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The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines

Kaja Lund Affitech Research AS; Oslo, Norway; Cancer Stem Cell Innovation Center (SFI-CAST); Oslo University Hospital; Oslo, Norway; Section for Cellular and Genetic Therapy; Institute of Microbiology; Oslo University Hospital; Oslo, NorwayCorrespondence[email protected]

Monica Bostad Cancer Stem Cell Innovation Center (SFI-CAST); Oslo University Hospital; Oslo, Norway; Department of Radiation Biology; Institute for Cancer Research; Norwegian Radium Hospital; Oslo University Hospital; Oslo, Norway

Ellen Skarpen Confocal Microscopy Core Facility; Department of Biochemistry; Institute for Cancer Research; Norwegian Radium Hospital; Oslo University Hospital; Oslo, Norway

Michael Braunagel Affitech Research AS; Oslo, Norway

Sergej Kiprijanov Affitech Research AS; Oslo, Norway

Stefan Krauss Cancer Stem Cell Innovation Center (SFI-CAST); Oslo University Hospital; Oslo, Norway; Section for Cellular and Genetic Therapy; Institute of Microbiology; Oslo University Hospital; Oslo, Norway

Alex Duncan Affitech Research AS; Oslo, Norway

Anders Høgset Cancer Stem Cell Innovation Center (SFI-CAST); Oslo University Hospital; Oslo, Norway; PCI Biotech AS; Lysaker, Norway

Pål K. Selbo Cancer Stem Cell Innovation Center (SFI-CAST); Oslo University Hospital; Oslo, Norway; Department of Radiation Biology; Institute for Cancer Research; Norwegian Radium Hospital; Oslo University Hospital; Oslo, Norway; PCI Biotech AS; Lysaker, NorwayCorrespondence[email protected]

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Pages 1038-1050 | Received 09 Jan 2014, Accepted 13 Feb 2014, Published online: 18 Feb 2014

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https://doi.org/10.4161/mabs.28207
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Paula Enzian & Ramtin Rahmanzadeh. (2023) Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer. Pharmaceutics 15:8, pages 2040.
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Leonardo R. Ancheta, Patrick A. Shramm, Raschel Bouajram, Denise Higgins & Douglas A. Lappi. (2023) Streptavidin-Saporin: Converting Biotinylated Materials into Targeted Toxins. Toxins 15:3, pages 181.
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Andrea Mussini, Eleonora Uriati, Paolo Bianchini, Alberto Diaspro, Luigi Cavanna, Stefania Abbruzzetti & Cristiano Viappiani. (2022) Targeted photoimmunotherapy for cancer. Biomolecular Concepts 13:1, pages 126-147.
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Laura Sanz, Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Javier Lacadena & Alberto Anel. (2021) Antibody-Based Immunotoxins for Colorectal Cancer Therapy. Biomedicines 9:11, pages 1729.
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Yuyu Zhao, Jiajun Xu, Van Minh Le, Qianyi Gong, Shaoyu Li, Feng Gao, Lei Ni, Jianwen Liu & Xin Liang. (2019) EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer. Molecular Pharmaceutics 16:11, pages 4696-4710.
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Zhijian Luo, Mingxing Li, Meiling Zhou, Huayun Li, Youyou Chen, Xiaoqun Ren & Yan Dai. (2019) O2-evolving and ROS-activable nanoparticles for treatment of multi-drug resistant Cancer by combination of photodynamic therapy and chemotherapy. Nanomedicine: Nanotechnology, Biology and Medicine 19, pages 49-57.
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Prasanna Kumar Athyala, Srujana Chitipothu, Jagat Rakesh Kanwar, Subramanian Krishnakumar & Janakiraman Narayanan. (2018) Synthesis of saporin–antibody conjugates for targeting EpCAM positive tumour cells. IET Nanobiotechnology 13:1, pages 90-99.
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Sagar J. Pathak, James L. Mueller, Kevin Okamoto, Barun Das, Jozef Hertecant, Lynn Greenhalgh, Trevor Cole, Vered Pinsk, Baruch Yerushalmi, Odul E. Gurkan, Michael Yourshaw, Erick Hernandez, Sandy Oesterreicher, Sandhia Naik, Ian R. Sanderson, Irene Axelsson, Daniel Agardh, C. Richard Boland, Martin G. Martin, Christopher D. Putnam & Mamata Sivagnanam. (2019) EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome . Human Mutation 40:2, pages 142-161.
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Jana Ylva Tretter, Kenji Schorpp, Elke Luxenburger, Johannes Trambauer, Harald Steiner, Kamyar Hadian, Olivier Gires & Dierk Niessing. (2018) A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor. Journal of Biological Chemistry 293:23, pages 8994-9005.
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M. S. Eng, J. Kaur, L. Prasmickaite, B. Ø. Engesæter, A. Weyergang, E. Skarpen, K. Berg, M. G. Rosenblum, G. M. Mælandsmo, A. Høgset, S. Ferrone & P. K. Selbo. (2020) Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins. Photochemical & Photobiological Sciences 17:5, pages 539-551.
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Francesco Giansanti, David Flavell, Francesco Angelucci, Maria Fabbrini & Rodolfo Ippoliti. (2018) Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins. Toxins 10:2, pages 82.
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Joanna Macdonald, Justin Henri, Kislay Roy, Emma Hays, Michelle Bauer, Rakesh Veedu, Normand Pouliot & Sarah Shigdar. (2018) EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs. Cancers 10:1, pages 19.
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Peyman Ranji, Tayyebali Salmani Kesejini, Sara Saeedikhoo & Ali Mohammad Alizadeh. (2016) Targeting cancer stem cell-specific markers and/or associated signaling pathways for overcoming cancer drug resistance. Tumor Biology 37:10, pages 13059-13075.
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Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster & Colin Hopper. (2016) Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial. The Lancet Oncology 17:9, pages 1217-1229.
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Hendrik Fuchs, Alexander Weng & Roger Gilabert-Oriol. (2016) Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers. Toxins 8:7, pages 200.
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Alejandra Martinez de Pinillos Bayona, Caroline M. Moore, Marilena Loizidou, Alexander J. MacRobert & Josephine H. Woodhams. (2016) Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. International Journal of Cancer 138:5, pages 1049-1057.
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Pål Kristian Selbo, Monica Bostad, Cathrine Elisabeth Olsen, Victoria Tudor Edwards, Anders Høgset, Anette Weyergang & Kristian Berg. (2015) Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics. Photochemical & Photobiological Sciences 14:8, pages 1433-1450.
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Monica Bostad, Cathrine Elisabeth Olsen, Qian Peng, Kristian Berg, Anders Høgset & Pål Kristian Selbo. (2015) Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133–saporin by photochemical internalization — A minimally invasive cancer stem cell-targeting strategy. Journal of Controlled Release 206, pages 37-48.
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Jiujiao Gao, Qiu Yan, Jiao Wang, Shuai Liu & Xuesong Yang. (2015) Epithelial-to-Mesenchymal Transition Induced by TGF-?1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells. Journal of Cellular Physiology 230:4, pages 775-782.
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Jiujiao Gao, Qiu Yan, Shuai Liu & Xuesong Yang. (2014) Knockdown of EpCAM Enhances the Chemosensitivity of Breast Cancer Cells to 5-fluorouracil by Downregulating the Antiapoptotic Factor Bcl-2. PLoS ONE 9:7, pages e102590.
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The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines

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The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines

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