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Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile

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Pages 3605-3619 | Published online: 16 Apr 2014

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Irina Nikolova, Lyubomir Marinov, Ani Georgieva, Reneta Toshkova, Martin Malchev, Yulian Voynikov & Ivanka Kostadinova. (2018) Metamizole (dipyrone) – cytotoxic and antiproliferative effects on HeLa, HT-29 and MCF-7 cancer cell lines. Biotechnology & Biotechnological Equipment 32:5, pages 1327-1337.
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Articles from other publishers (31)

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Raphael Allgaier, Arne Kandulski, Karsten Gülow, Lars Maier, Martina Müller & Hauke Christian Tews. (2023) Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose. Drugs in R&D 23:2, pages 93-98.
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Jovica Branković, Vesna M. Milovanović, Zorica D. Petrović, Dušica Simijonović & Vladimir P. Petrović. (2023) Pyrazolone-type compounds (part II): in vitro and in silico evaluation of antioxidant potential; structure–activity relationship . RSC Advances 13:5, pages 2884-2895.
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Georgiana Lupu, Lucia Bel & Sanda Andrei. (2022) Pain Management and Analgesics Used in Small Mammals during Post-Operative Period with an Emphasis on Metamizole (Dipyrone) as an Alternative Medication. Molecules 27:21, pages 7434.
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Evelina Z. Gavazova & Daniela D. Grekova-Kafalova. (2022) Pharmaceutical Care for Patients with Headache. Folia Medica 64:3, pages 373-379.
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Stevan Orović, Nataša Petković, Jelena Bulatović & Dušica Stamenković. (2022) Nonopioid analgesics for analgesia in critically ill patients: Friends, enemies, or collaborators. Serbian Journal of Anesthesia and Intensive Therapy 44:5-6, pages 115-129.
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Julia Lieser, Claudia Schwedes, Maria Walter, Judith Langenstein, Andreas Moritz & Natali Bauer. (2021) Oxidative damage of canine erythrocytes after treatment with non-steroidal anti-inflammatory drugs. Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 49:06, pages 407-413.
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İsmet Yılmaz, Zeynep Maraş, Yılmaz Uğur, Mustafa Erkan Özgür, Murat Durmaz, Halil İbrahim Ulusoy & Selim Erdoğan. (2021) Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses. Journal of Veterinary Pharmacology and Therapeutics 44:6, pages 927-936.
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Jitka Rychlíčková & Hana Jurečková. (2021) Metamizole (dipyrone). Klinická farmakologie a farmacie 35:2, pages 94-98.
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Tsahi T. Lerman, Moshe Sagi, Yair Shafir, Liron Sheena, Eytan Cohen, Elad Goldberg & Ilan Krause. (2021) A possible increased risk of metamizole‐associated neutropenia among COVID‐19 patients. British Journal of Clinical Pharmacology 87:7, pages 2902-2906.
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Arnim Johannes Gaebler, Georgios Schoretsanitis, Nagia Ben Omar, Ekkehard Haen, Katharina Endres, Christoph Hiemke & Michael Paulzen. (2020) Metamizole but not ibuprofen reduces the plasma concentration of sertraline: Implications for the concurrent treatment of pain and depression/anxiety disorders. British Journal of Clinical Pharmacology 87:3, pages 1111-1119.
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Petra Rozsívalová, Radek Štichhauer, Lucie Holická, Pavel Rozsíval, Marie Kopecká, Sylva Skálová & Josef Malý. (2020) Metamizol in paediatric pain management. Pediatrie pro praxi 21:5, pages 323-329.
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Silvana Russo & Walter Filgueira de Azevedo. (2020) Computational Analysis of Dipyrone Metabolite 4-Aminoantipyrine As A Cannabinoid Receptor 1 Agonist. Current Medicinal Chemistry 27:28, pages 4741-4749.
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Luciana G Teixeira, Letícia R Martins, Paula I Schimites, Guilherme L Dornelles, Graciane Aiello, Juliana S Oliveira, Filipe C da Silva, Bárbara TS Brum, Thais MC Walter, Cinthia M Andrade & André V Soares. (2019) Evaluation of postoperative pain and toxicological aspects of the use of dipyrone and tramadol in cats. Journal of Feline Medicine and Surgery 22:6, pages 467-475.
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Aymen Ali Al-Qurain, Lemlem G. Gebremichael, Muhammad Suleman Khan, Desmond B. Williams, Lorraine Mackenzie, Craig Phillips, Patrick Russell, Michael S. Roberts & Michael D. Wiese. (2020) Prevalence and Factors Associated with Analgesic Prescribing in Poly-Medicated Elderly Patients. Drugs & Aging 37:4, pages 291-300.
