3,775
Views
69
CrossRef citations to date
0
Altmetric
Research Paper

Diversity of human tRNA genes from the 1000-genomes project

, &
Pages 1853-1867 | Received 28 Oct 2013, Accepted 27 Nov 2013, Published online: 09 Dec 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ecaterina Cozma, Megha Rao, Madison Dusick, Julie Genereaux, Ricard A. Rodriguez-Mias, Judit Villén, Christopher J. Brandl & Matthew D. Berg. (2023) Anticodon sequence determines the impact of mistranslating tRNAAla variants. RNA Biology 20:1, pages 791-804.
Read now
Lieselotte Erber, Anne Hoffmann, Jörg Fallmann, Heike Betat, Peter F. Stadler & Mario Mörl. (2020) LOTTE-seq (Long hairpin oligonucleotide based tRNA high-throughput sequencing): specific selection of tRNAs with 3’-CCA end for high-throughput sequencing. RNA Biology 17:1, pages 23-32.
Read now
Matthew D. Berg, Daniel J. Giguere, Jacqueline S. Dron, Jeremy T. Lant, Julie Genereaux, Calwing Liao, Jian Wang, John F. Robinson, Gregory B. Gloor, Robert A. Hegele, Patrick O’Donoghue & Christopher J. Brandl. (2019) Targeted sequencing reveals expanded genetic diversity of human transfer RNAs. RNA Biology 16:11, pages 1574-1585.
Read now
Jeremy T. Lant, Matthew D. Berg, Daniel H. W. Sze, Kyle S. Hoffman, Ibukunoluwa C. Akinpelu, Matthew A. Turk, Ilka U. Heinemann, Martin L. Duennwald, Christopher J. Brandl & Patrick O'Donoghue. (2018) Visualizing tRNA-dependent mistranslation in human cells. RNA Biology 15:4-5, pages 567-575.
Read now

Articles from other publishers (65)

Alexandra M. Pinzaru & Sohail F. Tavazoie. (2023) Transfer RNAs as dynamic and critical regulators of cancer progression. Nature Reviews Cancer 23:11, pages 746-761.
Crossref
Eric B Rondeau, Kris A Christensen, Hollie A Johnson, Dionne Sakhrani, Carlo A Biagi, Mike Wetklo, Cody A Despins, Rosalind A Leggatt, David R Minkley, Ruth E Withler, Terry D Beacham, Ben F Koop & Robert H Devlin. (2023) Insights from a chum salmon ( Oncorhynchus keta ) genome assembly regarding whole-genome duplication and nucleotide variation influencing gene function . G3: Genes, Genomes, Genetics 13:8.
Crossref
D. Joe Millward. (2023) Post-natal muscle growth and protein turnover: a narrative review of current understanding. Nutrition Research Reviews, pages 1-28.
Crossref
Marcos Davyt, Nikhil Bharti & Zoya Ignatova. (2023) Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases. Journal of Biological Chemistry, pages 105089.
Crossref
Daixi Ren, Yongzhen Mo, Mei Yang, Dan Wang, Yumin Wang, Qijia Yan, Can Guo, Wei Xiong, Fuyan Wang & Zhaoyang Zeng. (2023) Emerging roles of tRNA in cancer. Cancer Letters 563, pages 216170.
Crossref
Laetitia A. Hughes, Danielle L. Rudler, Stefan J. Siira, Tim McCubbin, Samuel A. Raven, Jasmin M. Browne, Judith A. Ermer, Jeanette Rientjes, Jennifer Rodger, Esteban Marcellin, Oliver Rackham & Aleksandra Filipovska. (2023) Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation. Nature Communications 14:1.
Crossref
Xiaofeng Zhang, Fenghua Yang, Xiechao Zhan, Tong Bian, Zhihan Xing, Yichen Lu & Yigong Shi. (2023) Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Molecular Cell 83:8, pages 1328-1339.e4.
