Preparation and evaluation of a nanoemulsion containing cordycepin and its protective effect on skin

Abstract

The purpose of this work was to analyze and evaluate the functional properties of a new nanoemulsion that contained cordycepin. Droplet size and distribution were measured, and the stability of the nanoemulsion in different storage conditions was evaluated. We also tested skin irritation caused by the nanoemulsion, cordycepin stability in the nanoemulsion, anti-aging effect, and microbial challenge. The nanoemulsion was homogeneous with proper dispersion stability, and cordycepin was stable for eight months within the cosmetic nanoemulsion. The nanoemulsion did not irritate human hand and face skin, and the cosmetic nanoemulsion was effective in preventing microbial contamination of the product during use and storage. The new nanoemulsion containing cordycepin satisfied provisions of the 2015 Safety and Technical Standards for Cosmetics of the Ministry of Health, People’s Republic of China.

Graphical abstract

Keywords:

• nanoemulsion
• cordycepin
• functional properties
• microbial challenge test
• anti-aging

Acknowledgments

The authors thank AiMi Academic Services (www.aimieditor.com) for English language editing and review services.

Author contribution

Hucheng Zhang: Conceptualization, Supervision, Writing- Original draft preparation. Lina Deng: Writing- Reviewing and Editing. Jun Yang: Visualization, Investigation. Guowei Yang: Data curation. Haitao Fan: Software. Yiqi Yin: Methodology. Shuai Luo: Validation. Shuangshi Li: Resources. Linying Liu: Software. Ming Yang: Conceptualization, Supervision.

Disclosure statement

The authors report there are no competing interests to declare.

Data availability statements

Data available on request from the authors.

Additional information

Funding

This study was supported by Beijing Polytechnic project “Study on integration of genome, transcriptome and proteome of cordycepin producing strains” [grant number 2022 × 002-KXD] for Dr. Hucheng Zhang and General project of Beijing Municipal Education Commission “Study on microbial community structure and its influencing factors in MBBR wastewater treatment process” [grant number 2018Z004-003-KWY] for Dr. Jun Yang.