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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 17
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Original Articles

Novel Synthesis of Fosphenytoin: Anti-Convulsant Prodrug

Chandrashekar R. Elati Innovation Plaza, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
,
Srinivas Gangula Innovation Plaza, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
,
Anitha Naredla Innovation Plaza, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
,
S. Ashok Department of Chemistry, Osmania University, Hyderabad, India
,
Apurba Bhattacharya Innovation Plaza, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
&
Rakeshwarar Bandichhor Innovation Plaza, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, IndiaCorrespondence[email protected]
Pages 2950-2957 | Received 25 Dec 2007, Published online: 28 Aug 2008
 
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Abstract

A simple, new synthesis of fosphenytoin sodium 1, a prodrug, via imidate ester and employing mild reaction conditions is described.

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Errata

ACKNOWLEDGMENT

The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work. We thank Dr. Y. Ravindra Kumar for discussion related to NMR spectroscopy.

Notes

a Treatment of 3 with K2CO3 in the absence of CCl3CN.

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