Crossref
Yuri Pekarsky, Veronica Balatti & Carlo M. Croce. (2022) tRNA-derived fragments (tRFs) in cancer. Journal of Cell Communication and Signaling 17:1, pages 47-54.
Crossref
Farah Hasan, Jeremy T. Lant & Patrick O'Donoghue. (2023) Perseverance of protein homeostasis despite mistranslation of glycine codons with alanine. Philosophical Transactions of the Royal Society B: Biological Sciences 378:1871.
Crossref
Jeremy T. Lant, Farah Hasan, Julia Briggs, Ilka U. Heinemann & Patrick O’Donoghue. (2023) Genetic Interaction of tRNA-Dependent Mistranslation with Fused in Sarcoma Protein Aggregates. Genes 14:2, pages 518.
Crossref
Jianglin Zhou, Yaling Xing, Zhe Zhou & Shengqi Wang. (2023) A comprehensive analysis of Usutu virus (USUV) genomes revealed lineage-specific codon usage patterns and host adaptations. Frontiers in Microbiology 13.
Crossref
Suja George, Mohammed Rafi, Maitha Aldarmaki, Mohamed ElSiddig, Mariam Al Nuaimi & Khaled M. A. Amiri. (2022) tRNA derived small RNAs—Small players with big roles. Frontiers in Genetics 13.
Crossref
Caroline Jane Ross & Igor Ulitsky. (2022) Discovering functional motifs in long noncoding RNAs . WIREs RNA 13:4.
Crossref
Eric Westhof, Bryan Thornlow, Patricia P Chan & Todd M Lowe. (2022) Eukaryotic tRNA sequences present conserved and amino acid-specific structural signatures. Nucleic Acids Research 50:7, pages 4100-4112.
Crossref
Nur Canpolat, Dingxiao Liu, Emine Atayar, Seha Saygili, Nazli Sila Kara, Trudi A. Westfall, Qiong Ding, Bartley J. Brown, Terry A. Braun, Diane Slusarski, Kader Karli Oguz, Yasemin Ozluk, Beyhan Tuysuz, Tugba Tastemel Ozturk, Lale Sever, Osman Ugur Sezerman, Rezan Topaloglu, Salim Caliskan, Massimo Attanasio & Fatih Ozaltin. (2022) A splice site mutation in the TSEN2 causes a new syndrome with craniofacial and central nervous system malformations, and atypical hemolytic uremic syndrome . Clinical Genetics.
Crossref
Jeremy T Lant, Rashmi Kiri, Martin L Duennwald & Patrick O’Donoghue. (2021) Formation and persistence of polyglutamine aggregates in mistranslating cells. Nucleic Acids Research 49:20, pages 11883-11899.
Crossref
Samoil Sekulovski, Pascal Devant, Silvia Panizza, Tasos Gogakos, Anda Pitiriciu, Katharina Heitmeier, Ewan Phillip Ramsay, Marie Barth, Carla Schmidt, Thomas Tuschl, Frank Baas, Stefan Weitzer, Javier Martinez & Simon Trowitzsch. (2021) Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia. Nature Communications 12:1.
Crossref
Nafisa Nazipova. (2021) Variety of Non-Coding RNAs in Eukaryotic Genomes. Mathematical Biology and Bioinformatics 16:2, pages 256-298.
Crossref
Petra Beznosková, Laure Bidou, Olivier Namy & Leoš Shivaya Valášek. (2021) Increased expression of tryptophan and tyrosine tRNAs elevates stop codon readthrough of reporter systems in human cell lines. Nucleic Acids Research 49:9, pages 5202-5215.
Crossref
Richard J. Acton, Wei Yuan, Fei Gao, Yudong Xia, Emma Bourne, Eva Wozniak, Jordana Bell, Karen Lillycrop, Jun Wang, Elaine Dennison, Nicholas C. Harvey, Charles A. Mein, Tim D. Spector, Pirro G. Hysi, Cyrus Cooper & Christopher G. Bell. (2021) The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation. Nature Communications 12:1.
