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Small GTPases Volume 1, 2010 - Issue 2

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p21-activated kinases in ErbB2-positive breast cancer

A new therapeutic target?

Luis E. Arias-Romero Fox Chase Cancer Center; Philadelphia, PA USA

Jonathan Chernoff Fox Chase Cancer Center; Philadelphia, PA USACorrespondence[email protected]

Pages 124-128 | Received 11 Oct 2010, Accepted 29 Oct 2010, Published online: 01 Sep 2010

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https://doi.org/10.4161/sgtp.1.2.14109

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Rahul Kanumuri, Roshni Saravanan, V. Pavithra, Sandhya Sundaram, Suresh K. Rayala & Ganesh Venkatraman. (2020) Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers. Gene 760, pages 144991.
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Yan Qian, Xu Wu, Haixiao Wang, Guowei Hou, Xiao Han & Wei Song. (2020) PAK1 silencing is synthetic lethal with CDK4/6 inhibition in gastric cancer cells via regulating PDK1 expression. Human Cell 33:2, pages 377-385.
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Maryam Farzaneh Behelgardi, Saber Zahri, Zahra Gholami Shahvir, Farhad Mashayekhi, Laleh Mirzanejad & S. Mohsen Asghari. (2020) Targeting signaling pathways of VEGFR1 and VEGFR2 as a potential target in the treatment of breast cancer. Molecular Biology Reports 47:3, pages 2061-2071.
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Yong Zhou, Ren-Gen Fan, Cheng-Lin Qin, Jing Jia, Xu-Dong Wu & Wen-Zhang Zha. (2018) LncRNA-H19 activates CDC42/PAK1 pathway to promote cell proliferation, migration and invasion by targeting miR-15b in hepatocellular carcinoma. Genomics.
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Liang He, Linlin Qu, Lijing Wei, Yan Chen & Jian Suo. (2017) Reduction of miR-132-3p contributes to gastric cancer proliferation by targeting MUC13. Molecular Medicine Reports 15:5, pages 3055-3061.
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Li-Fang He, Hong-Wu Xu, Min Chen, Zhi-Rong Xian, Xiao-Fen Wen, Min-Na Chen, Cai-Wen Du, Wen-He Huang, Jun-Dong Wu & Guo-Jun Zhang. (2016) Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling. Oncotarget 8:11, pages 17573-17585.
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Chetan Rane, William Senapedis, Erkan Baloglu, Yosef Landesman, Marsha Crochiere, Soumyasri Das-Gupta & Audrey Minden. (2017) A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth. Scientific Reports 7:1.
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Eya Wolfson, Maria Goldenberg, Shira Solomon, Amit Frishberg & Ronit Pinkas-Kramarski. (2016) Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer. Oncotarget 7:40, pages 65320-65334.
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Girdhari Rijal & Weimin Li. (2016) 3D scaffolds in breast cancer research. Biomaterials 81, pages 135-156.
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E. A. Avilova, O. E. Andreeva, V. A. Shatskaya & M. A. Krasil’nikov. (2015) The role of protein kinase PAK1 in the regulation of estrogen-independent growth of breast cancer. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 9:1, pages 58-62.
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Sercan Ergun, Tayeb Sadiq Tayeb, Ahmet Arslan, Ebru Temiz, Kaifee Arman, Muhammad Safdar, Hasan Da?l?Murat Korkmaz, G?lper Nacarkahya, Sevil K?rkbe?Serdar Oztuzcu. (2015) The investigation of miR-221-3p and PAK1 gene expressions in breast cancer cell lines. Gene 555:2, pages 377-381.
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Ragadeepthi Tunduguru, Tim T. Chiu, Latha Ramalingam, Jeffrey S. Elmendorf, Amira Klip & Debbie C. Thurmond. (2014) Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells. Biochemical Pharmacology 92:2, pages 380-388.
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Ge Meng, Chan Tian, Hui Wang, Yin Xu, Bao-Yun Zhang, Qi Shi, Chen Gao, Cao Chen, Xue-Yu Fan, Jing Wang, Kang Xiao, Ke Ren, Ming-Ming Xue & Xiao-Ping Dong. (2014) Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss. Medical Microbiology and Immunology 203:5, pages 291-302.
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Yong‐jun Wu, Yi Tang, Zhen‐feng Li, Zheng Li, Yi Zhao, Zhen‐jiang Wu & Qi Su. (2013) Expression and significance of R ac1, P ak1 and R ock1 in gastric carcinoma . Asia-Pacific Journal of Clinical Oncology 10:2.
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E.A. Avilova, O.E. Andreeva, V.A. Shatskaya & M.A. Krasilnikov. (2014) The role of protein kinase PAK1 in the regulation of estrogen-independent growth of breast cancer. Biomeditsinskaya Khimiya 60:3, pages 322-331.
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Maria Radu, Galina Semenova, Rachelle Kosoff & Jonathan Chernoff. (2013) PAK signalling during the development and progression of cancer. Nature Reviews Cancer 14:1, pages 13-25.
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L E Wong, N Chen, V Karantza & A Minden. (2013) The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells. Oncogenesis 2:6, pages e50-e50.
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Adrienne M. Dorrance, Serena De VitaMaria Radu, Pavankumar N. G. ReddyMeaghan K. McGuinnessChad E. HarrisRonald MathieuSteven W. LaneRachelle Kosoff, Michael D. MilsomJonathan Chernoff & David A. Williams. (2013) The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood 121:13, pages 2474-2482.
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Nhi Huynh, Mildred Yim, Jonathan Chernoff, Arthur Shulkes, Graham S. Baldwin & Hong He. (2013) p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. American Journal of Physiology-Gastrointestinal and Liver Physiology 304:6, pages G561-G567.
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Kimberly A. Malecka, Zsofia Szentpetery & Jeffrey R. Peterson. (2013) Synergistic Activation of p21-activated Kinase 1 by Phosphatidylinositol 4,5-Bisphosphate and Rho GTPases. Journal of Biological Chemistry 288:13, pages 8887-8897.
Crossref

Suranganie Dharmawardhane, Eliud Hernandez & Cornelis Vlaar. 2013. Inhibitors of the Ras Superfamily G-proteins, Part A. Inhibitors of the Ras Superfamily G-proteins, Part A 117 146 .

Subhash C. Chauhan, Mara C. Ebeling, Diane M. Maher, Michael D. Koch, Akira Watanabe, Hiroyuki Aburatani, Yuhlong Lio & Meena Jaggi. (2012) MUC13 Mucin Augments Pancreatic Tumorigenesis. Molecular Cancer Therapeutics 11:1, pages 24-33.
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Zhanxiang Wang, Eunjin Oh, D. Wade Clapp, Jonathan Chernoff & Debbie C. Thurmond. (2011) Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo. Journal of Biological Chemistry 286:48, pages 41359-41367.
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p21-activated kinases in ErbB2-positive breast cancer

A new therapeutic target?

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p21-activated kinases in ErbB2-positive breast cancer

A new therapeutic target?

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