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Original Articles

The ALERRT® instrument: a quantitative measure of the effort required to compromise prescription opioid abuse-deterrent tablets

, PhD, , PhD, , MSc, PhD, DBE, , MS & , MD
Pages 291-298 | Received 06 Jul 2016, Accepted 27 Dec 2016, Published online: 13 Feb 2017

Figures & data

Figure 1. Example of a representative ALERRT evaluation form for 1 of the 10 household tools. *Not shown to scale.

Figure 1. Example of a representative ALERRT evaluation form for 1 of the 10 household tools. *Not shown to scale.

Table 1. ALERRT scores for each tablet by type of tool.

Figure 2. Mean (SD) overall ALERRT scores and differences in overall ALERRT scores between tablets. ADER-IMT = abuse-deterrent, extended-release injection-molded tablets; ER = extended release; IR = immediate release; VAS=visual analog scale. Values are the mean (SD) of the ALERRT scores for each tablet when collapsed across all 10 tools and all four raters. Tabular values are the differences in mean (SD) overall ALERRT scores for each tablet when collapsed across all 10 tools and all four raters.

Figure 2. Mean (SD) overall ALERRT scores and differences in overall ALERRT scores between tablets. ADER-IMT = abuse-deterrent, extended-release injection-molded tablets; ER = extended release; IR = immediate release; VAS=visual analog scale. Values are the mean (SD) of the ALERRT scores for each tablet when collapsed across all 10 tools and all four raters. Tabular values are the differences in mean (SD) overall ALERRT scores for each tablet when collapsed across all 10 tools and all four raters.

Figure 3. Mean (SD) overall ALERRT scores for individual tablets by rater. ADER-IMT = abuse-deterrent, extended-release injection-molded tablets; ER = extended release; IR = immediate release. Values are the mean (SD) of the ALERRT scores for each tablet for each rater when collapsed across all 10 tools.

Figure 3. Mean (SD) overall ALERRT scores for individual tablets by rater. ADER-IMT = abuse-deterrent, extended-release injection-molded tablets; ER = extended release; IR = immediate release. Values are the mean (SD) of the ALERRT scores for each tablet for each rater when collapsed across all 10 tools.

Figure 4. Mean (SD) duration of manipulation for individual tablets by preselected tool. ADER-IMT = abuse-deterrent, extended-release injection-molded tablets; ER = extended release; IR = immediate release. Values are the mean (SD) of the duration of manipulation for each tablet for each preselected tool when collapsed across all four raters, with a maximum of 300 seconds or until no further reduction in size was achieved.

Figure 4. Mean (SD) duration of manipulation for individual tablets by preselected tool. ADER-IMT = abuse-deterrent, extended-release injection-molded tablets; ER = extended release; IR = immediate release. Values are the mean (SD) of the duration of manipulation for each tablet for each preselected tool when collapsed across all four raters, with a maximum of 300 seconds or until no further reduction in size was achieved.

Table 2. Number of different outcomes* after manipulation of each tablet.