A review of controlled release from cyclodextrins: release methods, release systems and application

Abstract

The controlled release of guest molecules from cyclodextrin (CD) inclusion complexes is very important for specific industrial applications in foods, medicine, cosmetics, textiles, agriculture, environmental protection, and chemical materials. The term “controlled release” encompasses several related methods, including those referred to as immediate release, sustained release and targeted release. Many different CD-based controlled release systems are currently used in practical applications. CD inclusion complexes, CD coupling, supramolecular hydrogels, and supramolecular micelles are among the most common. This review systematically introduces the principles and applications of CD-based controlled release systems, providing a theoretical basis for improving the bioavailability of effective substances and broadening their range of application.

Keywords:

• Controlled release
• cyclodextrins
• industrial application
• release methods
• release systems

Acknowledgements

The authors thank Dr. Tod P. Holler of TPH Communications LLC for English language assistance.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 32072171), the Fundamental Research Funds for the Central Universities (JUSRP221007), the National First-class Discipline Program of Food Science and Technology (JUFSTR20180204), and the China Agriculture Research System (CARS-02).