Abstract
An efficient synthesis of new 4-hydroxy-3-(6-aryl-2-(arylamino) pyrimidin-4-yl) quinolin-2(1H)-ones 5a–j, 6a–j, and the evaluation of their antimicrobial activity have been described. Potent antibacterial activity was shown by 6a, 5e, 5f, 6h, 6i, 5j against the testes pathogenic bacteria. Also significant antifungal activity was shown by 6b, 6d, 5e toward selective fungal strains.
Acknowledgements
We sincerely thank to Mr. BRS Rao (Managing Director of LGC Promochem private limited, Bangalore) for his financial support. We thank to SAIF-VIT Vellore for providing NMR support. Also we wish to thank Dr. P. Sujjitha (Managing Director of UCHA herbs private limited, Hyderabad) for providing antimicrobial screening studies.
Disclosure statement
No potential conflict of interest was reported by the authors.