Fabrication and characterization of novel semi-IPN hydrogels based on xanthan gum and polyvinyl pyrrolidone-co-poly (2-acrylamido-2-methyl propane sulfonic acid) for the controlled delivery of venlafaxine

ABSTRACT

Fabrication of chemically crosslinked matrix system for controlled delivery of venlafaxine is the aim of study. AMPS (monomer) is used to chemically cross-link PVP (polymer) and Xanthan gum (Polymer) in the presence of ammonium per sulfate/sodium hydrogen sulfite. The effect of alteration in the amount of monomer, polymer, and crosslinker was evaluated. Swelling properties showed maximum swelling at pH 7.4 proved to indicate the pH-sensitive behavior. Kinetics modeling demonstrated the controlled release trend of venlafaxine in a fabricated gel. Toxicity studies confirmed the nontoxicity of developed gel. The controlled delivery of venlafaxine was effectively achieved by xanthan gum/PVP-co-poly (AMPS) hydrogels.

GRAPHICAL ABTRACT

KEYWORDS:

• Polyvinylpyrrolidone
• ethylene glycol dimethacrylate
• 2-acrylamido-2-methylpropane sulfonic acid
• swelling parameters
• controlled delivery

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

Usman Abid

Usman Abid obtained his M.Phil degree at The Islamia University of Bahawalpur, Pakistan. He completed his Pharm-D Degree at The Islamia University of Bahawalpur, Pakistan. Currently he is doing PhD. from Pakistan and he is Researcher at the Pharmaceutical lab BZU, Pakistan. His research fields are: nanotechnology and its latest advancements, sustained drug delivery, arthritis, colon cancer therapy, hydrogel drug delivery systems and polymers.

Fahad Pervaiz

Dr. Fahad Pervaiz is working as Associate Professor of Pharmaceutics at the Islamia University of Bahawalpur, Pakistan. He got Ph.D. in Pharmaceutics from The Islamia University of Bahawalpur, Pakistan. He has successfully developed a research laboratory “Pharmaceutical Lab) at the Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan. Currently, he is heading the research group consists of Seven M.Phil and five Ph.D. scholars and focuses on the development of micro and nanoscale drug delivery systems that can provide innovative solutions to challenging clinical needs. His major research interest are Novel drug delivery, Nanotechnology, Pharmacokinetics, Mucoadhesive drug delivery systems and hydrogels.

Hina Shoukat

Hina Shoukat completed her University education in 2015 obtaining the degree of M.Phil. Pharmaceutics from The Islamia University of Bahawalpur, Pakistan. Currently she is working as PhD research scholar at the The Islamia University of Bahawalpur, Pakistan.

Sadia Rehman

Sadia Rehman completed her Pharm.D education and pursue the degree of M.Phil. in Pharmaceutics from, Pakistan. Currently she is working as PhD research scholar at the The Islamia University of Bahawalpur, Pakistan.

Sobia Abid

Sobia Abid completed her Pharm.D education The Islamia University of Bahawalpur, Pakistan. She want to excel in the research field.