The role of antibody delivery formation in cancer therapy

Abstract

Cancer has become one of the major threats to human survival. Because of antibodies specificity and low toxicity, it is the primary choice to diagnose and treat cancer. It is easy to be cleared from the blood circulation or distributing throughout the body and causes unnecessary side effects. It is necessary to delivery antibodies to the tumour region in a stable, safe and effective manner. In this review, we discuss the latest studies that aimed to delivery antibodies to tumour sites via several vector forms, such as liposomes, carbon nanomaterials, and gold nanomaterials. How to deliver antibodies to the target site is a difficulty for antibody therapy. This review summarises the antibody’s therapeutic forms and carrier materials in recent years, and to explore how antibodies can be safely and stably delivered to the target site.

Keywords:

• Antibody
• antibody-drug conjugate
• liposome
• delivery system
• nanoparticle

Disclosure statement

The authors have no relevant affiliations or financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Additional information

Funding

This paper was supported by The National Natural Science Foundation of China [No. 21873057], The Fundamental Research Funds of Shandong University [No. 2018JC006], Shandong Provincial Natural Science Foundation of China [No. ZR2019MB041].