Fusarium mycotoxins: a trans-disciplinary overview

Figures & data

Fig. 1. (Colour online) Illustration of the biosynthetic pathway leading to production of trichothecenes, with linkages shown to the corresponding gene cluster for three generically represented Fusarium species. (Chemotype, and corresponding genotype, differences can be found within species.) Labels at the arrows indicate the TRI gene whose product enacts the indicated biotransformation. DON = deoxynivalenol; 3-ADON = 3-acetyl-deoxynivalenol; 15-ADON = 15-acetyl-deoxynivalenol; NIV = nivalenol; NX-2 = NX-2 toxin; NX-3 = NX-3 toxin; T-2 = T-2 toxin. Coloured polygons indicate the presence and orientation of TRI genes within a genome. Gene lengths are not drawn to scale. Ψ indicates a pseudogenized gene. Gene symbols are colour-coded by functional category, as indicated in the legend. The inset figure depicts a generic trichothecene backbone structure, and indicates the conventional numbering of atom positions.