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Mathias Lutz. (2019) Metamizole (Dipyrone) and the Liver: A Review of the Literature. The Journal of Clinical Pharmacology 59:11, pages 1433-1442.
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Anna Oleárová & Katarína Jurečková. (2019) Metamizole‑affected onset of action of filgrastim. Klinická farmakologie a farmacie 33:3, pages 46-49.
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Chang Wang, Yuehua Chen, Jingyu Li, Leijie Zhou, Bo Wang, Yumei Xiao & Hongchao Guo. (2019) Phosphine-Catalyzed Asymmetric Cycloaddition Reaction of Diazenes: Enantioselective Synthesis of Chiral Dihydropyrazoles. Organic Letters 21:18, pages 7519-7523.
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Sigalit Caspi, Ronit Meidan, Elad Peless & Ela Raizman. (2019) Nurse-initiated oral opioid pain protocol improves the quality of musculoskeletal pain management in the emergency department. International Emergency Nursing 43, pages 29-33.
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Robert H. Schüchen, Martin Mücke, Milka Marinova, Dmitrij Kravchenko, Winfried Häuser, Lukas Radbruch & Rupert Conrad. (2018) Systematic review and meta-analysis on non-opioid analgesics in palliative medicine. Journal of Cachexia, Sarcopenia and Muscle 9:7, pages 1235-1254.
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Mohammed Aboukaoud, Shoshana Israel, Chaim Brautbar & Sara Eyal. (2018) Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab Populations. Pharmaceutical Research 35:11.
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Milijana Miljkovic, Viktorija Dragojevic-Simic, Nemanja Rancic, Radoje Simic, Tanja Pekez-Pavlisko, Aleksandra Kovacevic & Dusica Stamenkovic. (2018) Metamizole Utilization and Expenditure During 6-Year Period: Serbia vs. Croatia. Frontiers in Public Health 6.
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B. Lebkowska-Wieruszewska, T. W. Kim, B. Chea, H. Owen, A. Poapolathep & M. Giorgi. (2018) Pharmacokinetic profiles of the two major active metabolites of metamizole (dipyrone) in cats following three different routes of administration. Journal of Veterinary Pharmacology and Therapeutics 41:2, pages 334-339.
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Victor Hugo González-Cárdenas, Luis A. Laverde-Gaona, Sergio H. Cabarique-Serrano, Nataly Cháves-Rojas, Jorge A. Reina-Sierra, Juan S. Infante, Laura M. Quiroz-Díaz & Victor D. Meneses. (2018) Analysis of the incidence of adverse events related to the administration of dipyrone. Colombian Journal of Anesthesiology 46:2, pages 119-125.
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Milijana MiljkovićN.N., Nemanja RančićK.K., Radoje SimićM.M., Dušica StamenkovićM.M. & Viktorija Dragojević-SimićM.M.. (2018) Metamizole: Current status of the safety and efficacy. Hospital Pharmacology - International Multidisciplinary Journal 5:3, pages 694-704.
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Leslie Hearn, Sheena Derry & R Andrew Moore. (2016) Single dose dipyrone (metamizole) for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2019:5.
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Nina Méndez-Domínguez, Jorge Augusto Achach-Asaf, Luis Manuel Basso-García, Yazmín Berenice Quiñones-Pacheco & Salvador Gómez-Carro. (2016) Choque séptico secundario a fiebre por chikungunya no congénita en un lactante menor: caso clínico. Revista Chilena de Pediatría 87:2, pages 143-147.
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Martyna Rumin, Joanna Smajdor, Beata Paczosa-Bator & Robert Piech. (2016) Voltammetry and Flow Injection Analysis with Amperometric Detection for Sensitive Sodium Metamizole Determination on Glassy Carbon Electrode Modified with SWCNTs/Nafion. ECS Journal of Solid State Science and Technology 5:8, pages M3005-M3011.
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K.S. Kalchofner Guerrero, A. Schwarz, R. Wuhrmann, S. Feldmann, S. Hartnack & R. Bettschart-Wolfensberger. (2015) Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy. The Veterinary Journal 204:1, pages 99-104.
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Amin Polzin, Stefan Richter, Karsten Schrör, Tienush Rassaf, Marc W. Merx, Malte Kelm, Thomas Hohlfeld & Tobias Zeus. (2017) Prevention of dipyrone (metamizole) induced inhibition of aspirin antiplatelet effects. Thrombosis and Haemostasis 114:07, pages 87-95.
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Catherine R. Van Son & Oksana Stasyuk. (2014) Older immigrants from the former Soviet Union and their use of complementary and alternative medicine. Geriatric Nursing 35:2, pages S45-S48.
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