Figures & data
Table 1. Mean difficulty ratings and syringeable volume for syringeability tests on a scale of 1 (very easy to draw into a syringe) to 10 (impossible to draw into a syringe).
Figure 1. Representative samples of (a) intact, (b) cut, and (c) crushed morphine ARER tablets after a 10-min incubation in 5 mL room temperature water with agitation.
Notes: Panels on the left show the resulting mixture; panels on the right illustrate the attempts to draw the resulting solution into a syringe.
![Figure 1. Representative samples of (a) intact, (b) cut, and (c) crushed morphine ARER tablets after a 10-min incubation in 5 mL room temperature water with agitation.Notes: Panels on the left show the resulting mixture; panels on the right illustrate the attempts to draw the resulting solution into a syringe.](/cms/asset/e6933532-06bf-4f31-84f6-d0e8fc04479c/iada_a_1599383_f0001_oc.jpg)
Figure 2. Mean percentage of morphine released from crushed ER morphine after 1, 5, 10, and 30 min of 100 rpm agitation in 10 mL roomtemperature water.
Notes: Error bars = standard deviation; ER = extended-release; SD = standard deviation.
![Figure 2. Mean percentage of morphine released from crushed ER morphine after 1, 5, 10, and 30 min of 100 rpm agitation in 10 mL roomtemperature water.Notes: Error bars = standard deviation; ER = extended-release; SD = standard deviation.](/cms/asset/97074bdf-b947-4da8-884d-b5f0bc38a9fa/iada_a_1599383_f0002_b.gif)
Figure 3. Mean percentage of morphine released after 1, 5, 10, and 30 min in 1 mL, 5 mL, or 10 mL room temperature water with 100 rpm agitation for (a) intact, (b) cut, or (c) crushed morphine ARER tablets. Notes: Error bars = standard deviation; ER = extended-release; SD = standard deviation.
![Figure 3. Mean percentage of morphine released after 1, 5, 10, and 30 min in 1 mL, 5 mL, or 10 mL room temperature water with 100 rpm agitation for (a) intact, (b) cut, or (c) crushed morphine ARER tablets. Notes: Error bars = standard deviation; ER = extended-release; SD = standard deviation.](/cms/asset/b135066c-9426-4f55-a5cd-94df68771ae0/iada_a_1599383_f0003_b.gif)
Figure 4. Mean percentage of morphine released after 1, 5, 10, and 30 min in 1 mL, 5 mL, or 10 mL 90°C water with 100 rpm agitation for (a) intact, (b) cut, or (c) crushed morphine ARER tablets. Notes: Error bars = standard deviation; ER = extended-release; rpm = revolutions per minute; SD = standard deviation.
![Figure 4. Mean percentage of morphine released after 1, 5, 10, and 30 min in 1 mL, 5 mL, or 10 mL 90°C water with 100 rpm agitation for (a) intact, (b) cut, or (c) crushed morphine ARER tablets. Notes: Error bars = standard deviation; ER = extended-release; rpm = revolutions per minute; SD = standard deviation.](/cms/asset/e33c206d-ddcd-413f-946a-030e73ac6895/iada_a_1599383_f0004_c.jpg)