Nutritional status, especially body mass index, from birth to adulthood and lung function in young adulthood

Abstract

Objective: The study assessed the impact of body mass index (BMI) at birth, infancy, and adulthood, and waist circumference on lung function.

Methods: Using a longitudinal design 1221 Chilean young adults were studied. A standardized respiratory questionnaire was used. Forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC), height, weight and waist circumference were measured. Data at birth and at 1 year were obtained from clinical notes.

Results: Males with a BMI ≥ 30 and women with a BMI < 20 had a lower FEV₁ (−230 mL, 95% CI −363 to −98; −106 mL, 95% CI −211 to −0.18, respectively). In both sexes those with a BMI 20–25 had the highest FEV₁ and FVC. In males there was a negative association between waist circumference and FEV₁ and FVC while in women the middle tertile had the highest FEV₁ and FVC. There was an association between birthweight and BMI at birth, and FEV₁ in men, when unadjusted for other measurements.

Conclusions: BMI and waist circumference in adulthood make a greater impact on lung function in adulthood than anthropometric measurements at birth and infancy. Proxy measures of fatness in adulthood reduce lung function, but the pattern between fatness and lung function by sex may be different.

• Body mass index
• obesity
• lung function
• waist circumference
• birthweight