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OncoImmunology Volume 1, 2012 - Issue 7
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Original Research

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice

Mariana Malvicini Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina
,
Laura Alaniz Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina; CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas); Buenos Aires, Argentina
,
Juan Bayo Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina
,
Mariana Garcia Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina; CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas); Buenos Aires, Argentina
,
Flavia Piccioni Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina
,
Esteban Fiore Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina
,
Catalina Atorrasagasti Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina
,
Jorge B. Aquino Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina; CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas); Buenos Aires, Argentina
,
Pablo Matar Institute of Experimental Genetics; School of Medical Sciences; National University of Rosario; Rosario, Argentina; CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas); Buenos Aires, Argentina
&
Guillermo Mazzolini Gene Therapy Laboratory; Liver Unit; School of Medicine; Austral University; Buenos Aires, Argentina; CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas); Buenos Aires, ArgentinaCorrespondence[email protected]
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Pages 1038-1047 | Received 10 Apr 2012, Accepted 08 May 2012, Published online: 01 Oct 2012

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Jonathan Pol, Aitziber Buqué, Fernando Aranda, Norma Bloy, Isabelle Cremer, Alexander Eggermont, Philippe Erbs, Jitka Fucikova, Jérôme Galon, Jean-Marc Limacher, Xavier Preville, Catherine Sautès-Fridman, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Oncolytic viruses and cancer therapy. OncoImmunology 5:2.
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Jonathan Pol, Norma Bloy, Florine Obrist, Alexander Eggermont, Jérôme Galon, Isabelle Cremer, Philippe Erbs, Jean-Marc Limacher, Xavier Preville, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2014) Trial Watch:. OncoImmunology 3:6.
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Gwenola Manic, Florine Obrist, Guido Kroemer, Ilio Vitale & Lorenzo Galluzzi. (2014) Chloroquine and hydroxychloroquine for cancer therapy. Molecular & Cellular Oncology 1:1.
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Erika Vacchelli, Nicole Prada, Oliver Kepp & Lorenzo Galluzzi. (2013) Current trends of anticancer immunochemotherapy. OncoImmunology 2:6.
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Erika Vacchelli, Laura Senovilla, Alexander Eggermont, Wolf Hervé Fridman, Jérôme Galon, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2013) Trial watch. OncoImmunology 2:3.
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Mariana Malvicini, Flavia Piccioni, Juan Bayo, Esteban Fiore, Catalina Atorrasagasti, Laura Alaniz, Mariana Garcia, Jorge B. Aquino, Manuel Gidekel, Pablo Matar & Guillermo Mazzolini. (2012) Chemoimmunotherapy for advanced gastrointestinal carcinomas: A successful combination of gene therapy and cyclophosphamide. OncoImmunology 1:9, pages 1626-1628.
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Articles from other publishers (14)

Sonia Aristin Revilla, Onno Kranenburg & Paul J. Coffer. (2022) Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting. Frontiers in Immunology 13.
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Pavlina Spiliopoulou, Samantha Hinsley, Iain A McNeish, Patricia Roxburgh & Ros Glasspool. (2021) Metronomic oral cyclophosphamide in relapsed ovarian cancer. International Journal of Gynecologic Cancer 31:7, pages 1037-1044.
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Hui Zhong, Yifan Lai, Rui Zhang, Abdelkader Daoud, Qingyuan Feng, Jia Zhou & Jing Shang. (2020) Low Dose Cyclophosphamide Modulates Tumor Microenvironment by TGF-β Signaling Pathway. International Journal of Molecular Sciences 21:3, pages 957.
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Raja Pramanik & Sameer Bakhshi. (2019) Metronomic therapy in pediatric oncology: A snapshot. Pediatric Blood & Cancer 66:9.
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Jiemiao Hu, Chuang Sun, Chantale Bernatchez, Xueqing Xia, Patrick Hwu, Gianpietro Dotti & Shulin Li. (2018) T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors. Clinical Cancer Research 24:12, pages 2920-2934.
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Junjie Wu & David J. Waxman. (2018) Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy. Cancer Letters 419, pages 210-221.
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Marie Jordan & David J. Waxman. (2016) CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model. Cancer Letters 373:1, pages 88-96.
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Ruben Hernandez-Alcoceba, Joanna Poutou, María Cristina Ballesteros-Briones & Cristian Smerdou. (2016) Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12 . Immunotherapy 8:2, pages 179-198.
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Witold Lasek & Radoslaw ZagozdzonWitold Lasek & Marek Jakóbisiak. 2016. Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology. Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology 21 41 .
E Peixoto, C Atorrasagasti, J B Aquino, R Militello, J Bayo, E Fiore, F Piccioni, E Salvatierra, L Alaniz, M G García, R Bataller, F Corrales, M Gidekel, O Podhajcer, M I Colombo & G Mazzolini. (2014) SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage. Gene Therapy 22:1, pages 9-19.
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Nicolas André, Manon Carré & Eddy Pasquier. (2014) Metronomics: towards personalized chemotherapy?. Nature Reviews Clinical Oncology 11:7, pages 413-431.
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José Manuel Bravo-San Pedro & Laura Senovilla. (2013) Immunostimulatory activity of lifespan-extending agents. Aging 5:11, pages 793-801.
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YONGBIN MOU, HAO XIE, XIAOFENG HUANG, WEI HAN, YANHONG NI, HANG SU, ZHIYONG WANG & QINGANG HU. (2013) Immunological suppression of head and neck carcinoma by dendritic cell tumor fusion vaccine. Oncology Letters 6:6, pages 1799-1803.
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Khursheed Anwer, F. Joseph Kelly, Christina Chu, Jason G. Fewell, Danny Lewis & Ronald D. Alvarez. (2013) Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer. Gynecologic Oncology 131:1, pages 169-173.
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