21st Century Early Adult (55-74) Deaths from Brain-Disease-Deaths Compared to All Other Cause Mortality in the Major Western Countries – Exposing a Hidden Epidemic

Figures & data

Table 1. Nervous disease deaths (NDD), Alzheimer and other dementia (Alz), mental and behavioural disorder deaths = brain disease deaths (BDD) 55–74 year olds rates per million 2000–2015 Ratio of Change. Ranked by highest BDD

Country and % change	NDD 55–74 2000-2015	Alzh 55–74 2000-2015	BD 55–74 2000–2015	BDD 55–74 2000-2015
1.Finland Ratio change	394–642 1.63	305–364 1.19	225–188 0.84 #	924–1194 1.29
2.Denmark Ratio change	339–398 1.17	115–204 1.77	312–518 1.66	766–1120 1.46
3.USA Ratio change	364–455 1.25	147–255 1.73	119–213 1.79	630–923 1.47
4.Netherlands Ratio change	350–379 1.08	116–223 1.92	151–245 1.62	617–847 1.37
5.UK Ratio change	256–399 1.56	164–254 1.55	106–180 1.70	526–833 1.58
6.Sweden Ratio change	267–387 1.45	157–239 1.52	241–198 0.82 #	665–824 1.24
7.Belgium Ratio change	377–383 1.02	206–172 0.83 #	188–218 1.16	771 773 1.00
8.Switzerland Ratio change	297–356 1.20	141–180 1.28	165–215 1.30	603–751 1.25
9.Norway Ratio change	365–390 1.07	125–176 1.39	161–182 1.13	651–748 1.15
10.Germany Ratio change	254–342 1.35	60–136 2.27	149–271 1.82	463–749 1.62
11.New Zealand 2013 Ratio change	279–314 1.13	129–161 1.25	151–245 1.62	559–720 1.29
12.Canada 2013 Ratio change	376–318 0.85 #	159–168 1.06	1.61–161 1.00	696–647 0.93 #
13.Australia Ratio change	272–335 1.23	105–171 1.63	108–126 1.17	485–632 1.30
14.France Ratio change	397–321 0.81 #	173–119 0.69 #	225–188 0.84 #	795–628 0.79 #
15.Ireland Ratio change	291–345 1.19	174–176 1.01	147–95 0.65 #	612–616 1.01
16.Austria Ratio change	160–286 1.79	74–129 1.74	97–198 2.04	331–613 1.85
17.Spain Ratio change	299–329 1.10	195–179 0.92	116–99 0.85 #	610–607 0.99
18.Italy Ratio change	266–327 1.23	186–143 0.77 #	71–82 1.15	523–552 1.06
19.Portugal Ratio change	230–290 1.26	144–142 0.99	31–88 2.84	405–520 1.28
20.Greece Ratio change	213–279 1.31	121–99 0.82 #	11–84 7.64	345–462 1.34
21.Japan Ratio change	123–180 1.46	28–26 0.93 #	19–28 1.47	170–234 1.38

Notes: # fall of BDD.

Table 2. EADs (55–74) all other causes vs. BDD rates per million 2000–2015. Confidence intervals AOC vs. BDD. Ranked by highest BDDs

Country and rank	All other EAD 2000–2015	EAD brain 2000 – 2015	Other: brain odds ratio	C.I other: brain low – high
1.Finland Ratio change	13,235–9150 0.68	924–11941.29	1.90	1.71-2.04
2.Denmark Ratio change	15,972–10,752 0.67	766–1120 1.46	2.18	1.97-2.39
3.USA Ratio change	14,603–10,457 0.72	630–923 1.47	2.04	1.84-2.27
4.Netherland Ratio change	13,804–9233 0.67	617–847 1.37	2.04	1.84-2.28
5.UK R change	14,982–9771 0.65	526–833 1.58	2.43	2.17-2.72
6.Sweden 2016 Ratio change	11,389–8838 0.78	665–824 1.24	1.59	1.44-1.78
7.Belgium Ratio change	13,498–9498 0.70	771–771 1.00	1.43	1.28-1.58
8.Germany Ratio change	13,890–10,907 0.79	463–749 1.62	2.05	1.83-2.32
9.Switzerland Ratio change	10,660–7574 0.71	603–751 1.25	1.76	1.57-1.96
10.Norway Ratio change	12,533–8231 0.66	651–748 1.15	1.74	1.57-1.95
11. New Zealand 13 Ratio change	12,847–8281 0.64	559–720 1.29	2.02	1.78-2.24
12.Canada 2013 Ratio change	11,848–8178 0.69	696–644 0.93	1.39	1.20-1.50
13.Australia Ratio change	11,090–7458 0.67	485–632 1.30	1.94	1.72-2.19
14.France 2014 Ratio change	11,698–8156 0.70	795–628 0.79 #	1.13	1.02-1.26
15.Ireland Ratio change	16,021–8843 0.55	612–616 1.01	1.84	1.63-2.05
16.Austria 2016 Ratio change	13,258–9924 0.75	331–613 1.85	2.47	2.16-2.84
17.Spain Ratio change	12,056–8286 0.69	610–607 0.99	1.43	1.29-1.63
18.Italy Ratio change	12,098–8351 0.69	523–542 1.04	1.51	1.33-1.70
19.Portugal Ratio change	14,571–9555 0.66	405–520 1.28	1.94	1.72-2.24
20.Greece Ratio change	13,281–10,032 0.76	345–462 1.34	1.76	1.54-2.04
21.Japan Ratio change	10,453–8238 0.79	170–234 1.38	1.75	1.43-2.13

