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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 15
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Articles

Hybrid chitosan/amniotic membrane-based hydrogels for articular cartilage tissue engineering application

Tatiane Venturott ToniatoInstitute of Research and Development, University of Vale do Paraiba, São Paulo, Brazil; View further author information
,
Thiago Domingues StoccoFaculty of Medical Sciences, State University of Campinas, São Paulo, Brazil; ;Faculty of Physiotherapy, University of Santo Amaro, São Paulo, Brazil; View further author information
,
Danilo dos Santos MartinsSão Carlos Institute of Chemistry, University of São Paulo, São Paulo, Brazil; View further author information
,
Luciana Barros SantannaLaboratory of Immunology, University of Vale do Paraiba, São Paulo, Brazil; View further author information
,
Carla Roberta TimScientific and Technological Institute, Brasil University, São Paulo, Brazil; View further author information
,
Fernanda Roberta MarcianoDepartment of Physics, Federal University of Piauí, Teresina, Piauí, Brazil; ORCID Iconhttp://orcid.org/0000-0001-7740-8766View further author information
ORCID Icon,
Edson Cavalcanti Silva-FilhoLIMAV-Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI-Federal University of Piauí, Teresina, Piauí, BrazilView further author information
,
Sérgio Paulo Campana-FilhoSão Carlos Institute of Chemistry, University of São Paulo, São Paulo, Brazil; ORCID Iconhttp://orcid.org/0000-0002-0980-0085View further author information
ORCID Icon &
Anderson de Oliveira LoboLIMAV-Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI-Federal University of Piauí, Teresina, Piauí, BrazilCorrespondence[email protected]; [email protected]
ORCID Iconhttp://orcid.org/0000-0002-2544-0438View further author information
ORCID Icon show all
Pages 961-970 | Received 02 Apr 2019, Accepted 22 Jun 2019, Published online: 09 Jul 2019
 
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Abstract

A hybrid hydrogel combining collagen and chitosan (Ch) and human amniotic membranes (AM) were produced. To produce hybrid hydrogels, a fixed concentration of chitosan (2%) was used, adding AM as a booster at the concentrations of 2.5, 5.0. and 10.0% (w/w). DSC curves showed the denaturation of collagen. The swelling capacity of hydrogels ranged between 333 ± 19% and 368 ± 28%. The groups Ch-1.0 mg/mL and Ch-2.0 mg/mL had an elastic modulus 27% higher than the other groups.

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Disclosure statement

The authors declare that there is no conflict of interest.

Additional information

Funding

This work was supported by the Sao Paulo Research Foundation (FAPESP) under Grant [16/01584-4] and National Council for Scientific and Technological Development (CNPq) under Grant [303752/2017-3].

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