Delmopinol – adsorption to and absorption through the oral mucosa

Figures & data

Table 1. Surface tension data for the test liquids used for the contact angle measurements.

Test liquid	Surface tension γLV (mN m^−1)
1. Glycerol	63.7
2. Thiodiglycol	53.5
3. Methylene iodide	51.7
4. s-Tetrabromoethane	47.8
5. Propylene carbonate	41.8
6. n-Hexane	18.9

Figure 1. Mean for all subjects for changes over time from baseline for the contact angles obtained for each test liquid. Note that the time-line is not linear. p<.05 and p<.01 are denoted as * and **, respectively.

Table 2. Mean, standard deviation (SD) and range for changes over time from baseline for the contact angles obtained for the test liquids applied.

Test liquid	Difference	Difference	Difference		Difference	Difference
	1 min – Baseline	30 min – Baseline	60 min – Baseline		120 min – Baseline	240 min – Baseline
	Mean (SD)	Mean (SD)	Mean (SD)		Mean (SD)	Mean (SD)
	N (range)	N (range)	N (range)		N (range)	N (range)
1. Glycerol	−40.5** (12.0)	−36.7 (13.4)	−23.0* (11.3)	−19.9* (11.7)		−19.2** (12.4)
	10 (−53.0 to −15.0)	10 (−58.0 to −10.0)	7 (−41.0 to −8.0)	7 (−34.0 to −2.0)		9 (−42.0 to 0.0)
2. Thiodiglycol	−31.0** (8.7)	−28.1 (14.3)	−17.0** (6.5)	−17.3 (15.4)		−7.5* (6.8)
	9 (−39.0 to −14.0)	8 (−44.0 to −9.0)	8 (−26.0 to −7.0)	4 (−39.0 to −5.0)		8 (−13.0 to 5.0)
3. Methylene iodide	−6.5 (8.9)	−10.7 (9.3)	−2.9 (8.3)	−0.8 (10.3)		−2.0 (6.9)
	10 (−18.0 to 10.0)	9 (−24.0 to 2.0)	8 (−19.0 to 7.0)	8 (−15.0 to 18.0)		8 (−13.0 to 6.0)
4. s-Tetrabromoethane	−0.7 (10.5)	6.3 (18.4)	0.2 (17.9)	7.6 (25.5)		1.8 (12.6)
	10 (−19.0 to 16.0)	8 (−25.0 to 28.0)	9 (−19.0 to 37.0)	8 (−19.0 to 63.0)		8 (−11.0 to 26.0)
5. Propylene carbonate	3.5 (12.9)	0.6 (5.8)	1.0 (5.7)	2.7 (8.9)		1.5 (6.5)
	10 (−5.0 to 40.0)	10 (−5.0 to 16.0)	10 (−5.0 to 15.0)	10 (−5.0 to 27.0)		8 (−5.0 to 17.0)
6. n-Hexane	0.0 (0.0)	0.0 (0.0)	0.0 (0.0)	0.0 (0.0)		0.0 (0.0)
	10 (0.0 to 0.0)	10 (0.0 to 0.0)	10 (0.0 to 0.0)	10 (0.0 to 0.0)		9 (0.0 to 0.0)

*p < .05, **p < .01. Test for changes over time with Fisher’s non-parametric permutation test for matched pairs.

Figure 2. Whole-body autoradiograms of male Sprague-Dawley rats painted with solutions of ¹⁴C-delmopinol in the mouth and killed after (A) 1 h, (B) 4 h and (C) 24 h.

Figure 3. (A) Autoradiogram of a transversal section through the head of a Sprague-Dawley rat killed 1 h after painting of the mouth with a solution of ¹⁴C-delmopinol. (B) The corresponding tissue-section.