118
Views
4
CrossRef citations to date
0
Altmetric
Voltammetry

Electrochemical Determination of Levodopa and Cabergoline by a Magnetic Core-Shell Iron (II,III) Oxide@Silica/Multiwalled Carbon Nanotube/Ionic Liquid/2-(4-Oxo-3-Phenyl-3,4-Dihydroquinazolinyl)- N′-Phenyl-Hydrazine Carbothioamide (FSCNT/IL/2PHC) Modified Carbon Paste Electrode

, , , &
Pages 2638-2654 | Received 28 Sep 2020, Accepted 20 Jan 2021, Published online: 24 Feb 2021
 

Abstract

This study reports a highly selective and sensitive electrochemical technique for levodopa and cabegoline based on the enhanced electrochemical response to magnetic core-shell Fe3O4@SiO2/multiwalled carbon nanotubes nanocomposite/N-butylpyridinium hexafluorophosphate (as an ionic liquid [IL])/2-(4-oxo-3-phenyl-3,4-dihydroquinazolinyl)-N′-phenyl-hydrazine-carbothioamide (2PHC) modified carbon paste electrode (FSCNT/IL/2PHC/CPE). Therefore differential pulse voltammetry (DPV) and the cyclic voltammetry (CV) were utilized to examine the electrocatalysis of levodopa and cabergoline at the modified electrode. After optimizing the conditions, the sensor had favorable electrochemical responses toward levodopa and cabergoline. DPV indicated a significantly higher electrochemical signal for levodopa and cabergoline at the modified electrode, which provides the sensitivity of the sensor for the analytes. The peak current for levodopa was linear between 0.06 and 400.0 µM with a limit of detection of 0.02 µM. In addition, the modified CPE was used to determine cabergoline from 0.07 to 350.0 µM with a limit of detection of 0.019 µM. This sensor was employed to simultaneously determine cabergoline and levodopa in urine, serum, and pharmaceuticals.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This article does not contain studies involving human participants or animals.

Additional information

Funding

This work was supported by the Kerman University of Medical Sciences by Grant number 940660.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 768.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.