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Aerosol Science and Technology Volume 57, 2023 - Issue 5
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Original Articles

Atmospheric aging increases the cytotoxicity of bare soot particles in BEAS-2B lung cells

Michal Pardoa Department of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, IsraelCorrespondence[email protected]
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Hendryk Czechb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0001-8377-4252View further author information
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Svenja Offerb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyView further author information
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Martin Sklorzb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyView further author information
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Sebastiano Di Bucchianicob Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0002-6396-892XView further author information
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Elena Hartnerb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0002-6798-2403View further author information
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Jana Pantzkeb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0001-5420-8905View further author information
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Evelyn Kuhnb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Andreas Pauld Group of Stable Isotopes in Aerosols, Troposphere (IEK-8), Institute of Energy and Climate Research, Forschungszentrum Jülich GmbH, Jülich, GermanyORCID Iconhttps://orcid.org/0000-0001-6327-4103View further author information
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Till Ziehmd Group of Stable Isotopes in Aerosols, Troposphere (IEK-8), Institute of Energy and Climate Research, Forschungszentrum Jülich GmbH, Jülich, GermanyORCID Iconhttps://orcid.org/0000-0001-5586-3709View further author information
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Zhi-Hui Zhange Department of Environmental Sciences, University of Basel, Basel, SwitzerlandView further author information
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Gert Jakobib Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Stefanie Bauerb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Anja Huberb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyORCID Iconhttps://orcid.org/0000-0002-4838-8951View further author information
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Elias J. Zimmermannb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0002-8766-180XView further author information
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Narges Rastakb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyView further author information
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Stephanie Binderb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Ramona Brejchab Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Eric Schneiderc Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0003-3090-6703View further author information
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Jürgen Orascheb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyORCID Iconhttps://orcid.org/0000-0002-1037-7544View further author information
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Christopher P. Rügerc Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyView further author information
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Thomas Grögerb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Sebastian Oederb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyView further author information
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Jürgen Schnelle-Kreisb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, GermanyORCID Iconhttps://orcid.org/0000-0003-4846-2303View further author information
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Thorsten Hohausd Group of Stable Isotopes in Aerosols, Troposphere (IEK-8), Institute of Energy and Climate Research, Forschungszentrum Jülich GmbH, Jülich, GermanyORCID Iconhttps://orcid.org/0000-0001-5722-6244View further author information
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Markus Kalberere Department of Environmental Sciences, University of Basel, Basel, SwitzerlandORCID Iconhttps://orcid.org/0000-0001-8885-6556View further author information
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Olli Sippulaf Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, FinlandORCID Iconhttps://orcid.org/0000-0002-6981-2694View further author information
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Astrid Kiendler-Scharrd Group of Stable Isotopes in Aerosols, Troposphere (IEK-8), Institute of Energy and Climate Research, Forschungszentrum Jülich GmbH, Jülich, GermanyORCID Iconhttps://orcid.org/0000-0003-3166-2253View further author information
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Ralf Zimmermannb Joint Mass Spectrometry Center (JMSC), Comprehensive Molecular Analytics (CMA), Department Environmental Health, Helmholtz Zentrum München GmbH, Neuherberg, Germany;c Joint Mass Spectrometry Center (JMSC), Department of Analytical and Technical Chemistry, Institute of Chemistry, University of Rostock, Rostock, GermanyORCID Iconhttps://orcid.org/0000-0002-6280-3218View further author information
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Yinon Rudicha Department of Earth and Planetary Sciences, Faculty of Chemistry, Weizmann Institute of Science, Rehovot, IsraelCorrespondence[email protected]
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Pages 367-383 | Received 06 Nov 2022, Accepted 31 Jan 2023, Published online: 17 Feb 2023

Figures & data

Table 1. Physical and chemical properties of undiluted (1:1) fresh- and aged-SP.

Figure 1. Cells viability after exposure to fresh soot particles (SP) and aged-SP.

Figure 1. Cells viability after exposure to fresh soot particles (SP) and aged-SP.

Figure 2. Principle component analysis (PCA) and differently expressed (DE) genes after exposure to fresh- and aged-SP.

Figure 2. Principle component analysis (PCA) and differently expressed (DE) genes after exposure to fresh- and aged-SP.

Figure 3. Oxidative stress response after exposure to fresh- and aged-SP.

Figure 3. Oxidative stress response after exposure to fresh- and aged-SP.

Figure 4. Inflammatory response after exposure to fresh- and aged-SP.

Figure 4. Inflammatory response after exposure to fresh- and aged-SP.

Figure 5. Expression of aryl hydrocarbon receptor (AhR)-related genes following exposure to fresh- and aged-SP.

Figure 5. Expression of aryl hydrocarbon receptor (AhR)-related genes following exposure to fresh- and aged-SP.

Figure 6. DNA damage and cell cycle indicators were measured following exposure to fresh- and aged-SP.

Figure 6. DNA damage and cell cycle indicators were measured following exposure to fresh- and aged-SP.

Figure 7. A schematic model for fresh- and aged-SP-induced cytotoxicity in lung cells.

Figure 7. A schematic model for fresh- and aged-SP-induced cytotoxicity in lung cells.
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