Delmopinol – adsorption to and absorption through the oral mucosa

References

• Simonsson T, Hvid EB, Rundegren J, et al. Effect of delmopinol on in vitro dental plaque formation, bacterial acid production and the number of microorganisms in human saliva. Oral Microbiol Immunol. 1991;6:305–309.
   PubMedGoogle Scholar
• Steinberg D, Beeman D, Bowen WH. The effect of delmopinol on glucosyltransferase adsorbed on to saliva-coated hydroxyapatite. Arch Oral Biol. 1992;37:33–38.
   PubMed Web of Science ®Google Scholar
• Rundegren J, Simonsson T, Petersson L, et al. Effect of delmopinol on the cohesion of glucan-containing plaque formed by Streptococcus mutans in a flow cell system. J Dent Res. 1992;71:1792–1796.
   PubMed Web of Science ®Google Scholar
• Rundegren J, Arnebrant T. Effect of delmopinol on the viscosity of extracellular glucans produced by Streptococcus mutans. Caries Res. 1992;26:281–285.
   PubMed Web of Science ®Google Scholar
• Elworthy AJ, Wade WG. Antimicrobial properties of delmopinol against oral bacteria. Lett Appl Microbiol. 1995;20:191–194.
   PubMed Web of Science ®Google Scholar
• Collaert B, Attstrom R, Bruyn H, et al. The effect of delmopinol rinsing on dental plaque formation and gingivitis healing. J Clin Periodontol. 1992;19:274–280.
   PubMed Web of Science ®Google Scholar
• Collaert B, Edwardsson S, Attström R, et al. Rinsing with delmopinol 0.2% and chlorhexidine 0.2%: short-term effect on salivary microbiology, plaque, and gingivitis. J Periodontol. 1992;63:618–625.
   PubMed Web of Science ®Google Scholar
• Moran J, Addy M, Wade WG, et al. A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts. J Clin Periodontol. 1992;19:749–753.
   PubMed Web of Science ®Google Scholar
• Rundegren J, Bondesson Hvid E, Johansson M, et al. Effect of 4 days mouth rinsing with delmopinol or chlorhexidine on the vitality of plaque bacteria. J Clin Periodontol. 1992;19:322–325.
   PubMed Web of Science ®Google Scholar
• Sjödin T, Håkansson J, Sparre B, et al. Pharmacokinetics and clinical efficacy of delmopinol in an open rinse time study in healthy volunteers. Am J Dent. 2011;24:383–388.
   PubMed Web of Science ®Google Scholar
• Eriksson B, Hallström G, Ottersgård Brorsson AK, et al. Metabolic fate of delmopinol in man after mouth rinsing and after oral administration. Xenobiotica. 2000;30:179–192.
   PubMed Web of Science ®Google Scholar
• Eriksson B, Ottersgård Brorsson AK, Hallström G, et al. Pharmacokinetics of 14C-delmopinol in the healthy male volunteer. Xenobiotica. 1998;28:1075–1081.
   PubMed Web of Science ®Google Scholar
• Claydon N, Hunter L, Moran J, et al. A 6-month home-usage trial of 0.1% and 0.2% delmopinol mouthwashes (I). Effects on plaque, gingivitis, supragingival calculus and tooth staining. J Clin Periodontol. 1996;23:220–228.
   PubMed Web of Science ®Google Scholar
• EIworthy AJ, Edgar R, Moran J, et al. A 6-month home-usage trial of 0.1% and 0.2% delmopinol mouthwashes (II). Effects on the plaque microflora. J Clin Periodontol. 1995;22:527–532.
   PubMed Web of Science ®Google Scholar
• Hase J, Attström R, Edwardsson S, et al. 6-Month use of 0.2% delmopinol hydrochloride in comparison with chlorhexidine digluconate and placebo. (I). Effect on plaque formation and gingivitis. J Clin Periodontol. 1998;25:746–753.