• Notes: Correlating EAD AOC v BDD Rho = +0.3370 p < 0.1

Table 3. Age-standardised death rates all other cause vs. brain mortality 2000 vs. 2015: confidence intervals. Ranked by highest brain disease deaths

Country rank and year	All other	Ratio change	Total brain	Ratio change	Other: brain odds ratio	C.I. low – high
1.Finland 2015	4704 3368	0.72	543 617	1.14	1.58	1.40 -	1.80
2. UK 2015	4998 3527	0.71	234 517	2.21	3.11	2.67 -	3.68
3. Netherlands 2014–16	4885 3373	0.69	312 498	1.60	2.32	1.99 -	2.68
4. USA 2015	5259 4315	0.82	265 471	1.78	2.17	1.85 -	2.53
5. Denmark 2015	5455 3771	0.69	270 443	1.64	2.38	2.03 -	2.78
6 = Sweden 2014–16	4224 3206	0.76	321 411	1.28	1.68	1.45 -	1.97
6 =  Switzerland 2015 21	3983 2915	0.73	310 411	1.33	1.82	1.55 -	2.12
8. Canada 2011–13	4246 3286	0.71	290 377	1.30	1.83	1.43 -	1.97
9. Norway 2015	4633 3321	0.72	289 376	1.30	1.81	1.55 -	2.13
10. Germany 2015 2	5469 3803	0.70	195 370	1.90	2.71	2.28 -	3.26
11. Ireland 2012–14	5573 3713	0.70	209 352	1.68	2.40	2.12 -	3.01
12. Belgium 2015	4942 3732	0.76	287 349	1.22	1.61	1.37 -	1.89
13. Australia 2015 19	4067 3075	0.76	223 345	1.55	2.04	1.72 -	2.44
14. New Zealand 2011–13	4644 3564	0.77	223 315	1.41	1.83	1.54 -	2.20
15. Spain 2015 18	4325 3110	0.72	270 312	1.16	1.61	1.36 -	1.90
16. France 2012–14	4406 3313	0.75	286 291	1.02	1.36	1.14 -	1.60
17. Italy 2015	4296 3238	0.75	181 217	1.20	1.60	1.30 -	1.95
18. Austria 2014–66	4879 3219	0.66	103 201	1.95	2.95	2.32 -	3.77
19. Portugal 2012–14	5549 3944	0.71	97 192	1.98	2.79	2.17 -	3.57
20. Greece 2015	5145 3892	0.76	57 103	1.81	2.38	1.72 -	3.31
21. Japan 2015 20	3691 3007	0.81	44 77	1.75	2.16	1.48 -	3.12

Notes: AOC vs. BDD Rho = +0.1354 n.sig.

Table 4. Early adult deaths (EAD) (55–74) separate global categories in 10 MWC and average other categories to average BDD odds ratios

Country EAD	Circ	Can	Resp	Dig	Diab	Geni	BDD
Australia 2015 Ratio	3545 1676 0.47	5112 3821 0.75	939 636 0.68	371 338 0.91	349 246 0.71	123 89 0.72	485 632 1.30
Canada 2013 Ratio	3893 2056 0.53	5719 4310 0.75	827 673 0.81	532 463 0.87	451 291 0.65	180 105 0.58	696 644 0.93 #
France 2014 Ratio	3033 1479 0.49	5910 4617 0.78	622 386 0.62	711 510 0.72	295 175 0.59	121 72 0.60	795 628 0.79 #
Germany 2015 Ratio	5142 2991 0.58	5557 4767 0.86	795 853 1.07	849 673 0.79	319 252 0.79	143 164 1.15	463 749 1.62
Italy 2015 Ratio	3943 2114 0.54	5706 4438 0.78	589 410 0.70	712 389 0.55	419 311 0.74	139 109 0.78	523 542 1.04
Japan 2015 Ratio	2644 1828 0.69	4864 4071 0.84	858 710 0.83	473 363 0.77	168 108 0.64	156 141 0.90	170 234 1.38
Netherland 2016 Ratio	4632 1885 0.41	6003 5089 0.85	1094 730 0.67	463 333 0.72	337 186 0.55	148 98 0.66	617 847 1.37
Spain 2015 Ratio	3631 1897 0.52	5300 4289 0.91	1058 674 0.64	745 499 0.67	295 154 0.52	202 113 0.56	610 607 0.99
UK 2015 Ratio	5727 2557 0.45	5941 4733 0.80	1842 1228 0.67	684 642 0.94	183 102 0.56	131 103 0.79	526 833 1.58
USA 2016 Ratio	5508 3485 0.63	5893 4224 0.72	1470 1257 0.86	614 649 1.06	606 499 0.82	296 294 0.99	630 923 1.47
Average MWC ratios	0.53	0.81	0.76	0.72	0.60	0.77	1.25
Average other: BDD odds ratios	2.36	1.54	1.64	1.74	2.08	1.62	1.00

Notes: # BDD fall.

Abbreviations: Circ = circulatory; Can = cancer; Resp = respiratory; Dig = digestive; Diab = diabetes; Genit = genitourinary; BDD = brain disease deaths.

short-legendFigure 1.