Chemical constituents of Brazilian Propolis from the state of Bahia and their growth inhibitory activities against cancer cells

Figures & data

Figure 1. 2D-NMR correlations of compound 1 (bold line shows ¹H-¹H COSY correlation, solid arrows show HMBC correlations).

Figure 2. ORTEP drawing of the monohydrate of compound 1, as determined by X-ray crystal analysis.

Figure 3. Structures of compounds 1 - 6 isolated from the ethanol extract of BA Propolis.

Table 1. The growth-inhibitory activity of constituents isolated from the ethanol extract of BA propolis against human cancer cell lines.

Compounds	IC50 (μM)
	DLD-1	MCF-7	A549
Novel 2-phenoxychromone (1)	65.8	174.4	81.9
3-O-methylquercetin (2)	16.2	16.7	34.2
3,6,4′-trimethoxychrysin (3)	17.1	50.5	19.9
3,6-dimethoxyapigenin (4)	31.0	41.9	47.0
6-methoxykaempferol (5)	101.8	>200.0	125.1
6-methoxyapigenin (6)	>200.0	>200.0	>200.0
BA propolis extract (μg/mL)	13.8	16.8	21.7