Abstract
Biochemical activities of Fluorescein, Rose Bengal and Rhodamine 101 were studied by DNA binding, antibacterial and cytotoxic studies. DNA binding studies were done using spectroscopic, thermodynamic and molecular modeling techniques. Antibacterial activities were investigated against a gram-negative bacteria Escherichia coli and a gram-positive bacteria Staphylococcus aureus. Cytotoxic activities were studied against Wi-38 cell line. We observed these dyes bound to minor groove of DNA and structural diversity of dyes affect the phenomenon. No significant antibacterial and cytotoxic activities of these dyes were found in our observations.
GRAPHICAL ABSTRACT
![](/cms/asset/eaa14f37-e8d3-49bc-81b7-5e6902f237cf/tbsd_a_1936180_uf0001_c.jpg)
Communicated by Ramaswamy H. Sarma
Disclosure statement
No potential conflict of interest was reported by the authors.
Acknowledgements
The authors would like to thank Prof. Subrata Mukhopadhyay, Department of Chemistry, Jadavpur University. The authors also thank Mr. Asif Hasan, department education (post graduating), ABS academy, Durgapur for his valuable help.