mAbs, Volume 6, Issue 4 (2014)

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mAbs, Volume 6, Issue 4 (2014)

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Editor's Corner

Editorial
Antibodies to watch in 2014
Mid-year update
Janice M Reichert
Pages: 799-802
Published online: 19 May 2014
AbstractforAntibodies to watch in 2014 | Full Text | References | PDF (198.4 KB)
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Editorial

Editorial
MAbImprove
A French “Laboratoire d’excellence” (LabEx) dedicated to therapeutic antibodies
André Pèlegrin, Arnaud Daguet & Hervé Watier
Pages: 803-804
Published online: 16 May 2014
CitationforMAbImprove | Full Text | References | PDF (142.4 KB)
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Meeting Report

Meeting Report
Antibody biosimilars: Fears or opportunities?
First LabEx MAbImprove industrial workshop, May 28, 2013; Tours, France
Audrey Guillon-Munos, Arnaud Daguet & Hervé Watier
Pages: 805-809
Published online: 08 Apr 2014
AbstractforAntibody biosimilars: Fears or opportunities? | Full Text | References | PDF (177.4 KB)
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Book Review

Therapeutic Fc-Fusion Proteins
Edited by Steven M Chamow, Thomas Ryll, Henry B Lowman and Deborah Farson
Michiel E Ultee
Pages: 810-811
Published online: 08 Apr 2014
CitationforTherapeutic Fc-Fusion Proteins | Full Text | References | PDF (132.9 KB)
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Perspective

Opening the door to innovation
Janine Schuurman, Yvo F Graus, Aran F Labrijn, Sigrid R Ruuls & Paul WHI Parren
Pages: 812-819
Published online: 24 Apr 2014
AbstractforOpening the door to innovation | Full Text | References | PDF (706.6 KB)
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Rituximab
How approval history is reflected by a corresponding patent filing strategy
Ulrich Storz
Pages: 820-837
Published online: 19 May 2014
AbstractforRituximab | Full Text | References | PDF (3.2 MB)
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Review

Review Article
Antibodies directed against receptor tyrosine kinases
Current and future strategies to fight cancer
Bénédicte FAUVEL & Aziz Yasri
Pages: 838-851
Published online: 14 May 2014
AbstractforAntibodies directed against receptor tyrosine kinases | Full Text | References | PDF (705.2 KB)
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Review Article
Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications
Mark Haverick, Selina Mengisen, Mohammed Shameem & Alexandre Ambrogelly
Pages: 852-858
Published online: 01 Apr 2014
AbstractforSeparation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications | Full Text | References | PDF (590.6 KB)
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Review Article
Comparative clinical pharmacokinetics of antibody-drug conjugates in first-in-human Phase 1 studies
Antoine Deslandes
Pages: 859-870
Published online: 25 Apr 2014
AbstractforComparative clinical pharmacokinetics of antibody-drug conjugates in first-in-human Phase 1 studies | Full Text | References | PDF (809.4 KB)
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Brief Report

Brief Report
Evaluation of cardiovascular parameters in cynomolgus monkeys following IV administration of LBR-101, a monoclonal antibody against calcitonin gene-related peptide
Sarah Walter, Abbas Alibhoy, Rafael Escandon & Marcelo E. Bigal
Pages: 871-878
Published online: 21 May 2014
AbstractforEvaluation of cardiovascular parameters in cynomolgus monkeys following IV administration of LBR-101, a monoclonal antibody against calcitonin gene-related peptide | Full Text | References | PDF (903.5 KB)
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Report

