Advances in the study of P(O)-N bond construction

Abstract

Phosphoramides represent an important class of organophosphorus compounds that have widespread applications in industry, agriculture, chemical synthesis as well as biomedicine. Researchers have conducted intensive and extensive studies on the properties and synthetic methods of phosphamides, including optimization and improvement of the preparative procedures and expansion of compound types. This paper presents an overview of the classical and recently reported methods for efficient construction of P-N bonds.

Graphical abstract

Keywords:

• P(O)-N bond
• P-N bond
• phosphoramidite
• chiral phosphonamide

Disclosure statement

The author declares no conflict of interest, financial or otherwise.