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Prion Volume 4, 2010 - Issue 4
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Commentary & View

Structural requirements for efficient prion protein conversion

Cofactors may promote a conversion-competent structure for PrPC

Andrew C. Gill Roslin InstituteCorrespondence[email protected]
,
Sonya Agarwal The Roslin Institute and R(D)SVS; University of Edinburgh; Easter Bush Veterinary Centre; Edinburgh UK
,
Teresa J.T. Pinheiro Department of Biological Sciences; University of Warwick; Coventry UK
&
James F. Graham The Roslin Institute and R(D)SVS; University of Edinburgh; Easter Bush Veterinary Centre; Edinburgh UK
Pages 235-243 | Received 08 Jul 2010, Accepted 20 Aug 2010, Published online: 01 Oct 2010

Citations (11)

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Eirini Kanata, Minas Arsenakis & Theodoros Sklaviadis. (2016) Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells. Prion 10:5, pages 391-408.
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Articles from other publishers (10)

Chafik Harrathi, Natalia Fernández-Borges, Hasier Eraña, Saioa R. Elezgarai, Vanessa Venegas, Jorge M. Charco & Joaquín Castilla. (2018) Insights into the Bidirectional Properties of the Sheep–Deer Prion Transmission Barrier. Molecular Neurobiology 56:8, pages 5287-5303.
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Andrew C. Gill & Andrew R. Castle. 2018. Human Prion Diseases. Human Prion Diseases 21 44 .
Alvin S. Das & Wen-Quan Zou. (2016) Prions: Beyond a Single Protein. Clinical Microbiology Reviews 29:3, pages 633-658.
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T R Doeppner, B Kaltwasser, J Schlechter, J Jaschke, E Kilic, M Bähr, D M Hermann & J Weise. (2015) Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition. Cell Death & Disease 6:12, pages e2024-e2024.
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Sonya Agarwal, Kristina Döring, Leszek A. Gierusz, Pooja Iyer, Fiona M. Lane, James F. Graham, Wilfred Goldmann, Teresa J. T. Pinheiro & Andrew C. Gill. (2015) Complex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein. Scientific Reports 5:1.
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Martin L. Daus, Katja Wagenführ, Achim Thomzig, Susann Boerner, Peter Hermann, Antje Hermelink, Michael Beekes & Peter Lasch. (2013) Infrared Microspectroscopy Detects Protein Misfolding Cyclic Amplification (PMCA)-induced Conformational Alterations in Hamster Scrapie Progeny Seeds. Journal of Biological Chemistry 288:49, pages 35068-35080.
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Mark A. Ritchie, Lawrence G. Hunt & Andrew C. Gill. (2013) Lysine hydroxylation and O-glycosylation in the globular, C-terminal region of mammalian-expressed, recombinant PrP. International Journal of Mass Spectrometry 345-347, pages 132-141.
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Leah M. Kyle, Theodore R. John, Hermann M. Schätzl & Randolph V. Lewis. (2013) Introducing a Rigid Loop Structure from Deer into Mouse Prion Protein Increases Its Propensity for Misfolding In Vitro. PLoS ONE 8:6, pages e66715.
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Z. Zhou & G. Xiao. (2013) Conformational conversion of prion protein in prion diseases. Acta Biochimica et Biophysica Sinica 45:6, pages 465-476.
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Justin R. Piro, Brent T. Harris & Surachai Supattapone. (2011) In Situ Photodegradation of Incorporated Polyanion Does Not Alter Prion Infectivity. PLoS Pathogens 7:2, pages e1002001.
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