Vitamin D inadequacy combined with high BMI affects paraspinal muscle atrophy and pain intensity in postmenopausal women

Abstract

Objective

This study was performed to assess the effects of vitamin D deficiency/insufficiency combined with a high body mass index (BMI) on paraspinal muscle (PSM) atrophy and pain intensity in postmenopausal women with lower back pain (LBP).

Methods

In total, 365 postmenopausal women were analyzed in the study. We divided the women into four groups according to BMI and vitamin D status. Outcome measurements included PSM atrophy, fatty infiltration (FI) and severity of LBP. Binary logistic regression was used to analyze the odds ratio (OR), and the interaction between the BMI and vitamin D status was tested.

Results

Compared with the control group, the high BMI with vitamin D deficiency/insufficiency group had a significantly increased risk of FI > grade 2 (OR = 10.69, p < 0.001), hand grip strength of <16 kg (OR = 8.96, p < 0.001), Short Physical Performance Battery score of ≤8 (OR = 3.69, p < 0.001) and visual analog scale (VAS) score of >3 (OR = 4.76, p < 0.001). A significant positive additive interaction was found between the BMI and vitamin D status on PSM atrophy.

Conclusion

Vitamin D deficiency/insufficiency combined with a high BMI was associated with PSM atrophy and LBP intensity in postmenopausal women. The interaction analysis showed a positive additive interaction between BMI and vitamin D status.

摘要

目的：本研究旨在探讨维生素D缺乏/不足合并高体重指数（BMI）对绝经后下腰痛（LBP）女性椎旁肌（PSM）萎缩和疼痛强度的影响。

方法：本研究总共分析了365名绝经后女性。我们根据BMI和维生素D状况将这些女性分为4组。结局评估包括PSM萎缩、脂肪渗透（FI）和LBP的严重程度。用二元Logistic回归分析优势比（OR）, 并检验BMI与维生素D水平之间的交互作用。

结果：与对照组相比, 高BMI伴维生素D缺乏/不足组发生FI>2级（OR =10.69, p < 0.001）, 手握力<16 Kg（OR=8.96, p < 0.001）, 短的物理性能电池评分≤8（OR=3.69, p < 0.001）, 视觉模拟评分（VAS）>3的风险显著增加（OR= 4.76, p < 0.001）。在PSM萎缩中, BMI和维生素D水平之间存在显著的正相加交互作用。

结论：在绝经后女性中, 维生素D缺乏/不足合并高BMI与PSM萎缩和LBP强度相关。交互作用分析表明, BMI与维生素D水平之间存在正相加交互作用。

Keywords:

• Vitamin D
• body mass index
• paraspinal muscle
• postmenopausal women

Potential conflict of interest

H. Chen, H.-W. Xu, S.-B. Zhang, Y.-Y. Yi and S.-J. Wang declare that they have no conflict of interest.

Additional information

Funding

This work was funded by the Special Program for Research on Healthy Aging of Shanghai Municipal Health Commission [2020YJZX0116]; National Natural Science Foundation of China [81572181]; Science and Technology project of Jiangxi Provincial Health Commission [202140997].