immunotherapy. Immunotherapy 273 295 .
Siwei Nie, Zhuozhi Wang, Maria Moscoso-Castro, Paul D'Souza, Can Lei, Jianqing Xu & Jijie Gu. (2020) Biology drives the discovery of bispecific antibodies as innovative therapeutics. Antibody Therapeutics 3:1, pages 18-62.
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S. E. Sedykh & G. A. Nevinsky. (2019) Producing and prospects for the use of bispecific antibodies for the treatment of cancer. Advances in molecular oncology 5:4, pages 30-40.
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Bing Zhou, Longfa Xu, Rui Zhu, Jixian Tang, Yangtao Wu, Ruopeng Su, Zhichao Yin, Dongxiao Liu, Yichao Jiang, Can Wen, Min You, Linlin Dai, Yu Lin, Yuanzhi Chen, Haijie Yang, Zhiqiang An, Changfa Fan, Tong Cheng, Wenxin Luo & Ningshao Xia. (2019) A bispecific broadly neutralizing antibody against enterovirus 71 and coxsackievirus A16 with therapeutic potential. Antiviral Research 161, pages 28-35.
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Lilach Vaks, Dana Litvak-Greenfeld, Stav Dror, Galia Matatov, Limor Nahary, Shiran Shapira, Rahely Hakim, Iris Alroy & Itai Benhar. (2018) Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds. Antibodies 7:3, pages 27.
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David M. Goldenberg, Rhona Stein & Robert M. Sharkey. (2018) The emergence of trophoblast cell-surface antigen 2 (TROP-2) as a novel cancer target. Oncotarget 9:48, pages 28989-29006.
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Markus Kieler, Matthias Unseld, Daniela Bianconi & Gerald Prager. (2018) Challenges and Perspectives for Immunotherapy in Adenocarcinoma of the Pancreas. Pancreas 47:2, pages 142-157.
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Z. Wu & N.V. Cheung. (2018) T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics. Pharmacology & Therapeutics 182, pages 161-175.
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Yumei Li, Changhua Zhou, Jing Li, Jiayu Liu, Limin Lin, Li Li, Donglin Cao, Qing Li & Zhong Wang. (2018) Single domain based bispecific antibody, Muc1-Bi-1, and its humanized form, Muc1-Bi-2, induce potent cancer cell killing in muc1 positive tumor cells. PLOS ONE 13:1, pages e0191024.
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Chien-Hsing Chang, Yang Wang, Rongxiu Li, Diane L. Rossi, Donglin Liu, Edmund A. Rossi, Thomas M. Cardillo & David M. Goldenberg. (2017) Combination Therapy with Bispecific Antibodies and PD-1 Blockade Enhances the Antitumor Potency of T Cells. Cancer Research 77:19, pages 5384-5394.
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Hong Wu, Li Yao, Lin Chou, Jin‑Hua Yang, Yun‑Xiu Zhang, Xiao‑Li Li & Bo‑Er Shan. (2016) Construction and functional analysis of an anti-human cervical carcinoma/anti-human CD3 single-chain bispecific antibody. Molecular Medicine Reports.
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Joanie Del Bano, Patrick Chames, Daniel Baty & Brigitte Kerfelec. (2015) Taking up Cancer Immunotherapy Challenges: Bispecific Antibodies, the Path Forward?. Antibodies 5:1, pages 1.
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Natalia Nuñez-Prado, Marta Compte, Seandean Harwood, Ana Álvarez-Méndez, Simon Lykkemark, Laura Sanz & Luis Álvarez-Vallina. (2015) The coming of age of engineered multivalent antibodies. Drug Discovery Today 20:5, pages 588-594.
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Alison J. Smith. (2015) New Horizons in Therapeutic Antibody Discovery: Opportunities and Challenges versus Small-Molecule Therapeutics. SLAS Discovery 20:4, pages 437-453.
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Edmund A. Rossi, Diane L. Rossi, Thomas M. Cardillo, Chien-Hsing Chang & David M. Goldenberg. (2014) Redirected T-Cell Killing of Solid Cancers Targeted with an Anti-CD3/Trop-2–Bispecific Antibody Is Enhanced in Combination with Interferon-α. Molecular Cancer Therapeutics 13:10, pages 2341-2351.
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