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Cancer Investigation Volume 26, 2008 - Issue 8
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ORIGINAL ARTICLECellular and Molecular Biology

Over-Expression of COX-2 Induces Human Ovarian Cancer Cells (CAOV-3) Viability, Migration and Proliferation in Association with PI3-k/Akt Activation

Pingqing Gu Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China
,
Yajuan Su Clinical Laboratory, Southern Medical University, Guangzhou, P.R. of China
,
Shuyu Guo Clinical Laboratory, Southern Medical University, Guangzhou, P.R. of China
,
Lichen Teng Clinical Laboratory, Southern Medical University, Guangzhou, P.R. of China
,
Ye Xu Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China
,
Juan Qi Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China
,
Hui Gong Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China
&
Youqun Cai Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China
 show all
Pages 822-829 | Published online: 11 Jun 2009
 
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Abstract

COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k/Akt in these processes. The results showed that COX-2 increased the cells viability, migration and augment the number of CAOV-3. LY294002 could reduce COX-2 induce cells viability, migration and proliferation. These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.

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