Crossref
Doowon Huh, Maria C Passarelli, Jenny Gao, Shahnoza N Dusmatova, Clara Goin, Lisa Fish, Alexandra M Pinzaru, Henrik Molina, Zhiji Ren, Elizabeth A McMillan, Hosseinali Asgharian, Hani Goodarzi & Sohail F Tavazoie. (2020) A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression. The EMBO Journal 40:2.
Crossref
Zhangli SuBriana WilsonPankaj KumarAnindya Dutta. (2020) Noncanonical Roles of tRNAs: tRNA Fragments and Beyond. Annual Review of Genetics 54:1, pages 47-69.
Crossref
Xiwei Sun, Juze Yang, Mengqian Yu, Dongxia Yao, Liyuan Zhou, Xufan Li, Qiongzi Qiu, Weiqiang Lin, Bingjian Lu, Enguo Chen, Ping Wang, Wantao Chen, Sifeng Tao, Haiming Xu, Anna Williams, Yong Liu, Xiaoqing Pan, Allen W CowleyJrJr, Weiguo Lu, Mingyu Liang, Pengyuan Liu & Yan Lu. (2020) Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers. NAR Cancer 2:4.
Crossref
Mridu Kapur, Archan Ganguly, Gabor Nagy, Scott I. Adamson, Jeffrey H. Chuang, Wayne N. Frankel & Susan L. Ackerman. (2020) Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility. Neuron 108:1, pages 193-208.e9.
Crossref
Kevin M. Cheung, John M. Abendroth, Nako Nakatsuka, Bowen Zhu, Yang Yang, Anne M. Andrews & Paul S. Weiss. (2020) Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors. Nano Letters 20:8, pages 5982-5990.
Crossref
Bella Koltun, Sivan Ironi, Noga Gershoni-Emek, Iliana Barrera, Mohammad Hleihil, Siddharth Nanguneri, Ranjan Sasmal, Sarit S Agasti, Deepak Nair & Kobi Rosenblum. (2020) Measuring mRNA translation in neuronal processes and somata by tRNA-FRET. Nucleic Acids Research 48:6, pages e32-e32.
Crossref
Jianjing YangDerek K. SmithHaoqi NiKe WuDongdong HuangSishi PanAdwait A. SatheYu TangMeng-Lu LiuChao Xing, Chun-Li ZhangQichuan Zhuge. (2020) SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells. Proceedings of the National Academy of Sciences 117:11, pages 5782-5790.
Crossref
Tapan Kumar Mohanta, Dhananjay Yadav, Abdullatif Khan, Abeer Hashem, Elsayed Fathi Abd_Allah & Ahmed Al-Harrasi. (2020) Analysis of genomic tRNA revealed presence of novel genomic features in cyanobacterial tRNA. Saudi Journal of Biological Sciences 27:1, pages 124-133.
Crossref
Zahra Motahari, Sally Ann Moody, Thomas Michael Maynard & Anthony-Samuel LaMantia. (2019) In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?. Journal of Neurodevelopmental Disorders 11:1.
Crossref
Dario VenezianoLuisa TomaselloVeronica BalattiAlexey PalamarchukLaura Z. Rassenti, Thomas J. Kipps, Yuri PekarskyCarlo M. Croce. (2019) Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences 116:48, pages 24252-24258.
Crossref
Ranad Shaheen, Paul Mark, Christopher T. Prevost, Adila AlKindi, Ahmad Alhag, Fatima Estwani, Tarfa Al‐Sheddi, Eman Alobeid, Mona M. Alenazi, Nour Ewida, Niema Ibrahim, Mais Hashem, Firdous Abdulwahab, Emily M. Bryant, Egidio Spinelli, John Millichap, Sarah S. Barnett, Hutton M. Kearney, Andrea Accogli, Marcello Scala, Valeria Capra, Vincenzo Nigro, Dragony Fu & Fowzan S. Alkuraya. (2019) Biallelic variants in CTU2 cause DREAM‐PL syndrome and impair thiolation of tRNA wobble U34 . Human Mutation 40:11, pages 2108-2120.
