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Dermatology

Mediation roles of neutrophils and high-density lipoprotein (HDL) on the relationship between HLA-DQB1 and rosacea

Wenqin Xiaoa Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China;b Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;d Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South Univerisity, Changsha, ChinaView further author information

Ji Lia Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China;b Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;d Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South Univerisity, Changsha, ChinaCorrespondence[email protected]
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Xin Huange Department of Epidemiology and Biostatistics, School of Medicine, Hunan Normal University, Changsha, ChinaView further author information

Quan Zhuf Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaView further author information

Tangxiele Liua Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China;b Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;d Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South Univerisity, Changsha, ChinaView further author information

Hongfu Xiea Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China;b Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;d Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South Univerisity, Changsha, ChinaView further author information

Zhili Denga Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China;b Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;d Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South Univerisity, Changsha, ChinaView further author information

Yan Tanga Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China;b Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;c National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;d Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South Univerisity, Changsha, ChinaCorrespondence[email protected]
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Figures & data

Table 1. The demographic and clinical features of the rosacea cases and controls.

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Table 2. Association between HLA-DQB1 allele, genotype and rosacea *.

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Table 3. Association between HLA-DQB1 allele, genotype and rosacea severity.

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Figure 1. Mediation analysis for HLA-DQB1*03:03, neutrophils, HDL and rosacea risk or severity. HDL: high-density lipoprotein; IGA: disease severity of rosacea.

Table 4. Association between HLA-DQB1 gene, neutrophils, HDL, LDL, rosacea and rosacea severity (IGA).

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Table 5. Mediation of neutrophils and HDL, LDL on the relationship between HLA-DQB1 allele and rosacea or rosacea severity.

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Data availability statement

Data are contained within this article or its supplementary material.

Mediation roles of neutrophils and high-density lipoprotein (HDL) on the relationship between HLA-DQB1 and rosacea

Table 1. The demographic and clinical features of the rosacea cases and controls.

Table 2. Association between HLA-DQB1 allele, genotype and rosacea *.

Table 3. Association between HLA-DQB1 allele, genotype and rosacea severity.

Table 4. Association between HLA-DQB1 gene, neutrophils, HDL, LDL, rosacea and rosacea severity (IGA).

Table 5. Mediation of neutrophils and HDL, LDL on the relationship between HLA-DQB1 allele and rosacea or rosacea severity.

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Mediation roles of neutrophils and high-density lipoprotein (HDL) on the relationship between HLA-DQB1 and rosacea

Figures & data

Table 1. The demographic and clinical features of the rosacea cases and controls.

Table 2. Association between HLA-DQB1 allele, genotype and rosacea *.

Table 3. Association between HLA-DQB1 allele, genotype and rosacea severity.

Table 4. Association between HLA-DQB1 gene, neutrophils, HDL, LDL, rosacea and rosacea severity (IGA).

Table 5. Mediation of neutrophils and HDL, LDL on the relationship between HLA-DQB1 allele and rosacea or rosacea severity.

Supplemental Material

Data availability statement

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