Citations (34)
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Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano & Yiqing Feng. (2023) Impact of IgG subclass on monoclonal antibody developability. mAbs 15:1.
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Hok Seon Kim, Ingrid Kim, Linda Zheng, Jean-Michel Vernes, Y. Gloria Meng & Christoph Spiess. (2016) Evading pre-existing anti-hinge antibody binding by hinge engineering. mAbs 8:8, pages 1536-1547.
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Michelle Kinder, Allison R Greenplate, William R Strohl, Robert E Jordan & Randall J Brezski. (2015) An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions. mAbs 7:3, pages 494-504.
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Randall J Brezski, Michelle Kinder, Katharine D Grugan, Keri L Soring, Jill Carton, Allison R Greenplate, Theodore Petley, Dorie Capaldi, Kerry Brosnan, Eva Emmell, Sharon Watson & Robert E Jordan. (2014) A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo. mAbs 6:5, pages 1265-1273.
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Articles from other publishers (30)
Andrea Engelmaier, Harald A Butterweck & Alfred Weber. (2023) Stability assessment of anti-bacterial antibodies in immunoglobulin G-depleted serum with validated immunoassays. Immunotherapy 15:17, pages 1459-1476.
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Timothée Blin, Christelle Parent, Gabrielle Pichon, Antoine Guillon, Youenn Jouan, Hassan Allouchi, Nicolas Aubrey, Fanny Boursin, Roxane Domain, Baris Korkmaz, Thomas Sécher & Nathalie Heuzé-Vourc'h. (2023) The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies. European Journal of Pharmaceutics and Biopharmaceutics.
Crossref
Crossref
Ahlam N. QerqezRui P. Silva & Jennifer A. Maynard. (2023) Outsmarting Pathogens with Antibody Engineering. Annual Review of Chemical and Biomolecular Engineering 14:1, pages 217-241.
Crossref
Crossref
Matthew G. Romei, Brandon Leonard, Ingrid Kim, Hok Seon Kim & Greg A. Lazar. (2023) Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets. Journal of Biological Chemistry 299:5, pages 104685.
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Crossref
Dileep Francis, Anusha Bhairaddy, Atheene Joy, Gopika Veeramanickathadathil Hari & Ashik Francis. 2023. Secretory Proteins. Secretory Proteins
271
350
.
Seiji Saito, Hiroshi Namisaki, Keiko Hiraishi, Nobuaki Takahashi & Shigeru Iida. (2020) Engineering a human IgG2 antibody stable at low pH. Protein Science 29:5, pages 1186-1195.
Crossref
Crossref
Wei-Li Ling, Wai-Heng Lua & Samuel Ken-En Gan. (2020) Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles. Antibody Therapeutics 3:2, pages 71-79.
Crossref
Crossref
Brigida Barberio, Renata D’Incà, Sonia Facchin, Marianna Dalla Gasperina, Cedric Arsenè Fohom Tagne, Romilda Cardin, Matteo Ghisa, Greta Lorenzon, Carla Marinelli, Edoardo Vincenzo Savarino & Fabiana Zingone. (2020) Matrix Metalloproteinase 3 Predicts Therapeutic Response in Inflammatory Bowel Disease Patients Treated With Infliximab. Inflammatory Bowel Diseases 26:5, pages 756-763.
Crossref
Crossref
Tae Hyun Kang & Sang Taek Jung. (2020) Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer. Biomolecules 10:3, pages 382.
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Quentin Deveuve, Laurie Lajoie, Benjamin Barrault & Gilles Thibault. (2020) The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass. Frontiers in Immunology 11.
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Mark L. Chiu, Dennis R. Goulet, Alexey Teplyakov & Gary L. Gilliland. (2019) Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies 8:4, pages 55.
Crossref
Crossref
Quentin Deveuve, Valérie Gouilleux-Gruart, Gilles Thibault & Laurie Lajoie. (2020) La région charnière des anticorps thérapeutiques. médecine/sciences 35:12, pages 1098-1105.
Crossref
Crossref
Gar Kay Hui, Antoni D. Gardener, Halima Begum, Charles Eldrid, Konstantinos Thalassinos, Jayesh Gor & Stephen J. Perkins. (2019) The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions. Journal of Biological Chemistry 294:28, pages 10789-10806.
Crossref
Crossref
Wei Zhou, Shanshan Lin, Rongying Chen, Jun Liu & Yali Li. (2018) Characterization of antibody-C1q interactions by Biolayer Interferometry. Analytical Biochemistry 549, pages 143-148.
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Crossref
Randi B. Gombos, Ana Gonzalez, Mariana Manrique, Dhan Chand, David Savitsky, Benjamin Morin, Ekaterina Breous-Nystrom, Christopher Dupont, Rebecca A. Ward, Cornelia Mundt, Benjamin Duckless, Hao Tang, Mark A. Findeis, Andrea Schuster, Jeremy D. Waight, Dennis Underwood, Christopher Clarke, Gerd Ritter, Taha Merghoub, David Schaer, Jedd D. Wolchok, Marc van Dijk, Jennifer S. Buell, Jean-Marie Cuillerot, Robert Stein, Elise E. Drouin & Nicholas S. Wilson. (2018) Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. PLOS ONE 13:4, pages e0191926.
Crossref
Crossref
Tao Huang, Mary Mathieu, Sophia Lee, Xinhua Wang, Yee Seir Kee, Jack J. BeversIIIIII, Claudio Ciferri, Alberto Estavez, Manda Wong, Nancy Y. Chiang, Gerald Nakamura & Randall J. Brezski. (2018) Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells. Journal of Biological Chemistry 293:3, pages 906-919.
