Figures & data
Table 1. Overview of gene therapy results in bone (re)generation.
Park
,
S. J.
and
Na
,
K.
2012
.
The transfection efficiency of photosensitizer-induced gene delivery to human MSCs and internalization rates of EGFP and Runx2 genes
.
Biomaterials
,
33
:
6485
–
6494
.
Reckhenrich
,
A. K.
,
Koch
,
C.
,
Egaña
,
J. T.
and
Plank
,
C.
2012
.
The use of non-viral gene vectors for bioactive poly-(D, L-lactide) implant surfaces in bone tissue engineering
.
European Cells and Materials
,
23
:
441
–
448
.
Wolff
,
J. A.
and
Rozema
,
D. B.
2008
.
Breaking the bonds: Non-viral vectors become chemically dynamic
.
Molecular Therapy
,
16
:
8
–
15
.
Ahn
,
H. H.
,
Lee
,
J. H.
,
Kim
,
K. S.
,
Lee
,
J. Y.
,
Kim
,
M. S.
,
Khang
,
G.
,
…
and
Lee
,
H. B.
2008
.
Polyethyleneimine-mediated gene delivery into human adipose derived stem cells
.
Biomaterials
,
29
:
2415
–
2422
.
He
,
X.
,
Dziak
,
R.
,
Mao
,
K.
,
Genco
,
R.
,
Swithart
,
M.
,
Li
,
C.
and
Yang
,
S.
2013
.
Integration of a novel injectable nano calcium sulfate/alginate scaffold and BMP2-gene modified MSCs for bone regeneration
.
Tissue Engineering Part A
,
19
:
508
–
518
.
Wegman, F., Geuze, R. E., van der Helm, Y. J., Öner, F. C., Dhert, W. J., & Alblas, J. (2012). Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model. Journal of Tissue Engineering and Regenerative Medicine. doi:10.1002/term.1571
Chew
,
S. A.
,
Kretlow
,
J. D.
,
Spicer
,
P. P.
,
Edwards
,
A. W.
,
Baggett
,
L. S.
,
Tabata
,
Y.
,
…
and
Mikos
,
A. G.
2011
.
Delivery of plasmid DNA encoding bone morphogenetic protein-2 with a biodegradable branched polycationic polymer in a critical-size rat cranial defect model
.
Tissue Engineering Part A
,
17
:
751
–
763
.
Park
,
J. S.
,
Na
,
K.
,
Woo
,
D. G.
,
Yang
,
H. N.
,
Kim
,
J. M.
,
Kim
,
J. H.
,
Chung
,
H. M.
and
Park
,
K. H.
2010
.
Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells
.
Biomaterials
,
31
:
124
–
132
.
Uchimura
,
E.
,
Yamada
,
S.
,
Uebersax
,
L.
,
Fujita
,
S.
,
Miyake
,
M.
and
Miyake
,
J.
2007
.
Method for reverse transfection using gold colloid as a nano-scaffold
.
Journal Bioscience and Bioengineering
,
103
:
101
–
103
.
Ferreira
,
E.
,
Potier
,
E.
,
Logeart-Avramoglou
,
D.
,
Salomskaite-Davalgiene
,
S.
,
Mir
,
L. M.
and
Petite
,
H.
2008
.
Optimization of a gene electrotransfer method for mesenchymal stem cell transfection
.
Gene Therapy
,
15
:
537
–
544
.
Kawai
,
M.
,
Maruyama
,
H.
,
Bessho
,
K.
,
Yamamoto
,
H.
,
Miyazaki
,
J.
and
Yamamoto
,
T.
2009
.
Simple strategy for bone regeneration with a BMP-2/7 gene expression cassette vector
.
Biochemical Biophysiology Research Community
,
390
:
1012
–
1017
.
Park
,
S.
,
Kim
,
Y. S.
,
Kim
,
W. B.
and
Jon
,
S.
2009
.
Carbon nanosyringe array as a platform for intracellular delivery
.
Nanotechnology Letters
,
9
:
1325
–
1329
.