Crossref
Nicole R. Sexton & Gregory D. Ebel. (2019) Effects of Arbovirus Multi-Host Life Cycles on Dinucleotide and Codon Usage Patterns. Viruses 11:7, pages 643.
Crossref
Brian Y Lin, Patricia P Chan & Todd M Lowe. (2019) tRNAviz: explore and visualize tRNA sequence features. Nucleic Acids Research 47:W1, pages W542-W547.
Crossref
Vivek M. Advani & Pavel Ivanov. (2019) Translational Control under Stress: Reshaping the Translatome. BioEssays 41:5, pages 1900009.
Crossref
R. Jordan OntiverosJulian StouteKathy Fange Liu. (2019) The chemical diversity of RNA modifications. Biochemical Journal 476:8, pages 1227-1245.
Crossref
Jeremy T. Lant, Matthew D. Berg, Ilka U. Heinemann, Christopher J. Brandl & Patrick O’Donoghue. (2019) Pathways to disease from natural variations in human cytoplasmic tRNAs. Journal of Biological Chemistry 294:14, pages 5294-5308.
Crossref
Xumin Ou, Jingyu Cao, Anchun Cheng, Maikel P. Peppelenbosch & Qiuwei Pan. (2019) Errors in translational decoding: tRNA wobbling or misincorporation?. PLOS Genetics 15:3, pages e1008017.
Crossref
Katerina Grafanaki, Dimitrios Anastasakis, George Kyriakopoulos, Ilias Skeparnias, Sophia Georgiou & Constantinos Stathopoulos. (2019) Translation regulation in skin cancer from a tRNA point of view. Epigenomics 11:2, pages 215-245.
Crossref
Richard F Walker, Serban Ciotlos, Qing Mao, Robert Chin, Snezana Drmanac, Nina Barua, Misha R Agarwal, Rebecca Yu Zhang, Zhenyu Li, Michelle Ka Yan Wu, Kevin Sun, Katharine Lee, Staci Nguyen, Jia Sophie Liu, Paolo Carnevali, Radoje Drmanac & Brock A Peters. (2017) Clinical and genetic analysis of a rare syndrome associated with neoteny. Genetics in Medicine 20:5, pages 495-502.
Crossref
Tao Pan. (2018) Modifications and functional genomics of human transfer RNA. Cell Research 28:4, pages 395-404.
Crossref
Paul Schimmel. (2017) The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis. Nature Reviews Molecular Cell Biology 19:1, pages 45-58.
Crossref
Kyle S. Hoffman, Patrick O'Donoghue & Christopher J. Brandl. (2017) Mistranslation: from adaptations to applications. Biochimica et Biophysica Acta (BBA) - General Subjects 1861:11, pages 3070-3080.
Crossref
Richard J. Maraia, Sandy Mattijssen, Isabel Cruz‐Gallardo & Maria R. Conte. (2017) The La and related RNA ‐binding proteins (LARPs): structures, functions, and evolving perspectives . WIREs RNA 8:6.
Crossref
Molly E. Evans, Wesley C. Clark, Guanqun Zheng & Tao Pan. (2017) Determination of tRNA aminoacylation levels by high-throughput sequencing. Nucleic Acids Research 45:14, pages e133-e133.
Crossref
Matthew D Berg, Kyle S Hoffman, Julie Genereaux, Safee Mian, Ryan S Trussler, David B Haniford, Patrick O’Donoghue & Christopher J Brandl. (2017) Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae . Genetics 206:4, pages 1865-1879.
Crossref
Kyle S. Hoffman, Matthew D. Berg, Brian H. Shilton, Christopher J. Brandl & Patrick O'Donoghue. (2017) Genetic selection for mistranslation rescues a defective co-chaperone in yeast. Nucleic Acids Research 45:6, pages 3407-3421.
Crossref
Richard Maraia & Aneeshkumar Arimbasseri. (2017) Factors That Shape Eukaryotic tRNAomes:  Processing, Modification and Anticodon–Codon Use. Biomolecules 7:4, pages 26.
