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Women & Health Volume 63, 2023 - Issue 4
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Research Article

Inflammatory biomarkers and lipid metabolism parameters in women with mild cognitive impairment and dementia

Yana Zorkinaa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, Russia;b Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, RussiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0247-2717View further author information
, PhDORCID Icon,
Olga Abramovaa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, Russia;b Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0001-8793-1833View further author information
ORCID Icon,
Valeria Ushakovaa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, Russia;b Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0003-3480-910XView further author information
, PhDORCID Icon,
Denis Andreyuka Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-3349-5391View further author information
, PhDORCID Icon,
Nika Andriushchenkoc Department of Biology, Shenzhen MSU-BIT University, Shenzhen, Guangdong, ChinaORCID Iconhttps://orcid.org/0000-0001-6356-758XView further author information
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Konstantin Pavlovb Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0001-8390-7000View further author information
, PhDORCID Icon,
Victor Savilova Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-1425-1586View further author information
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Kristina Solovevaa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-2481-3693View further author information
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Marat Kurmisheva Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0001-7354-7216View further author information
, PhDORCID Icon,
Timur Syunyakova Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-4334-1601View further author information
, PhDORCID Icon,
Olga Karpenkoa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-0958-0596View further author information
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Alisa Andryushchenkoa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-7702-6343View further author information
, PhDORCID Icon,
Olga Gurinab Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0001-6942-5531View further author information
, PhDORCID Icon,
Georgiy Kostyuka Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-3073-6305View further author information
, PhDORCID Icon &
Anna Morozovaa Research Centre for Neuropsychiatry, Mental-Health Clinic No. 1 named after N.A. Alekseev, Moscow, Russia;b Department of Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, RussiaORCID Iconhttps://orcid.org/0000-0002-8681-5299View further author information
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Pages 285-295 | Received 23 Apr 2022, Accepted 20 Feb 2023, Published online: 07 Mar 2023
 
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ABSTRACT

The detection of specific markers of dementia and mild cognitive decline (MCI) could be the key to disease prevention and forehanded treatment. Female gender is one of the major risk factor for dementia. The aim of our study was to compare serum concentration of some factors related to lipid metabolism and the immune system in patients with MCI and dementia. The study was performed on women >65 years old: controls (n = 75), diagnosed with dementia (n = 73) and MCI (n = 142). Patients were evaluated using Mini-Mental State Examination, Clock Drawing Test and Montreal Cognitive Assessment scales in the period 2020–2021. The level of Apo A1 and HDL was significantly decreased in patients with dementia; the level of Apo A1 was also decreased in MCI. EGF, eotaxin-1, GRO-α, and IP-10 were elevated in patients with dementia compared to the controls. IL-8, MIP-1β, sCD40L, and TNF-α levels were decreased in MCI patients and increased in patients with dementia compared to the control. Serum VEGF levels were decreased in MCI and dementia patients in comparison with the control. We hypothesize that no single marker can indicate a neurodegenerative process. Future research should focus on identifying markers to determine possible diagnostic combinations that can reliably predict neurodegeneration.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

ZY, MA, KO designed the study. KM, SV, ST, AN, AD collected the samples and demographic data and contributed to study design. AO, UV, PK performed biological parameters measurements. ZY, AO, MA – writing the paper. ZY – statistical analysis, SK – paper editing. KG and AA – supervision, project administration, and funding acquisition.

Supplementary data

Supplemental data for this article can be accessed online at https://doi.org/10.1080/03630242.2023.2185750.

Additional information

Funding

The work was supported by the the Russian Foundation for Basic Research (RFBR) [20-04-60546].

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