Development, In Vitro and In Vivo Evaluation of Hydrogel Based System of Carboxymethyl Arabinoxylan for Controlled Delivery of Rabeprazole Sodium

ABSTRACT

Present study deals with development of polymeric systems for rabeprazole sodium to accomplish a lingering therapeutic outcome. Carboxymethyl arabinoxylan exhibited variety of ideal characteristics for polymeric drug carrier. Free radical polymerization was successfully employed to prepare pH responsive polymeric network of carboxymethyl arabinoxylan with acrylic acid. FTIR, SEM, thermogravimetric analysis and X-ray diffraction verified the graft copolymerization. Graft copolymers revealed highly pH responsive swelling, consequently drug release at intestinal pH. In vivo evaluation indicated improvement in relative bioavailability by exhibiting increase in C_max of polymeric system and same oral dose of rabeprazole sodium were 103.71 ± 16.081 and 61.263 ± 5.37 ng/mL, respectively.

GRAPHICAL ABSTRACT

KEYWORDS:

• Bioavailability
• carboxymethylation
• graft copolymerization
• hydrogel
• In Vivo