   PubMed Web of Science ®Google Scholar
• Hase J, Edwardsson S, Rundegren J, et al. 6-Month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo (II). Effect on plaque and salivary microflora. J Clin Periodontol. 1998;25:841–849.
   PubMed Web of Science ®Google Scholar
• Lang N, Hase J, Grassi M, et al. Plaque formation and gingivitis after supervised mouthrinsing with 0.2% delmopinol hydrochloride, 0.2% chlorhexidine digluconate and placebo for 6 months. Oral Dis. 1998;4:105–113.
   PubMedGoogle Scholar
• Addy M, Moran J, Newcombe R. Meta-analyses of studies of 0.2% delmopinol mouth rinse as an adjunct to gingival health and plaque control measures. J Clin Periodontol. 2007;34:58–65.
   PubMed Web of Science ®Google Scholar
• Simonsson T, Arnebrant T, Petersson L. The effect of delmopinol on salivary pellicles, the wettability of tooth surfaces in vivo and bacterial cell surfaces in vitro. Biofouling. 1991;3:251–260.
   Google Scholar
• Zisman WA. Relations of the equilibrium contact angle to liquid and solid constitution. In: Gould R, editor. Contact angle, wettability and adhesion. Washington (DC): American Chemical Society; 1964. p. 1–51.
   Google Scholar
• Glantz PO, Jendresen MD, Baier RE. A clinical method for the study of in vivo adhesiveness of teeth. Acta Odontol Scand. 1980;38:371–378.
   PubMed Web of Science ®Google Scholar
• Bradley JV. Distribution-free statistical test. London. Prentice-Hall; 1968. p. 76–78.
   Google Scholar
• Ullberg S, Larsson B, Tjälve H. Autoradiography. In: HJ Glenn, editor. Biologic application of radiotracers. Boca Raton (FL): CRC Press; 1982. p. 56–108.
   Google Scholar
• Levine MJ. Salivary molecules. A structure/function synopsis. In: Malamud D, Tabak LA, editors. Saliva as a diagnostic fluid. New York: Annals of the New York Academy of Sciences; 1993. p. 11–16.
   Google Scholar
• Christersson CE, Dunford RG, Glantz PO, et al. Effect of critical surface tension on retention of oral microorganisms. Eur J Oral Sci. 1989;97:247–256.
   Google Scholar
• Christersson CE, Dunford RG. Salivary film formation on defined solid surfaces in the presence and absence of microorganisms. Biofouling. 1991;3:237–250.
   Google Scholar
• Svensson O, Halthur T, Sjödin T, et al. The adsorption of delmopinol at the solid/liquid interface – the role of the acid-base equilibrium. J Colloid Interface Sci. 2010;350:275–281.
   PubMed Web of Science ®Google Scholar
• Santos O, Lindh L, Halthur T, et al. Adsorption from saliva to silica and hydroxyapatite surfaces and elution of salivary films by SDS and delmopinol. Biofouling. 2010;26:697–710.
   PubMed Web of Science ®Google Scholar
• Vassilakos N, Arnebrant T, Rundegren J. In vitro interactions of delmopinol hydrochloride with salivary films adsorbed at solid/liquid interfaces. Caries Res. 1993;27:176–182.
   PubMed Web of Science ®Google Scholar
• Bonesvoll P. Oral pharmacology of chlorhexidine. J Clin Pharmacol. 1977;4:49–65.
   Google Scholar
• Rushton A. Safety of hibitane. II. Human experience. J Clin Periodontol. 1977;4:73–79.
   PubMed Web of Science ®Google Scholar
• Aframian DJ, Davidowitz T, Benoliel R. The distribution of oral mucosal pH values in healthy saliva secretors. Oral Dis. 2006;12:420–423.
   PubMed Web of Science ®Google Scholar
• Bartlett J, van der Voort Maarschalk K. Understanding the oral mucosal absorption and resulting clinical pharmacokinetics of asenapine. AAPS PharmSciTech. 2012;13:1110–1115.
   PubMed Web of Science ®Google Scholar