Synthesis of the glycodendrimer macromolecule based on porphyrin as a targeted drug delivery system

Abstract

The present study synthesized a novel dendrimer with specific functional groups and use them as pharmaceutical carriers at the nanoscale. First, a glycodendrimer was synthesized and a porphyrin substance was selected as its core. Afterward, this substance was subsequently reacted with gallic acid and bromo valerate step-by-step and it was conjugated with acrylonitrile functionalized with Tris (hydroxymethyl) aminomethane. Eventually, the composition was reacted with Tris [α-D Manos (pyrazolyl oxy) methyl] methylamine and glycodendrimer (TTP-Tr-GD) was prepared via a divergent approach to develop drug delivery system. The nanocarrier was characterized using several techniques, such as scanning electron microscopy (FE-SEM), thermal analysis (TGA), NMR, Fourier transform infrared (FT-IR), differential laser scanning (DLS), elemental mapping (EDS), and Zeta potential. Effective factors on the release of the drug delivery, including the best time to absorb, sample pH, and reaction temperature were optimized. The statistically optimized sorption efficiency (98.11%) was attained at pH = 5.5, and a contact time of 15 min. As a result of the functional groups on the surface of the TTP-Tr-GD are appropriate for simultaneous determination and high throughput analysis of drug delivery system.

Keywords:

• Drug delivery system
• glycodendrimer
• macromolecule
• porphyrin