Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico

Figures & data

Table 1. Demographics (N = 86).

	M(SD) or %
Age	42.88 (7.88)
Sex
Male	100
Race
Caucasian/White	87.2
African American/Black	1.2
Native Hawaiian or Pacific Islander	2.3
Native American	3.5
Mixed Race	5.8
Hispanic/Latino
No	89.5
Yes	10.5
Education
High school Diploma or equivalent (GED)	9.3
Some college credit, no degree	26.7
Trade, Technical, Vocational training after high school	2.3
Associates degree	3.5
Bachelors Degree	31.4
Masters Degree	25.6
Advanced professional or Doctoral Degree (e.g., PhD, MD, etc.)	1.2
Marital or partnership status
Married and living with spouse	61.6
Living with partner	4.7
Divorced or separated	19.8
Never married	14
Non-Military Employment Status
Employed Full or Part time	80.2
Retired from nonmilitary employment	1.2
Unemployed	18.6

Table 2. Primary outcomes (mental health symptoms, suicidal ideation, and cognitive functioning) summary variables (N = 86).

	Baseline	1-month	3-month	6-month	F	Post-hoc	Partial Eta Squared
(N = 86)	M (SD)	M (SD)	M (SD)	M (SD)
SWLS	19.15 (7.25)	25.28 (6.99)	24.99 (6.60)	25.15 (6.39)	50.23***	BL <1 m = 3 m = 6 m	.371
PCL-5	35.16 (15.36)	18.44 (16.23)	17.77 (13.98)	18.41 (15.08)	60.14***	BL >1 m = 3 m = 6 m	.414
PHQ2	2.88 (1.88)	1.34 (1.59)	1.42 (1.56)	1.50 (1.54)	32.30***	BL >1 m = 3 m = 6 m	.275
GAD2	2.79 (1.74)	1.34 (1.52)	1.43 (1.43)	1.57 (1.55)	32.46***	BL >1 m = 3 m = 6 m	.276
ISI	14.67 (5.85)	9.90 (6.32)	9.62 (6.08)	9.29 (6.49)	45.92***	BL >1 m = 3 m = 6 m	.351
SDS	6.49 (3.37)	4.35 (4.31)	4.62 (4.42)	5.09 (4.54)	7.68***	BL >1 m = 3 m = 6 m	.083
AAQ-II	24.69 (9.60)	17.28 (8.98)	17.06 (8.57)	16.95 (8.84)	38.67***	BL >1 m = 3 m = 6 m	.313
MOS-CF	57.36 (19.15)	73.84 (20.08)	70.47 (20.64)	73.14 (18.82)	30.68***	BL <1 m = 3 m = 6 m	.265
NSI	31.48 (13.95)	18.84 (14.50)	20.31 (13.15)	19.35 (13.35)	54.09***	BL >1 m = 3 m = 6 m	.389
DEQ-A	15.06 (6.56)	9.63 (5.72)	9.44 (4.92)	9.19 (4.96)	57.12***	BL >1 m = 3 m = 6 m	.402
DSI-SS	1.03 (1.68)	.60 (1.40)	.70 (1.47)	.67 (1.43)	4.45**	BL >1 m	.050

Note: *p < .05, **p < .01, ***p < .001; Partial Eta Squared (small = 0.01; medium = 0.06; large = 0.14); BL=Baseline; 1 m=one-month; 3 m=three-month; 6 m=six-month.

SWLS: Satisfaction with Life Scale; PCL-5: Posttraumatic Stress Disorder Checklist; PHQ2: Patient Health Questionnaire-2; GAD-2: Generalized Anxiety Disorder-2; ISI: Insomnia Severity Index; SDS: Sheehan Disability Scale; AAQ-II: Acceptance and Action Questionnaire; MOS-CF: Medical Outcomes Study – Cognitive Functioning; NSI: Neurobehavioral Symptom Inventory; DEQ-A: Discrete Emotions Questionnaire – Anger Subscale; DSI-SS: Depressive Symptom Index Suicidality Subscale.

Data availability statement

Data is accessible via reasonable request to the corresponding author.