Crossref
Crossref
Willem J. J. Falkenburg, Dirkjan van Schaardenburg, Pleuni Ooijevaar-de Heer, Michel W. P. Tsang-A-Sjoe, Irene E. M. Bultink, Alexandre E. Voskuyl, Arthur E. H. Bentlage, Gestur Vidarsson, Gertjan Wolbink & Theo Rispens. (2017) Anti-Hinge Antibodies Recognize IgG Subclass– and Protease-Restricted Neoepitopes. The Journal of Immunology 198:1, pages 82-93.
Crossref
Crossref
Randall J Brezski & George Georgiou. (2016) Immunoglobulin isotype knowledge and application to Fc engineering. Current Opinion in Immunology 40, pages 62-69.
Crossref
Crossref
Robert E. Jordan, Jeffrey Fernandez, Randall J. Brezski, Allison R. Greenplate, David M. Knight, T. Shantha Raju & A. Simon Lynch. (2016) A peptide immunization approach to counteract a Staphylococcus aureus protease defense against host immunity. Immunology Letters 172, pages 29-39.
Crossref
Crossref
Vipul Yadav, Felipe Varum, Roberto Bravo, Esther Furrer & Abdul W. Basit. (2016) Gastrointestinal stability of therapeutic anti-TNF α IgG1 monoclonal antibodies. International Journal of Pharmaceutics 502:1-2, pages 181-187.
Crossref
Crossref
Ningyan Zhang, Hui Deng, Xuejun Fan, Anneliese Gonzalez, Songlin Zhang, Randall J. Brezski, Byung-Kwon Choi, Michael Rycyzyn, William Strohl, Robert Jordan & Zhiqiang An. (2015) Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity. Clinical Cancer Research 21:23, pages 5380-5390.
Crossref
Crossref
Paolo Biancheri, Randall J. Brezski, Antonio Di Sabatino, Allison R. Greenplate, Keri L. Soring, Gino R. Corazza, Klaartje B. Kok, Laura Rovedatti, Anna Vossenk?mper, Nadja Ahmad, Susanne A. Snoek, Severine Vermeire, Paul Rutgeerts, Robert E. Jordan & Thomas T. MacDonald. (2015) Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease. Gastroenterology 149:6, pages 1564-1574.e3.
Crossref
Crossref
Randall J. Brezski. 2015. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies
125
146
.
Lotte A. van de Stadt, Henk de Vrieze, Ninotska I. L. Derksen, Mieke Brouwer, Diana Wouters, Dirkjan van Schaardenburg, Gertjan Wolbink & Theo Rispens. (2014) Antibodies to IgG4 Hinge Can Be Found in Rheumatoid Arthritis Patients During All Stages of Disease and May Exacerbate Chronic Antibody-Mediated Inflammation. Arthritis & Rheumatology 66:5, pages 1133-1140.
Crossref
Crossref
Víctor Pérez Medina Martínez, Mario E. Abad-Javier, Alexis J. Romero-Díaz, Francisco Villaseñor-Ortega, Néstor O. Pérez, Luis F. Flores-Ortiz & Emilio Medina-Rivero. (2014) Comparability of a Three-Dimensional Structure in Biopharmaceuticals Using Spectroscopic Methods. Journal of Analytical Methods in Chemistry 2014, pages 1-11.
Crossref
Crossref
Rens Braster, Tom O’Toole & Marjolein van Egmond. (2014) Myeloid cells as effector cells for monoclonal antibody therapy of cancer. Methods 65:1, pages 28-37.
Crossref
Crossref
Michelle Kinder, Allison R. Greenplate, Katharine D. Grugan, Keri L. Soring, Katharine A. Heeringa, Stephen G. McCarthy, Gregory Bannish, Meredith Perpetua, Frank Lynch, Robert E. Jordan, William R. Strohl & Randall J. Brezski. (2013) Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions. Journal of Biological Chemistry 288:43, pages 30843-30854.
Crossref
Crossref
Xunlong Shi, Jianjun Yang, Haiyan Zhu, Li Ye, Meiqing Feng, Jiyang Li, Hai Huang, Qun Tao, Dan Ye, Lee-Hwei K. Sun, Bill N. C. Sun, Cecily R. Y. Sun, Guizhen Han, Yuanyuan Liu, Minghui Yao, Pei Zhou & Dianwen Ju. (2013) Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO-Fc Fusion Protein In Vivo. PLoS ONE 8:8, pages e72673.
Crossref
Crossref
A. Guentsch, C. Hirsch, W. Pfister, B. Vincents, M. Abrahamson, A. Sroka, J. Potempa & S. Eick. (2012)
Cleavage of IgG1 in gingival crevicular fluid is associated with the presence of
P
orphyromonas gingivalis
. Journal of Periodontal Research 48:4, pages 458-465.
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Katharine D. Grugan, Francis L. McCabe, Michelle Kinder, Allison R. Greenplate, Benjamin C. Harman, Jason E. Ekert, Nico van Rooijen, G. Mark Anderson, Jeffrey A. Nemeth, William R. Strohl, Robert E. Jordan & Randall J. Brezski. (2012) Tumor-Associated Macrophages Promote Invasion while Retaining Fc-Dependent Anti-Tumor Function. The Journal of Immunology 189:11, pages 5457-5466.
Crossref
Crossref