2,429
Views
2
CrossRef citations to date
0
Altmetric
Review

Clinical applications of adipose-derived stromal vascular fraction in veterinary practice

ORCID Icon, ORCID Icon, , ORCID Icon, , , ORCID Icon & show all
Pages 151-166 | Received 21 Feb 2022, Accepted 13 Jul 2022, Published online: 08 Aug 2022

Figures & data

Figure 1. Steps involved in producing adipose-derived stromal vascular fraction (AdSVF) from adipose tissue collected from the fat depots using the enzymatic technique.

Figure 1. Steps involved in producing adipose-derived stromal vascular fraction (AdSVF) from adipose tissue collected from the fat depots using the enzymatic technique.

Figure 2. The major and minor cellular components present in the stromal vascular fraction: mature cells (adipocytes, smooth muscle cells, fibroblasts, endothelial; cells, and blood cells), progenitor cells (pre-adipocytes, endothelial progenitor cells, hematopoietic progenitors, and vascular progenitors), and stem cells (pericytes, mesenchymal stem cells, and hematopoietic stem cells).

Figure 2. The major and minor cellular components present in the stromal vascular fraction: mature cells (adipocytes, smooth muscle cells, fibroblasts, endothelial; cells, and blood cells), progenitor cells (pre-adipocytes, endothelial progenitor cells, hematopoietic progenitors, and vascular progenitors), and stem cells (pericytes, mesenchymal stem cells, and hematopoietic stem cells).

Figure 3. Cell morphologies of freshly isolated stromal vascular fraction (AdSVF) and cultured adipose-derived mesenchymal stem cells (AdMSCs) at passages 0 and 3. Reproduced from Zhou et al. (Citation2017) under Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Figure 3. Cell morphologies of freshly isolated stromal vascular fraction (AdSVF) and cultured adipose-derived mesenchymal stem cells (AdMSCs) at passages 0 and 3. Reproduced from Zhou et al. (Citation2017) under Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Figure 4. Applications of stromal vascular fraction (AdSVF) or adipose-derived stem cells (ASCs) in translational research involving pigs, horse, and sheep models and veterinary practice. ASCs/SVFs can be suspended in either platelet-rich plasma (PRP), phosphate-buffered saline (PBS), or 0.9% sodium chloride (saline). The suspended cells can be administered via different routes, including intra-lesional, intravenous injections (musculoskeletal injury treatment, cutaneous wound healing, acute respiratory distress syndrome), intracoronary delivery using balloon angioplasty catheter (cardiovascular disease), or insemination catheter (endometriosis). Reproduced from Bukowska et al. (Citation2021) under Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

Figure 4. Applications of stromal vascular fraction (AdSVF) or adipose-derived stem cells (ASCs) in translational research involving pigs, horse, and sheep models and veterinary practice. ASCs/SVFs can be suspended in either platelet-rich plasma (PRP), phosphate-buffered saline (PBS), or 0.9% sodium chloride (saline). The suspended cells can be administered via different routes, including intra-lesional, intravenous injections (musculoskeletal injury treatment, cutaneous wound healing, acute respiratory distress syndrome), intracoronary delivery using balloon angioplasty catheter (cardiovascular disease), or insemination catheter (endometriosis). Reproduced from Bukowska et al. (Citation2021) under Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).