Abstract
An efficient and practical methodology was developed for rapid and green synthesis of novel benzofuran-1,2,4-oxadiazole-1,2,3-triazole hybrids (6a–n) from 5-(chloromethyl)-3-(2-methylbenzofuran-3-yl)-1,2,4-oxadiazoles (4a–b) by in situ generation of 5-(azidomethyl)-3-(2-methylbenzofuran-3-yl)-1,2,4-oxadiazoles followed by 1,3-dipolar cycloaddition with substituted-1-(prop-2-yn-1-yloxy)benzenes (5a–g) through Click reaction under mild reaction conditions with good to excellent yields (70–86%).
Graphical Abstract
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Acknowledgments
Authors thank the Head Department of Chemistry and CFRD, Osmania University, Hyderabad, India for providing laboratory facilities.