Article
A new tool for monoclonal antibody analysis
Application of IdeS proteolysis in IgG domain-specific characterization
Yan An, Ying Zhang, Hans-Martin Mueller, Mohammed Shameem & Xiaoyu Chen
Pages: 879-893
Published online: 07 Apr 2014
AbstractforA new tool for monoclonal antibody analysis | Full Text | References | PDF (2 MB)
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Article
Small scale affinity purification and high sensitivity reversed phase nanoLC-MS N-glycan characterization of mAbs and fusion proteins
Fabian Higel, Andreas Seidl, Uwe Demelbauer, Fritz Sörgel & Wolfgang Frieß
Pages: 894-903
Published online: 21 May 2014
AbstractforSmall scale affinity purification and high sensitivity reversed phase nanoLC-MS N-glycan characterization of mAbs and fusion proteins | Full Text | References | PDF (1.5 MB) | Supplemental
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Article
O-Glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins
Attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit
Chris Spahr, Stone D-H Shi & Hsieng S Lu
Pages: 904-914
Published online: 16 Apr 2014
AbstractforO-Glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins | Full Text | References | PDF (5.2 MB)
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Article
Highly parallel characterization of IgG Fc binding interactions
Austin W Boesch, Eric P Brown, Hao D Cheng, Maame Ofua Ofori, Erica Normandin, Peter A Nigrovic, Galit Alter & Margaret E Ackerman
Pages: 915-927
Published online: 16 Apr 2014
AbstractforHighly parallel characterization of IgG Fc binding interactions | Full Text | References | PDF (2.6 MB) | Supplemental
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Article
Characterization and screening of IgG binding to the neonatal Fc receptor
Tobias Neuber, Katrin Frese, Jan Jaehrling, Sebastian Jäger, Daniela Daubert, Karin Felderer, Mechthild Linnemann, Anne Höhne, Stefan Kaden, Johanna Kölln, Thomas Tiller, Bodo Brocks, Ralf Ostendorp & Stefan Pabst
Pages: 928-942
Published online: 07 Apr 2014
AbstractforCharacterization and screening of IgG binding to the neonatal Fc receptor | Full Text | References | PDF (3.4 MB) | Supplemental
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Article
Delivery of antibodies to the cytosol
Debunking the myths
Andrea LJ Marschall, Congcong Zhang, André Frenzel, Thomas Schirrmann, Michael Hust, Franck Perez & Stefan Dübel
Pages: 943-956
Published online: 21 May 2014
AbstractforDelivery of antibodies to the cytosol | Full Text | References | PDF (2.1 MB) | Supplemental
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Article
Non-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics
Non-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics
Gwendolyn M Wilmes, Kimberly L Carey, Stuart W Hicks, Hugh H Russell, Jesse A Stevenson, Paulina Kocjan, Stephen R Lutz, Rachel S Quesenberry, Sergey V Shulga-Morskoy, Megan E Lewis, Ethan Clark, Violetta Medik, Anthony B Cooper & Elizabeth E Reczek
Pages: 957-967
Published online: 23 Apr 2014
AbstractforNon-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics | Full Text | References | PDF (2.4 MB)
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Article
Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice
A novel approach to generate tumor cell specific human antibodies
Anja K Wege, Marcus Schmidt, Elke Ueberham, Marvin Ponnath, Olaf Ortmann, Gero Brockhoff & Jörg Lehmann
Pages: 968-977
Published online: 08 May 2014
AbstractforCo-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice | Full Text | References | PDF (2.1 MB) | Supplemental
  • 1904 Views
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Article
Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies
Wenyan Fu, Yuxiao Wang, Yunshan Zhang, Lijuan Xiong, Hiroaki Takeda, Li Ding, Qunfang Xu, Lidong He, Wenlong Tan, Augus N. Bethune & Lijun Zhou
Pages: 978-990
Published online: 16 Apr 2014
AbstractforInsights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies | Full Text | References | PDF (3.8 MB)
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Article
Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19
Dániel Szili, Marcell Cserhalmi, Zsuzsanna Bankó, György Nagy, David E Szymkowski & Gabriella Sármay
Pages: 991-999
Published online: 23 Apr 2014
AbstractforSuppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19 | Full Text | References | PDF (743 KB)
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Article
Antitumor effects of a monoclonal antibody to human CCR9 in leukemia cell xenografts
