An easy-to-operate n-carbonylation of indoles with diaryl carbonates as reagent and Na₂CO₃ as catalyst

Abstract

Na₂CO₃ catalyzed N-carbonylation of indoles using diaryl carbonates as acylation reagent have been developed. It provided an efficient and simple method for the utilization of carbonates and the synthesis of N-carbonyl indoles. The reaction can be operated easily with Na₂CO₃ as catalyst in CH₃CN and the corresponding products were isolated with good to excellent yields.

Graphical Abstract

Keywords:

• Sodium carbonate
• catalysis
• carbonylation
• indole
• carbonates