Glucose as an eco-friendly reducing agent for a one-pot multicomponent synthesis of quinoxalines

Abstract

An efficient and scalable one-pot multicomponent process is developed for the synthesis of quinoxalines by using D-glucose as a clean, renewable and an eco-friendly reductant in an alkaline aqueous medium. This protocol eliminates the nitro reduction by using pyrophoric metal catalysts like Pd, Ni, Zn, etc., and cyclization as separate steps for the synthesis of quinoxalines. Gram scale experiments and further substrate scope of the reaction have also been well demonstrated.

Graphical Abstract

Keywords:

• D-glucose
• eco-friendly reductant
• quinoxaline

Acknowledgements

The authors would like to thank APSL, Dr. Reddy’s Laboratory, Hyderabad, and the analytical team for providing facilities to carry out this work and analytical support, respectively.