Crossref
Celine PrakashArndt Von Haeseler. (2017) An Enumerative Combinatorics Model for Fragmentation Patterns in RNA Sequencing Provides Insights into Nonuniformity of the Expected Fragment Starting-Point and Coverage Profile. Journal of Computational Biology 24:3, pages 200-212.
Crossref
Veronica Balatti, Yuri Pekarsky & Carlo M. Croce. 2017. miRNA and Cancer. miRNA and Cancer 173 187 .
Cristiane S. Alves, Renato Vicentini, Gustavo T. Duarte, Vitor F. Pinoti, Michel Vincentz & Fabio T. S. Nogueira. (2016) Genome-wide identification and characterization of tRNA-derived RNA fragments in land plants. Plant Molecular Biology 93:1-2, pages 35-48.
Crossref
Xiaoyun Wang, Christina R. Chow, Kazumi Ebine, Jiyoung Lee, Marsha R. Rosner, Tao Pan & Hidayatullah G. Munshi. (2016) Interaction of tRNA with MEK2 in pancreatic cancer cells. Scientific Reports 6:1.
Crossref
Aneeshkumar G. Arimbasseri & Richard J. Maraia. (2016) RNA Polymerase III Advances: Structural and tRNA Functional Views. Trends in Biochemical Sciences 41:6, pages 546-559.
Crossref
Ana Cristina Gomes, Anna J. Kordala, Rita Strack, Xiaoyun Wang, Renaud Geslain, Kamila Delaney, Wesley C. Clark, Robert Keenan & Tao Pan. (2016) A dual fluorescent reporter for the investigation of methionine mistranslation in live cells. RNA 22:3, pages 467-476.
Crossref
Deeksha Bhartiya & Vinod Scaria. (2016) Genomic variations in non-coding RNAs: Structure, function and regulation. Genomics 107:2-3, pages 59-68.
Crossref
Qing Li, Bin Hu, Guo-wen Hu, Chun-yuan Chen, Xin Niu, Juan Liu, Shu-min Zhou, Chang-qing Zhang, Yang Wang & Zhi-Feng Deng. (2016) tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis. Scientific Reports 6:1.
Crossref
J. Doherty & M. Guo. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 407 438 .
J. Doherty & M. Guo. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 309 340 .
Shawn M. Lyons, Marta M. Fay & Pavel Ivanov. 2016. Modified Nucleic Acids in Biology and Medicine. Modified Nucleic Acids in Biology and Medicine 27 54 .
Denis Susorov, Tatiana Mikhailova, Alexander Ivanov, Elizaveta Sokolova & Elena Alkalaeva. (2015) Stabilization of eukaryotic ribosomal termination complexes by deacylated tRNA. Nucleic Acids Research 43:6, pages 3332-3343.
Crossref
Sebastian Kirchner & Zoya Ignatova. (2014) Emerging roles of tRNA in adaptive translation, signalling dynamics and disease. Nature Reviews Genetics 16:2, pages 98-112.
Crossref
Yu FuInhan LeeYong Sun LeeXiaoyong Bao. (2015) Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases. Genomics & Informatics 13:4, pages 94.
Crossref
Paul Anderson & Pavel Ivanov. (2014) tRNA fragments in human health and disease. FEBS Letters 588:23, pages 4297-4304.
Crossref
Aristeidis G. Telonis, Phillipe Loher, Yohei Kirino & Isidore Rigoutsos. (2014) Nuclear and mitochondrial tRNA-lookalikes in the human genome. Frontiers in Genetics 5.
Crossref
Richard J. Maraia & James R. Iben. (2014) Different types of secondary information in the genetic code. RNA 20:7, pages 977-984.
Crossref
Emily M. Darrow & Brian P. Chadwick. (2014) A novel tRNA variable number tandem repeat at human chromosome 1q23.3 is implicated as a boundary element based on conservation of a CTCF motif in mouse. Nucleic Acids Research 42:10, pages 6421-6435.
Crossref