Genetic variants influencing obesity-related traits in Japanese population

Abstract

Context: Adipose tissue is the main organ that stores energy and participates in adaptive thermogenesis of the human body. The adipose tissue content in an individual is determined by a combination of genetic factors and lifestyle related factors. While Japanese people, along with the closely related East Asians, are generally thinner than individuals of European ancestry, they are prone to accumulating visceral adipose tissues. Genome-wide discovery of loci influencing obesity-related traits, and application of the genome sequence data to assess natural selection, provides evidence that the obesity-related traits in East Asians might be shaped by natural selection.

Objective: This review aims to summarise health and evolutionary implications of genetic variants influencing obesity-related traits in Japanese.

Methods: This study gathered recently published papers of medical, genetic and evolutionary studies regarding obesity-related traits in the Japanese and closely related East Asians.

Results and conclusion: A high susceptibility to central obesity of Japanese and closely related East Asians might have been shaped by natural selection favouring thrifty genotypes. Moreover, natural selection favouring higher thermogenic activity of brown adipose tissues would contribute to increased non-thrifty alleles in ancestors of East Asians.

Keywords:

• Obesity
• visceral fat
• adaptation
• single nucleotide polymorphism

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by JSPS KAKENHI [Grant numbers 18H02515, 17H01453] and Grant-in-Aid for Scientific Research on Innovative Areas (Thermal Biology) [Grant number 18H04687] from MEXT.