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FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen

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Pages 173-180 | Received 14 Jan 2011, Accepted 13 Dec 2010, Published online: 01 Mar 2011

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Yuan Wang, Zehua Tian, Diraviyam Thirumalai & Xiaoying Zhang. (2014) Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering. Journal of Drug Targeting 22:4, pages 269-278.
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Judit Cervenak, Márton Doleschall, Balázs Bender, Balázs Mayer, Zita Schneider, Zoltán Doleschall, Yaofeng Zhao, Zsuzsanna Bősze, Lennart Hammarström, Wolfgang Oster & Imre Kacskovics. (2013) NFκB induces overexpression of bovine FcRn. mAbs 5:6, pages 860-871.
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Timothy T. Kuo & Victoria G. Aveson. (2011) Neonatal Fc receptor and IgG-based therapeutics. mAbs 3:5, pages 422-430.
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Articles from other publishers (15)

Victoria P. Werth, Donna A. Culton, Josef S.S. Concha, James S. Graydon, Laurence J. Blumberg, Joyce Okawa, Michal Pyzik, Richard S. Blumberg & Russell P. HallIIIIII. (2021) Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus. Journal of Investigative Dermatology 141:12, pages 2858-2865.e4.
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Juliette Lamamy, Pierre Boulard, Guillaume Brachet, Sébastien Tourlet, Valérie Gouilleux-Gruart & Yanis Ramdani. (2021) “Ways in which the neonatal Fc-receptor is involved in autoimmunity”. Journal of Translational Autoimmunity 4, pages 100122.
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Bence Szikora, Anita Marx, Péter K. Jani, Orsolya Pipek, Viktor Müller, István Csabai & Imre Kacskovics. (2020) FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice. Frontiers in Immunology 11.
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Weihsu C. Chen & Christopher M. Murawsky. (2018) Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies. Frontiers in Immunology 9.
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Zhanna Shubin, Yutaka Tagaya & Bhawna Poonia. (2017) Functional polymorphisms in rhesus macaque FCGRT and β2-m. Immunogenetics 70:3, pages 179-183.
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Jinyue Guo, Fei Li, Shaoju Qian, Dingren Bi, Qigai He, Hui Jin, Rui Luo, Shaowen Li, Xianrong Meng & Zili Li. (2016) TGEV infection up-regulates FcRn expression via activation of NF-κB signaling. Scientific Reports 6:1.
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Xuemei Jiang, Jianjun Hu, Diraviyam Thirumalai & Xiaoying Zhang. (2016) Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor. Frontiers in Immunology 7.
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Judit Cervenak, Roland Kurrle & Imre Kacskovics. (2015) Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptor as a result of augmented humoral immunity. Immunological Reviews 268:1, pages 269-287.
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Nigel M. Stapleton, Helga K. Einarsd?ttir, Annette M. Stemerding & Gestur Vidarsson. (2015) The multiple facets of FcRn in immunity. Immunological Reviews 268:1, pages 253-268.
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Zita Schneider, Péter Károly Jani, Bence Szikora, Attila Végh, Dorottya Kövesdi, Attila Iliás, Judit Cervenak, Péter Balogh, István Kurucz & Imre Kacskovics. (2015) Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen. Frontiers in Immunology 6.
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Kristi Baker, Timo Rath, Michal Pyzik & Richard S. Blumberg. (2014) The Role of FcRn in Antigen Presentation. Frontiers in Immunology 5.
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Mária Baranyi, Judit Cervenak, Balázs Bender & Imre Kacskovics. (2013) Transgenic Rabbits That Overexpress the Neonatal Fc Receptor (FcRn) Generate Higher Quantities and Improved Qualities of Anti-Thymocyte Globulin (ATG). PLoS ONE 8:10, pages e76839.
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V. Duranthon, N. Beaujean, M. Brunner, K. E. Odening, A. Navarrete Santos, I. Kacskovics, L. Hiripi, E. J. Weinstein & Z. Bosze. (2012) On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools. Transgenic Research 21:4, pages 699-713.
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Attila V?gh, Anita Farkas, Dorottya K?vesdi, Kriszti?n Papp, Judit Cervenak, Zita Schneider, Bal?zs Bender, L?szl? Hiripi, Gl?ria L?szl?J?zsef Prechl, J?nos Matk?Imre Kacskovics. (2012) FcRn Overexpression in Transgenic Mice Results in Augmented APC Activity and Robust Immune Response with Increased Diversity of Induced Antibodies. PLoS ONE 7:4, pages e36286.
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Ana Paula Catunda Lemos, Judit Cervenak, Bal?zs Bender, Orsolya Ivett Hoffmann, M?ria Baranyi, Andrea Kerekes, Anita Farkas, Zsuzsanna B?sze, L?szl? Hiripi & Imre Kacskovics. (2012) Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn. PLoS ONE 7:1, pages e28869.
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