Sonia Chamorro, Maria Vela, Ana Franco-Villanueva, Laura Carramolino, Julio Gutiérrez, Lucio Gómez, María Lozano, Beatriz Salvador, Mónica García-Gallo, Carlos Martínez-A & Leonor Kremer
Pages: 1000-1012
Published online: 07 May 2014
AbstractforAntitumor effects of a monoclonal antibody to human CCR9 in leukemia cell xenografts | Full Text | References | PDF (13.1 MB) | Supplemental
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Article
Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor
Yaima Tundidor, Claudia Patricia García-Hernández, Amaury Pupo, Yanelys Cabrera Infante & Gertrudis Rojas
Pages: 1013-1025
Published online: 23 Apr 2014
AbstractforDelineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse
Marie Vincent, Géraldine Teppaz, Laurie Lajoie, Véronique Solé, Anne Bessard, Mike Maillasson, Séverine Loisel, David Béchard, Béatrice Clémenceau, Gilles Thibault, Laure Garrigue-Antar, Yannick Jacques & Agnès Quéméner
Pages: 1026-1037
Published online: 07 Apr 2014
AbstractforHighly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse | Full Text | References | PDF (2.1 MB) | Supplemental
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Article
The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
Kaja Lund, Monica Bostad, Ellen Skarpen, Michael Braunagel, Sergej Kiprijanov, Stefan Krauss, Alex Duncan, Anders Høgset & Pål K. Selbo
Pages: 1038-1050
Published online: 18 Feb 2014
AbstractforThe novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines | PDF (3 MB) | Supplemental
  • 1054 Views
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Article
ImmunoPET and biodistribution with human epidermal growth factor receptor 3 targeting antibody 89Zr-RG7116
Anton GT Terwisscha van Scheltinga, Marjolijn N Lub-de Hooge, Keelara Abiraj, Carolien P Schröder, Linda Pot, Birgit Bossenmaier, Marlene Thomas, Gabriele Hölzlwimmer, Thomas Friess, Jos GW Kosterink & Elisabeth GE de Vries
Pages: 1051-1058
Published online: 07 May 2014
AbstractforImmunoPET and biodistribution with human epidermal growth factor receptor 3 targeting antibody 89Zr-RG7116 | Full Text | References | PDF (3.1 MB)
  • 1504 Views
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Article
Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes
Sherry L La Porte, Charles Eigenbrot, Mark Ultsch, Wei-Hsien Ho, Davide Foletti, Alison Forgie, Kevin C Lindquist, David L Shelton & Jaume Pons
Pages: 1059-1068
Published online: 16 Apr 2014
AbstractforGeneration of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1593 Views
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Article
Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies
Yu-Cheng Su, Talal S Al-Qaisi, Hsin-Yi Tung, Tian-Lu Cheng, Kuo-Hsiang Chuang, Bing-Mae Chen & Steve R Roffler
Pages: 1069-1083
Published online: 14 May 2014
AbstractforMimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies | Full Text | References | PDF (3.7 MB) | Supplemental
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Article
Selection of a human butyrylcholinesterase-like antibody single-chain variable fragment resistant to AChE inhibitors from a phage library expressed in E. coli
Adriano Podestà, Serena Rossi, Ilaria Massarelli, Sara Carpi, Barbara Adinolfi, Stefano Fogli, Anna Maria Bianucci & Paola Nieri
Pages: 1084-1093
Published online: 27 Mar 2014
AbstractforSelection of a human butyrylcholinesterase-like antibody single-chain variable fragment resistant to AChE inhibitors from a phage library expressed in E. coli | Full Text | References | PDF (3.5 MB)
  • 840 Views
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Article
A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design
Jasmine P Davda, Michael G Dodds, Megan A Gibbs, Wendy Wisdom & John P Gibbs
Pages: 1094-1102
Published online: 16 May 2014
AbstractforA model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design | Full Text | References | PDF (871.1 KB)
  • 3914 Views
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Article
Characterization of a quantitative method to measure free proprotein convertase subtilisin/kexin type 9 in human serum
Alexander Colbert, Amber Umble-Romero, Samantha Prokop, Ren Xu, John P Gibbs & Susan Pederson
Pages: 1103-1113
Published online: 16 Apr 2014
AbstractforCharacterization of a quantitative method to measure free proprotein convertase subtilisin/kexin type 9 in human serum | Full Text | References | PDF (1.1 MB)
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